Malte Gersch

Chemical Biologist & Research Groupleader at Max Planck & TU Dortmund. Interested in proteases, ubiquitin, the outdoors and more.

[Malte Gersch @MalteGersch]

Interested in Ubiquitin, Parkinson’s disease therapy, mitochondria or DUB inhibitors? This preprint may be for you:
We show how the deubiquitinase USP30 can specifically be inhibited & introduce a framework for DUB ligandability.

https://t.co/hD9nkeMrYj

Thread👇 – with movie!!

[Alexander Schubert @alexschbrt]

We started collecting applications for SciFounder Fellowship!!

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Deadline is 2/28 - 11:59 pm PST

[Malte Gersch @MalteGersch]

@Amelie_HJ @TU_Dortmund @uniallianz Welcome, @Amelie_HJ, it‘s fantastic to have you here!

[Malte Gersch @MalteGersch]

@werner_achim @nchembio Thanks, Achim!

[Malte Gersch @MalteGersch]

Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology @nchembio. Congratulations Kim, Kai, and all authors! https://t.co/YTV5td5koG

[Malte Gersch @MalteGersch]

For all ubiquitin, deubiquitinase and chemical biology aficionados:
Here's a preprint from the lab introducing 2 new active DUBs in humans & a unique type of DUB activity one would miss with the widely used panels of free ubiquitin chains.
https://t.co/ji1Z8jBNSg
Thread👇(1/10)

[Malte Gersch @MalteGersch]

@rbdamgaard Thank you, Rune!

[Rapé Lab @RapeLab]

Excited to report our discovery of an important component of the oxidative stress response, the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress.

https://t.co/7wEkn6nznp

[Malte Gersch @MalteGersch]

@DuccioConti @nchembio Thanks, Duccio!

[Malte Gersch @MalteGersch]

@Schroeterfisch Thank you, Christian!

[Malte Gersch @MalteGersch]

Let‘s (re)connect at 🦋 if you like: https://t.co/eh5rFxxT0u

[Tycho Mevissen @TychoMevissen]

Excited that our work on transcription-coupled DNA repair is now published @CellCellPress! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples stalled Pol II to TFIIH. 🧬🐸

➡️ https://t.co/0SDr81nzhu

[Rune Busk Damgaard @rbdamgaard]

Excited to share this work led by @CamillaElb
where we identify an entirely new role of LUBAC as a critical regulator of AMPK, the energetic stress response, and cellular metabolism. If you are interested in #ubiquitin and #metabolism, have a read: https://t.co/9pOwjckaVP

[Sonja Lorenz @SLorenzLab]

Thanks very much, @MalteGersch, for inviting me to the @mpimoph. I had a great time in Dortmund!

[Malte Gersch @MalteGersch]

@SLorenzLab @mpimoph Thank you @SLorenzLab for your visit and exciting seminar!

[Malte Gersch @MalteGersch]

@UZH_Chemistry @Hartrampf_Lab Congrats Nina, this is fantastic! 🥳

[Rune Busk Damgaard @rbdamgaard]

Enjoying the #EMBOubiquitin2024 meeting in beautiful, sunny Cavtat with this lot @jnpruneda @Elliott_Lab_Ox @MalteGersch @YKulathu

[Winklhofer Lab @winklhofer_lab]

Applications are welcome, please share 📢

[Malte Gersch @MalteGersch]

@DuccioConti Thanks Duccio!

[Malte Gersch @MalteGersch]

Interested in Ubiquitin, Parkinson’s disease therapy, mitochondria or DUB inhibitors? This preprint may be for you:
We show how the deubiquitinase USP30 can specifically be inhibited & introduce a framework for DUB ligandability.

https://t.co/hD9nkeMrYj

Thread👇 – with movie!!

[Malte Gersch @MalteGersch]

@alessiociulli @NikolasKlink @gallant_kai @mpimoph @TU_Dortmund @IMPRS_LM @crc1430 Thanks Alessio, much appreciated!

[Malte Gersch @MalteGersch]

@LeoKiss5 Thanks Leo!

[Malte Gersch @MalteGersch]

The study also establishes chimeric protein engineering to aid DUB crystallization – maybe a crystallization rescue strategy for other challenging enzymes, too?
We are excited to share this work & hope you will enjoy reading the preprint.
We look forward to comments!

[Malte Gersch @MalteGersch]

This study is the result of persistent work and heroic efforts by Nafizul Kazi (on the far left in the picture). Chemistry by @NikolasKlink, cellular assays by @gallant_kai and Gian. Thank you for support by @mpimoph, @TU_Dortmund, @IMPRS_LM, @crc1430 .