Lei Wei

Associate Professor @ Roswell Park. Cancer genomics. Bioinformatics. Views are my own.

[Tao Liu (τν) @fooliu]

Also, MACS3 paper is out, updating our 18yrs old reference paper after years of maintenance and development. Many thanks to the community for the continuous contributions and to CZI @cziscience EOSS program for the support. https://t.co/Z6KYxF2mh2 2/2

[Tao Liu (τν) @fooliu]

MACS 3.1.0 is released with a jaw-dropping 40-60x improvement in speed, thanks to @jmschreiber91's auto-optimize work! AI achieved in one weekend what I've been hoping for years! Now peak calling that once took minutes can be completed in seconds! https://t.co/xv3YWIjUCd 1/2

[Lei Wei @lweiub]

https://t.co/Gy70ms7cOE

[Lei Wei @lweiub]

Glad to share our new JID study comparing 5-FU and PDT as field treatments for UV-damaged skin at the mutational level. Both reduced epidermal clonal mutations, but with distinct effects: 5-FU preferentially depleted small clones, while PDT acted more uniformly across clone sizes

[Lei Wei @lweiub]

95% of TNBCs have TP53 mutations https://t.co/dOIOwLMXMd

[Lei Wei @lweiub]

Photodynamic therapy reduces the burden of small ultraviolet-induced epidermal clones in human and mouse skin https://t.co/6qFXbjkAUU

[Lei Wei @lweiub]

@DrBinChen Congratulations!

[. @IreneGhobrial]

Great point. Treat higher risk MM like ALL

[Enrique Grande @drenriquegrande]

⚡️️ On @NatRevClinOncol - Harnessing big data to characterize immune-related adverse events.

#immunotherapy

https://t.co/vO5hMJTJcf

[Roel Verhaak @roelverhaak]

If this is true (and I have no reason to doubt it), this is a mindblowing discovery!

[Amherst Police NY 🚔 @amherstpoliceny]

[AMHERST POLICE, NY] -- A message from the Town of Amherst Emergency Services.

[zack chiang @z_chiang]

Just released @Nature: slide-DNA-seq, our new method for spatial DNA sequencing in tissues 🧬

Excited to add a genetic dimension to the rapidly expanding spatial toolbox with the tech dev superteam of Tongtong Zhao, @JD_Buenrostro & @insitubiology (1/6)

https://t.co/Au1Fe0tOpf

[Michael Hoffman @michaelhoffman.bsky.social @michaelhoffman]

R01 for Supporting Talented Early Career Researchers in Genomics from @genome_gov https://t.co/Xkt2CzA9ly

[Heng Li @lh3lh3]

Two tenure-track openings from our department at Harvard Medical School with computational genomics being one of the focuses.

[Itai Yanai @ItaiYanai]

The difference between doing a project and presenting it. An observation can lead to many avenues of explorations before focus turns to a specific discovery. Presenting it, in a talk / paper, follows inversely, with broad perspectives coming before & after the specific discovery.

[Olivier Elemento @ElementoLab]

Wow - cancer patients who took certain anti-histamine medications because of allergies responded better to immunotherapy. Turns out histamine binds to macrophage receptors, makes macrophages immunosuppressive, thus inducing T cell dysfunction https://t.co/x0dJJqhv3w

[Xiaole Shirley Liu @XShirleyLiu]

Our Chromap paper is published today, so people can use this instead of BWA for ChIP-seq, HiC, scATAC-seq alignment and pre-processing. This should be cited more than MACS!

[Roswell Park @RoswellPark]

(1/2) Thank you, @RepBrianHiggins, for your recognition of our friend, Kevin Hays. Diagnosed with Colon Cancer at 28, Kevin used his story to spread awareness to others about the risk of colorectal cancer in young adults and the importance of regular screening.

[Bartomeu Colom @Bartomeu_Colom]

Out today @Nature! Human tissues accumulate cancer-driver mutations with age, yet tumor formation remains rare, why!? We show that mutant clones in the normal epithelium can have a tumor-protective role by outcompeting and eliminating nascent tumors. https://t.co/GfBaLNHvBq

[Jason Sheltzer @JSheltzer]

David Julius is an academic 4th-generation Nobel Laureate:

Julius (2021 Nobel) did his PhD under Randy Schekman (2013 Nobel) who did his PhD under Arthur Kornberg (1959 Nobel) who was trained by Carl and Gerty Cori (1947 Nobel) as well as Severo Ochoa (1959 Nobel).