Patrick Lyden

Professor and Clinician, Physiology & Neuroscience, Neurology, Keck School of Medicine of USC, #stroke #ischemia #thrombolytics (account managed by lab members)

[Mozammel Bhuiyan @AdibMozammel]

I had the opportunity to give an oral abstract presentation on our work investigating the role of endothelial protease activated receptor 1 (PAR1) in promoting BBB breakdown after ischemic stroke in #ISC26 in New Orleans last week. Here is the link: https://t.co/7yLY5rDaBN

[Mozammel Bhuiyan @AdibMozammel]

Here is the link to the paper: https://t.co/2wNun1oJOK

[Mozammel Bhuiyan @AdibMozammel]

Our results indicate that this model still needs further optimization to get reproducible stroke. The results paper from our feasibility study is out in ‘Translation Stroke Research’ journal now. Thanks and congratulations to all coauthors from the Lyden lab and SPAN network.

[Mozammel Bhuiyan @AdibMozammel]

To increase translational relevance, we tried to standardize rat thromboembolic stroke model to assess the feasibility for using this model in the Stroke Preclinical Assessment Network (SPAN).

[Mozammel Bhuiyan @AdibMozammel]

While thromboembolic stroke model matches more closely with the inflammatory cascades of human ischemic stroke than our popular nylon filament model, it is hard to get reproducible stroke with less mortality in this model.

[Mozammel Bhuiyan @AdibMozammel]

I am happy to share that our method paper on optimizing and standardizing the thromboembolic model of stroke in rats for the Stroke Preclinical Assessment Network (SPAN) is online now. Thanks to all colleagues from SPAN and Lyden Lab. Here is the link:

https://t.co/Ar8ISnP5E6

[Mozammel Bhuiyan @AdibMozammel]

Excited to share the preprint of a manuscript from my PhD work. We showed that delivery of chitosan-based hydrogel into the infarct cavity reduces reactive astrogliosis and promotes the proliferation of neural progenitor cells after stroke. https://t.co/AqGWdCDd6y

[AHA Science @AHAScience]

From panels to keynotes to posters, the International Stroke Conference is the place to learn from the best and brightest from around the globe. Be part of the conversation at #ISC26 in New Orleans.

ISC26 Chairs: @LaurenHSansing @bijoymenon

📷 #ISC25

[Stroke AHA/ASA @StrokeAHA_ASA]

#STROKE: Fingolimod treatment shows mixed effects on post-ischemic stroke outcomes depending on comorbidities in a randomized, multicenter rodent preclinical trial (SPAN). @sheth_kevin @LD_McCullough @LaurenHSansing #AHAJournals https://t.co/yyD6QFtbKZ

[Patrick Lyden @lydenlab]

Another paper from our SPAN 1.0 studies is out in @StrokeAHA_ASA. Fasudil, a Rho-kinase (ROCK) inhibitor, improved the primary outcome (day 28 corner test) in mice. Thanks to the lead author @imai_takahiko and the Ayata Lab. Here is the link. https://t.co/bPvSBDAJW2

[Takahiko Imai, Ph.D. @imai_takahiko]

I met Prof. Lyden @lydenlab in BRAIN & BRAIN PET @BRAINPET25

[LaurenHSansing @LaurenHSansing]

Calling all stroke researchers and clinicians!! Deadline for invited symposia suggestions for #ISC26 in New Orleans is Thursday, April 3, 2025 at 6:00 a.m. ET! New categories!! Get your ideas into the conference :) @AHAScience @bijoymenon @ShadiYaghi2 @Braindoc_MGH

[Bijoy K Menon @bijoymenon]

Last date for ISC session submissions is tomorrow!!! This is your chance to shape ISC2026! @StrokeAHA_ASA @LaurenHSansing @NguyenThanhMD @ChaturvediNeuro @AHAScience

[AHA Science @AHAScience]

We want your ideas! We invite you to submit your exciting and novel session ideas for debate topics, session topics and speakers for #ISC26. This is your opportunity to have your suggestions considered for the next International Stroke Conference!

https://t.co/1onWvuIStX

[NIH @NIH]

News: NIH-funded study identifies potential new stroke treatment https://t.co/jzeHWnCLGa

[Stroke AHA/ASA @StrokeAHA_ASA]

#STROKE: Uric acid supplementation provides cerebroprotection across different animal species, sex, age, and comorbidities. #AHAJournals @ChauhanLab @Nirav_Dhanesha https://t.co/E0vnsNZQlQ

[Prof Peter Hotez MD PhD DSc(hon) @PeterHotez]

So when you try to slash the budgets of our research universities, our academic health centers, our sources of innovation, which ensure the greatness, the biosecurity, of the United States, that’s the head scratcher. Please reconsider, try to be more thoughtful, think deeper

[Prof Peter Hotez MD PhD DSc(hon) @PeterHotez]

Honestly I think any American who cares about our future supports DOGE, Elon, that’s not the problem. It’s your failure to understand our nation is built on the strength of our great research universities institutions, which you benefited more than anyone I know, that’s the issue

[American Heart News @HeartNews]

#ISC25 may be a wrap but you can catch up on all of the highlights from the meeting Chair and Vice Chair. https://t.co/DfrQ3pO6yB

[Patrick Lyden @lydenlab]

Andreia Morais is presenting the “MRI outcomes in the SPAN trial” now at #ISC2025