Marco Manazza

MD, @MyUnisr graduate | Anesthesiology and ICU resident at @sanraffaeleMI @SRAnesthesiaICU

[Filippo D'Amico @DrFDamico]

🧩 Key message
Many strategies may reduce postoperative delirium, but none currently offer high-certainty evidence.

https://t.co/uxU0p9BMzX

[Filippo D'Amico @DrFDamico]

📚 What we did
We reviewed all RCT-based meta-analyses on pharmacological and non-pharmacological interventions to prevent postoperative neurocognitive disorders.

The result: the most complete evidence map so far.

https://t.co/uxU0p9BeKp

[Filippo D'Amico @DrFDamico]

💥The most comprehensive evidence on postoperative delirium has just been published.

Our umbrella review includes 114 meta-analyses and over 250,000 patients.
Here’s what we found. 👇

https://t.co/uxU0p9BeKp

[Tuhin 🇮🇳  @DrTuhinM]

🚀 It’s Out!🎉

📝Our correspondence on postoperative neurocognitive outcomes is now published in @Anaes_Journal

This piece reflects on the ambitious umbrella review by
@DrFDamico @Stefano__Turi @GiacomoMonti @azangrillo @giovannilandoni @manazzamarcoMD @Giulianalo_ and team
— a remarkable effort bringing 114 Meta-analyses under one roof. 👏🫡

🔗 Our Published Letter:
https://t.co/TSsKhLyBsm

🔗 Umbrella Review We Responded To:
https://t.co/guSCW3so7x

🙏 Sincere thanks to the reviewers and editorial team at @Anaes_Journal for constructive feedback, and to my co-author @loinabhi for the collaborative insights that shaped this work. Grateful for respectful academic dialogue and continued progress. 🙏

#Anaesthesia #Neurocognition #Delirium #POCD #PerioperativeCare #EvidenceBasedMedicine #PatientSafety #AcademicMedicine #UmbrellaReview

[ISICEM @ISICEM]

𝐒𝐞𝐫𝐢𝐨𝐮𝐬 𝐬𝐜𝐢𝐞𝐧𝐜𝐞. 𝐔𝐧𝐞𝐱𝐩𝐞𝐜𝐭𝐞𝐝 𝐟𝐨𝐫𝐦𝐚𝐭.
The @ISICEM Critical Care Input — presented this time in a new way. Watch it now and enjoy.
Credits @DrFDamico
#ISICEMelearning @NEJM
Full article https://t.co/rOeUBP3bQE

[Rosario Losiggio, MD @LosiggioRosario]

Huge participation this morning at our Journal Club @SRAnesthesiaICU , focused on organ donation after 10 years of the eCPR program for refractory cardiac arrest.
👏 Thanks to @MarinaPieri5 and @MABonizzoni for the outstanding presentation and discussion!

[Alessandro Belletti @alebelletti1]

Could pirfenidone prevent pulmonary fibrosis in #ARDS patients?

Our multicenter #PIONEER RCT will answer this question!

Full methodological manuscript now available at https://t.co/I4nqKJdoFG

@SRAnesthesiaICU @GiacomoMonti @giovannilandoni @marzarolimd @manazzamarcoMD

[Giovanni Landoni, MD @giovannilandoni]

#CCRdownunder24 congress just started

1st study ADAPT-Sepsis published in @JAMA_current

Procalcitonin guided protocol ⬇️ antibiotic treatment duration by 1day (significant)

but 28-day mortality non-sign⬆️by 7% (relative risk): from 19.4 to 20.9%

https://t.co/rK5vR6EP9X

[Rosario Losiggio, MD @LosiggioRosario]

6. Review - Curr Opin

This review highlights that the effectiveness of IV AA in the setting of AKI is supported by several mechanisms of action, including the improvement of renal #perfusion and oxygenation, and the recruitment of #RFR

🔗https://t.co/KcysMOIzKe

7/7

[Area Critica @Area_Critica_]

Cosa prevede la prima giornata di #Areacritica24?

