malhar

cto @origin_bio, @ycombinator, prev: uiuc cs @siebelschool

[malhar @malhar317]

Cell and gene therapies have the potential to offer a much higher quality of life to patients. Getting transcriptional control right is going to unlock a whole new class of them.

Happy to share a small preview into Axis’ ability to design novel regulatory DNA sequences. It’s so obvious that evolution has only explored a drop in the whole ocean. Now finally with AI can we start to take a deep dive.

[Y Combinator @ycombinator]

Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer.

Their model designs DNA switches & dials to program precise gene expression patterns in disease cells.

Congrats on the launch @YashRathod_75 and @malhar317!

https://t.co/yEHyoafehC

[Garry Tan @garrytan]

AI x Bio teams like Origin have coding agents, scaling laws, and a wave of big biotech deals all at their backs. This is barely touched territory. Crazy what this small team can do now.

[Yash Rathod @YashRathod_75]

Today, we're excited to release 10,000 fully AI-designed enhancer sequences for the research community. Axis was prompted to design sequences with targeted activity in one of three widely used cell-lines.

AI allows us to explore a vast design space, going beyond the natural genome.

[Y Combinator @ycombinator]

Burt (@trainburt) is building AI teammates for logistics. Teammates that can handle the manual, repetitive work that freight brokers and forwarders deal with every day.

Congrats on the launch, @bobbyzhong333 & @zerodaykurt!

https://t.co/AepYIDebcq

[Viraj Doshi @viraj9451]

Muon can accelerate LLM training, but does that benefit transfer to regulatory DNA sequence modeling with its different data distribution? 🧬

Our results show that Muon with independent weight decay (MuonW) hits our validation perplexity target in ~37% fewer FLOPs than the best Adam configuration.

[malhar @malhar317]

It was an honor to meet PM @narendramodi and discuss the potential impact of the work we are doing at @origin_bio

[Narendra Modi @narendramodi]

Interacted with CEOs of AI and deeptech StartUps at Seva Teerth. They are doing commendable work across sectors such as healthcare, agriculture, space, social enterprise and more. We discussed how to leverage the potential of AI in furthering the welfare of humanity.

https://t.co/rdA8V2KQGD

[Y Combinator @ycombinator]

.@PirisLabs delivers low-latency, low-cost AI inference by eliminating the memory wall using full-stack optical interconnects and a purpose-built software stack.

Congrats on the launch Ali & Keyvan!

https://t.co/sTMlCA2pcH

[Shaurya Mehta @ShauryaMehta14]

Check out the second episode of The Token Economy podcast with @malhar317 from @origin_bio

[Y Combinator @ycombinator]

.@dittobio discovers drugs for autoimmune diseases by harnessing parasite biology.

Viruses, ticks, and worms have experimented over millions of years to create proteins that control the human immune system.

Ditto Bio is using AI to identify these natural, drug-like proteins and engineer them into next-generation autoimmune therapies.

Congrats on the launch @AdairLBorges, @Mezarque, and @emilycpierce!

https://t.co/AvntC79k63

[Y Combinator @ycombinator]

.@autumn_ai_inc is building the first real-time signal intelligence platform for GTM teams.

Define your ICP and the signals that matter, and Autumn delivers a condensed, real-time feed filtered by intents.

Congrats on the launch @VishnuSampathk1 and @shiv_kampani!

https://t.co/Hrf6pQnzLB

[malhar @malhar317]

@caseykcaruso Thanks Casey :)

[malhar @malhar317]

@ShauryaMehta14 🫡

[malhar @malhar317]

@agupta Thanks Ankit! It’s awesome learning from you :)

[Ankit Gupta @agupta]

This is a very special team. True pair of polymaths at the intersection of computer science and biology. Their first model beat Deepmind's AlphaGenome on benchmarks and they're now using that to design cell and gene therapies. Congrats on the launch!

[malhar @malhar317]

@hunterharloff Thanks for all the support Hunter :)

[Hunter @hunterharloff]

Transformers extending to bio is one of those things that just feels obvious - what is the molecular machinery of life, if not a language?

Yash & Malhar are the real deal. Wicked sharp. Excited to support them as they shred legacy approaches.

[Yash Rathod @YashRathod_75]

We're still in the early days of durable and long lasting drugs based on transcriptional control - similar to where mRNA medicines were many years ago!

With AI designed regulatory DNA and millions of sequences we're lab testing, we aim to precisely program gene expression @origin_bio

[Y Combinator @ycombinator]

Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer.

Their model designs DNA switches & dials to program precise gene expression patterns in disease cells.

Congrats on the launch @YashRathod_75 and @malhar317!

https://t.co/yEHyoafehC

[malhar @malhar317]

@sandroherbig @merge Congrats Sandro!

[Liam Bai @liambai21]

Keytruda is one of the most important cancer drugs in history, saving countless lives and generating $30B per year in sales.

But how does it work? I break down the molecular mechanisms in this blog post, with interactive visualizations 👇