Hannah Macpherson

Long Read Genetics and Transcriptomics, University College London. All tweets are of my own making ✨ she/her

[The Nobel Prize @NobelPrize]

The 2024 #NobelPrize in Physiology or Medicine focuses on the discovery of a vital regulatory mechanism used in cells to control gene activity. Genetic information flows from DNA to messenger RNA (mRNA), via a process called transcription, and then on to the cellular machinery for protein production. There, mRNAs are translated so that proteins are made according to the genetic instructions stored in DNA. Since the mid-20th century, several of the most fundamental scientific discoveries have explained how these processes work.

In 1993, this year's Nobel Prize laureates published unexpected findings describing a new level of gene regulation, which turned out to be highly significant and conserved throughout evolution. They discovered microRNA, a new class of tiny RNA molecules that play a crucial role in gene regulation.

Read more: https://t.co/8RwUplwYQA

[Dervis Salih @DervisSalih1]

@em_ka_gu @Stella_Tasou @Macpherson_HL @RDUnwin @juanBotiaBlaya @CharlesColdroom @WellsSara @UCLIoN @UKDRI @MRCHarwell @MRCMouseNetwork Preprint is here: Long-read transcriptomic identification of synaptic adaptation to amyloid pathology in the App(NL-G-F) knock-in mouse model of the earliest phase of Alzheimer’s disease
https://t.co/JEigaucwji

[UCL Long Read Sequencing Service @LRS_UCL]

We’re hiring for a Senior Research Technician! Come join us to work with @nanopore and @PacBio technologies
https://t.co/llvglDz6AL

[William Scotton @drwillscotton]

**NEW PAPER ALERT** Delighted for the first work from the Pick’s disease International Consortium (PIC) to be published in Lancet Neurology.. (1/12) https://t.co/LrjcjNGPu8

[My Neuropath News @NeuropathClinic]

Letter to the editor on: Hornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusions by Park et al. (2022) #neuropath
https://t.co/LPTyyL9oMq

[Hannah Macpherson @Macpherson_HL]

An exciting project to be part of and a great use case of @nanopore adaptive sampling for elusive genetic diagnoses.

[Hannah Macpherson @Macpherson_HL]

Had a great time discussing the future of long read transcriptomics and hearing from some amazing researchers!

[UCL Queen Square Institute of Neurology @UCLIoN]

Read all about the wide-ranging and insightful UCL-PacBio RNA Symposium 2023, highlighting the latest advancements in RNA sequencing: https://t.co/DFZcYw8TKm @ionsynapse @em_ka_gu @Macpherson_HL @anaconesa @celarber @PacBio @MinaRyten

[Hannah Macpherson @Macpherson_HL]

Very excited about this!

[UCL Long Read Sequencing Service @LRS_UCL]

We're hosting a Long Read Transcriptomics @PacBio day on November 21st! Great talks mostly focused on neurodegenerative disease or wider analysis tools. Sign up here: https://t.co/s8KUI07Sg5

[Hannah Macpherson @Macpherson_HL]

@drwillscotton Amazing!!

[William Scotton @drwillscotton]

Creating the Picks disease International Consortium: Association study of MAPT H2 haplotype with risk of Picks disease .. 1/5 https://t.co/AClN2LIp66

[Hannah Macpherson @Macpherson_HL]

@drwillscotton Too kind!

[Maryam Shoai @MaryamShoai]

Interested in #neurodegenerativediseases and #Bioinformatics? Join John Hardy’s team at Queen Square Institute of Neurology to learn more about Genetics and predictive modelling.
Closing date: 12th of April

https://t.co/AI12ITySRU…

#UCL

[Hannah Macpherson @Macpherson_HL]

@martinalexsmith Gutted! How funny

[Hannah Macpherson @Macpherson_HL]

But has anyone tried to align it 👀

[Martin Smith @martinalexsmith]

How to save on sequencing costs #chatgpt4

[Hannah Macpherson @Macpherson_HL]

Very proud to have done some long read sequencing with @nanopore tech for this study with @LRS_UCL

[UCL News @uclnews]

“Our data now strongly point to AAV2 as the cause of this unknown hepatitis": Researchers at @UCLchildhealth & @GreatOrmondSt led by Prof @judith_breuer have found a link between the common virus AAV2 & unexplained cases of hepatitis cases in children https://t.co/bIQvB3CMd7

[Hannah Macpherson @Macpherson_HL]

We're advertising for a Research Assistant role in the Ryten lab at UCL to work on Long Read Sequencing (PacBio and Nanopore). Feel to free to DM with any questions :) https://t.co/f1NI7TpWGu

[Hannah Macpherson @Macpherson_HL]

Didn’t know Wiley did this, nice email to receive even if I’m roughly the 8th author 🤓

[Hannah Macpherson @Macpherson_HL]

Huge range of projects - from neurodegeneration to de novo genomes for ecological research. Long Read was the Nature Method of the year 2022, so a great time to get involved. Feel free to DM me if you have any questions

[UCL Long Read Sequencing Service @LRS_UCL]

We’re hiring for a Senior Research Technician! The ad is broad but the plan is for the role to be entirely Long Read Sequencing with us - using both @nanopore and @PacBio technologies https://t.co/josxZ2D8HX