Maddie Mix

@Iowa_MSTP MD-PhD candidate | Studying brain-resident memory T cells | She/her 🩺🔬

[Maddie Mix @madmixmed]

Delighted to share our recently published work in @NatImmunol. We show here that normalized microbial exposures in mice enhance memory T cell surveillance of the brain and modify seizure outcomes. https://t.co/w2GbgUalNh

[Wassim Elyaman @WassimElyaman]

TCB2027 is coming!
📍 January 14-15, 2027
Join us for two days of exciting discoveries in T cells, brain immunity, and neurodegenerative disease. Speaker lineup and registration coming soon! #TCB2027 #Neuroimmunology #BrainImmunity

[Waggoner Lab @LabWaggoner]

Review @PCRosato1
Living rent free in your head: resident memory T cells
https://t.co/zASYFu4fiH

[Waggoner Lab @LabWaggoner]

Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy @jclinicalinvest @HartyLab
https://t.co/TlfmuTSIpa

[University of Iowa Pathology @UIPathology]

A lipid nanoparticle-encapsulated mRNA vaccine encoding a string of Plasmodium CD8+T cell epitopes was designed and found that a combined RAS-plus-mRNA vaccine regimen enhances liver-resident memory T cells and protection in murine malaria-experienced hosts.

[Nature Microbiology @NatureMicrobiol]

Out Now! mRNA vaccination overcomes haemozoin-mediated impairment of whole-parasite malaria vaccines in mice https://t.co/jRPImjTg2t

[bioRxiv Microbiology @biorxiv_micrbio]

mRNA vaccination overcomes hemozoin-mediated impairment of whole parasite vaccine efficacy for malaria https://t.co/TzM35xmJUB #biorxiv_micrbio

[Lola Lozano @lola_p_lozano]

Happy to share our new study in @urogoldjournal and freely available at link below for 50 days! Thank you to incredible team @UIowa_urology , couldn’t achieve these dreams without you all!

https://t.co/8u1xu82qsX

[University of Iowa Pathology @UIPathology]

Congratulations to Dr. Mariah Hassert for receiving a K99/00 Pathway to Independence Award from the National Institute of Allergy and Infectious Diseases! Dr. Hassert received this award for her proposal "Hemozoin and liver stage malaria vaccine efficacy."

[Journal of Physiology @JPhysiol]

🎓 EDITOR'S CHOICE 🎓

Kreitlow et al. housed a mouse model of #epileptic encephalopathy in constant darkness. Fatal seizures still occurred at night, implying intrinsic #circadian control. The findings have implications for the prevention of SUDEP.

📜 https://t.co/w1D7Az5NfA

[Journal of Physiology @JPhysiol]

Benjamin L. Kreitlow (@IowaNeurology @UIowaNeuro) et al. observed that seizure-related death exhibits a #circadianrhythm independent of seizure timing or sleep in a mouse model of Dravet syndrome 📉 📈

📜 Read the #Research here: https://t.co/w1D7Az5NfA

[Lexi Johnson @Johnson_AlexisM]

Excited to highlight this intriguing study from @Mix_Maddie and the @HartyLab showing how microbe exposure can durably reshape the brain’s immune landscape by driving T cell residency. Opens up fascinating questions around immune memory, neuroinflammation, and seizures! 🧠🔥

[Maddie Mix @madmixmed]

Many thanks to @Johnson_AlexisM and @JohnLukens for crafting an amazing summary of our recent work! Check it out here 🧠🦠⚡️

[John Lukens @LukensJohnR]

Peripheral infection wires T cells in the brain
https://t.co/ofvgSJ0bIX

[Maddie Mix @madmixmed]

@Cori_Fain Thanks for sharing Cori!! ☺️

[Duke Neurosurgery @Dukeneurosurg]

Continuing our countdown to #InternationalWomensDay ! 3 questions. 3 answers. 1 inspiring Duke brain tumor researcher: Here's Kathy Ayasoufi, PhD (@KAyasoufi). 💡🧠✨ #WomenInNeurosurgery #iwd #brainpower #braintumor

[Maddie Mix @madmixmed]

Congrats to my long-time colleague and friend @Cori_Fain for her recent #HannaGrayFellows award. Can’t wait to see all the future neuroimmunology she has in store for us! 🧠🔬✨

[Nate Mullin @nadmullin]

Don't judge a book by its cover!? 📖 Happy to share our study of nonsynonymous variants that turn out to work by disrupting normal splicing in the retina. It appears that the NR2E3 R311Q variant causes enhanced s-cone syndrome through this mechanism!

[John Lukens @LukensJohnR]

Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline
https://t.co/CIN7jPCBuI

[Waggoner Lab @LabWaggoner]

Unique surveillance properties of CD103+ TRM cells in the lungs of influenza-experienced mice, where lung TRM cells cluster at infection sites and promote myeloid cell influx upon antigen re-encounter @ImmunityCP @HartyLab @StephanieD22268
https://t.co/kphpMetmzJ

[Immunity @ImmunityCP]

Online now: Dynamic landscapes and protective immunity coordinated by influenza-specific lung-resident memory CD8+ T cells revealed by intravital imaging https://t.co/FlRjskBM8b