Review from the lab on lipid metabolism in AML just out @LeukemiaJnl
https://t.co/I17xisYFtl
Led by the hard work of @VilmaDembitz and @sophiejamess_
Hope you enjoy the read!
๐ฐ Researchers at BCI have uncovered a promising treatment for #leukaemia that targets the way cancer cells metabolise fat.
โก Read more: https://t.co/Vn0lUtTorr
@QMULBartsTheLon | @CRUKCOLcentre
๐ Investigators with Dr. @VilmaDembitz at @QMBCI identified stearoyl-CoA desaturase as prognostic of patients' outcomes and showed that SCD inhibition โ is a therapeutic vulnerability across multiple #AML models.
@LeukemiaJnl | https://t.co/fB9CdS1WNq
@PaoloGallipoli Thanks Paolo! It's great to see it published! And a big thank you to all our collaborators. This project was made possible by the joint effort of all of us!
Very proud to have participated in this phenomenal project! https://t.co/ORxb6OVG33 Congratulations to everyone involved but especially @hannahjlawson and @kamilkranc ! I hope this is just the first of many collaborations!
So happy to share our paper in @NatureCancer. https://t.co/uQCpE4gP4P We discovered that HIF hydroxylases are therapeutic targets in AML & with @SchofieldOxford showed that current or novel inhibitors (IOX5), selectively kill AML cells, and synergise with Venetoclax. 1/4.
Job advert alert!!!
๐
We have an exciting project to dissect the role of mannose metabolism in normal/AML stem cells using advanced in vitro and in vivo models.
https://t.co/n5NoooXPvN
Perfectly suited for an enthusiastic postdoc with interest in metabolism and in vivo models 1
Our recent work on mitochondrial folate metabolism in leukaemia is out in @NatureComms
Congrats to @Martha_Z for delivering this excellent work during her PhD ๐๐ฉ๐ปโ๐ฌ
Stay tuned for a la @Martha_Z tweetorial
@UofGCancerSci@UofGlasgow@CRUK_SI
https://t.co/bPIEETnYq5
In another piece of good news, I am pleased to say that our paper on how to model AML chemotherapy in NBSGW mice is now published @Hemasphere_EHA
https://t.co/Np6fy239GM
Job Advert alert ๐
A postdoctoral position in my lab. The project will leverage previous work and a recently performed CRISPR screen to optimise delivery of specific metabolic therapies in AML. If you are interested please DM me. Pls retweet
https://t.co/17bhIucUBJ
Preprint alert!
https://t.co/P2aqRezWEG
A very enjoyable work led by @VilmaDembitz perseverance and talent but also made possible by the help provided by a wide range of excellent senior and junior collaborators. A refreshing experience for a young academic! Thread ๐ 1/10