Chris Mapperley

Postdoc, Institute of Cancer Research | RNA modifications & AML therapeutics | Kranc Lab

[Chris Mapperley @MapperleyChris]

https://t.co/VVCKdKKev3

[Chris Mapperley @MapperleyChris]

Our latest paper on targeting TUT4/7 in acute myeloid leukaemia went live at 7PM, coinciding perfectly with the eclipse. A hike from work to watch and celebrate. More to follow tomorrow, thanks to everyone who contributed, @kamilkranc , @CarrollDonal and many, many others.

[Chris Mapperley @MapperleyChris]

https://t.co/AN0pLFHkJA

[Kamil R Kranc @kamilkranc]

Delighted to share our new work in @NatureCancer in collaboration with @SchofieldOxford led by @hannahjlawson & James Holt-Martyn. We found that HIF hydroxylases are potent therapeutic targets in AML. @ICR_London. https://t.co/cb3K90Wlot. 1/4

[Chris Mapperley @MapperleyChris]

Pre conference run #RNAUK2024. We're set up and looking forward to welcoming you!

[Paolo Gallipoli @PaoloGallipoli]

Preprint alert!
https://t.co/P2aqRezWEG

A very enjoyable work led by @VilmaDembitz perseverance and talent but also made possible by the help provided by a wide range of excellent senior and junior collaborators. A refreshing experience for a young academic! Thread 👇 1/10

[Celine Philippe @Celine1Philippe]

Very happy to have taken part to the inaugural EHA research conference @EHA_Hematology! Bravo to @VilmaDembitz, @hannahjlawson, @MapperleyChris, @SyedAMian for your amazing talks 🔥

[Hannah Lawson @hannahjlawson]

Great to give a talk @EHA_Hematology #ehaRecon22 in Palermo! A pretty amazing place to spend a few days talking science! @QMBCI @kamilkranc

[Bertie Gottgens @BertieGottgens]

A time and single-cell resolved model of hematopoiesis: https://t.co/nl5Fup1oCI. With @kamilkranc and @CarrollDonal groups, we have generated a new model of hematopoiesis, fit for the single cell genomics era, building on @fabian_theis group https://t.co/by7kWSFs41. @SCICambridge

[Paolo Gallipoli @PaoloGallipoli]

Please direct contact me if you are interested. Funding will be available to extend position further if needed and there are lots of interesting projects in the lab and scope for more in AML and cancer metabolism

https://t.co/6VF56K1a2p

[Diu Nguyen_vn_uk @diunguyen_vn_uk]

Research technician job is available in my group at Haemato-Oncology Centre, Barts Cancer Institute. Opportunity to work in a beautiful campus in the middle of London and wonderful scientists and physicians. Promise to fulfill your desire to learn! https://t.co/iCF3X2PXne

[Kamil R Kranc @kamilkranc]

So pleased to see our CITED2 paper out in @stemcellreports. We found that Cited2 deletion results in HSC loss via Mcl1 & Pten downregulation. Incredibly, we reveal that unperturbed hematopoiesis can be sustained long-term while the HSC pool is depleted! https://t.co/aABTqOxXGZ

[Kostas Tzelepis @TzelepisLab]

Very proud to announce our latest paper @nature showing the development and characterisation of the first-in-class catalytic inhibitor of METTL3 against AML. A superb collaboration between our lab (@TheMilnerInst, @sangerinstitute), @storm_tx and @TKLABUK
https://t.co/oy5Lf5wKkd

[Milner Therapeutics Institute @TheMilnerInst]

In a paper published today in Nature, see how exciting work at the Milner Institute, in collaboration with @storm_tx , has made a promising step towards developing a new drug for treating acute myeloid leukaemia.

https://t.co/gm4StWEkVl

@TKLABUK @TzelepisLab

[Chris Mapperley @MapperleyChris]

@RushworthLab Thanks Stuart, it was great to meet you!

[Chris Mapperley @MapperleyChris]

Fairly typical I manage to include a spelling mistake. Not representative of the thesis..... I hope.

[Chris Mapperley @MapperleyChris]

Thanks to my examinors @RushworthLab, @GrannemanSander and supervisors @kamilkranc, @CarrollDonal aparently i'm now a Dr! Now time for a drink and to change my passport.

[Kamil R Kranc @kamilkranc]

Congratulations to Dr @MapperleyChris for passing his PhD viva! Many thanks to Stuart @RushworthLab and @GrannemanSander for examining Chris and @CarrollDonal for great co-supervision. Good luck with your postdoc in HSC and RNA biology @QMBCI.

[Maria Christophorou @MAChristoLab]

Sometimes, to understand what something does you must first figure out what it doesn't do!

In the latest #preprint from our lab, we demonstrate that the peptidylarginine deiminase PADI4 is dispensible for cell-autonomous haematopoietic development
1/

https://t.co/I9dRwH1byG

[Donal O'Carroll @CarrollDonal]

The O’Carroll lab is looking for talented postdoctoral research associates to join us in our quest to explore piRNA-directed DNA methylation.
https://t.co/YptkH9tbkq

[Kamil R Kranc @kamilkranc]

Delighted to see our new paper in @bloodadvances. Many thanks to our collaborators and @bloodcancer_uk for funding this important research!