✅Dettagli delle sessioni plenarie e parallele
✅Orari delle presentazioni e dei workshop

Iscriviti adesso 👉
https://t.co/7PsnecCZi6

#FOAMed

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

Oggi pomeriggio il secondo seminario congiunto delle Scuole di Anestesia e Rianimazione di Torino, Bicocca e San Raffaele:

📅 Oggi ore 16:00
📣 Early Goal Directed Communication Strategies in the ICU - Prof. Mistraletti

Partecipa qui: https://t.co/OBej11OP0X (Italian-only)

[Martina Baiardo Redaelli @BaiardoMartina]

💊Steroids are widely prescribed, but how to deal when therapy is no longer needed?

<3–4 weeks ➡️ no need for tapering, regardless of dose

>3–4 weeks ➡️ tapering

Have a look at this wonderful GL (tables, dosages and much more) @ESEndocrinology

🔗 https://t.co/44EbjxBxHe

[Martina Baiardo Redaelli @BaiardoMartina]

🧐 Did you ever used Angiotensin II in shock?

💉Either your answer is yes or no, here you can find the expert consensus statements for it!

➡️which patients
➡️advantages of ATII
➡️barriers & gaps in evidence

🔗 https://t.co/8qby8dr5ZN

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

ONLINE OPEN DAY | Scuola di Specializzazione di Anestesia, Rianimazione, Terapia Intensiva e del Dolore @MyUniSR

📆 Martedì, 10 settembre 2024 | 18:00
📍 Online | MS Teams: https://t.co/DBYO3tdrJA

Scegli Anestesia e Rianimazione. Scegli Università Vita-Salute San Raffaele.

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

Scegli Anestesia e Rianimazione. Scegli Università Vita-Salute San Raffaele.

Formazione avanzata, attenzione all’evoluzione delle conoscenze in ambito clinico e scientifico, internazionalizzazione e innovazione sono i punti di forza della nostra Scuola.

https://t.co/ghcjeGNtJE

[Filippo D'Amico @DrFDamico]

Randomized studies consistently show that intraoperative hypotension is not the cause of adverse events.

Continuing RASIs increases episodes and duration of hypotension but has no impact on mortality or adverse events (1.02 [0.87-1.19])

@giovannilandoni @KhannaAshishCCM @MichardFrederic @germ_red

[Martina Baiardo Redaelli @BaiardoMartina]

🦠 #WHO warns against a hypervirulent strain of Klebsiella pneumoniae

“unlike classic KP, hvKp infects healthy people, often with serious or fatal results”

⤵️You can read more @JAMA_current and @WHO

🔗 https://t.co/IjzkiEsNMR

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

Our #PROTECTIONtrial, which demonstrated that amino acids infusion reduces the occurrence of AKI in adults undergoing cardiac surgery, has been published in today’s issue of @NEJM.

Article: https://t.co/eiyf2hq22u
Editorial: https://t.co/07kuT7lNZp
Video: https://t.co/Tdayyoud5u

[Tommaso Scquizzato, MD @tscquizzato]

The #PixelWatch3, recently launched by @Google, introduces an #AI loss of pulse detection feature, providing automated #CardiacArrest detection for the first time.

Early recognition of cardiac arrest and calling for help are the first and most critical actions, yet they are frequently delayed.

Nearly half of cardiac arrests outside the hospital are unwitnessed—a deadly situation.

While many smartwatches have fall detection features, no devices have been capable of detecting the absence of a pulse (a cardiac arrest) before.

Google's new loss of pulse detection technology continuously monitors pulse and motion, triggering an alert and calling emergency services if no pulse, movements or response are detected.

The sensitivity and specificity of this feature remain unknown. In the past, smartwatches with fall detection features have caused unnecessary calls, diverting emergency resources needed elsewhere, a critical aspect that deserve attention from developers and users.

This is the first concrete step toward improving early recognition and response, addressing the issue of many unwitnessed cardiac arrests.

This technology could significantly improve the response to cardiac arrest patients and increase survival rates, especially for unwitnessed events. However, it has yet to be assessed in actual cardiac arrest cases.

We're stepping into a world where an unwitnessed cardiac arrest may be “witnessed” by a smartwatch, how will it be considered in the future?

We have commented more in details how this technology works and its implications in @ResusJournal: https://t.co/UxVeGKexZE

[Gianluca Paternoster @paternoster_g]

Angiotensin II increase blood pressure in adults with septic or other distributive shock.
How to use it in clinical practice:
https://t.co/RGXLw81mUP

@giovannilandoni @ElenaG_Bignami @fabiodoc64 @AndCorteg @KatiaDonadello