In #HeartMonth and on #WearRedDay I am pleased to announce a new PhD studentship in my lab to study and develop novel therapies to target cardiovascular disease development, application deadline March 6 for a October 2026 start, please RX:
https://t.co/RRvRsOs9HJ
✨ Thrilled to share our new publication in Nature.
We define an “inflammatory memory” HSC state (HSC‑iM), linking lifelong inflammatory exposure to aging and disease.
📄 Article: https://t.co/7OSZ7uNZHi
Grateful to an incredible team and global collaborators 💚💙
The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative breast cancer.
✓ out the new Ground Truths (link in profile)
Review series on clonal hematopoiesis: the driver mutations.
This review explores how driver mutations shape stem cell fitness and how inflammatory progeny may promote clonal advantage and disease risk.
https://t.co/7q6SFfgAKL
We published a new preprint on BioRxiv. We uncovered a pyroptosis-driven stromal-immune circuit that explains why TET2 mutations progress to myeloid disease, and how to disrupt it. This work is led by @Kehan_Ren_PhD. https://t.co/ey7DtOLBwI
Review series on clonal hematopoiesis: from CHIP to myeloid neoplasms.
What drives progression from clonal hematopoiesis to myeloid malignancy? This review explores risk, biology, and emerging therapeutic strategies.
https://t.co/bjU4t5hEoD
#AML world awareness day. AML symptoms can be mistaken with several other diseases but a simple blood test can give an early diagnosis and access to treatment. Sign up to @AnthonyNolan or @DKMS_uk to become a potential stem cell donor and save a life.
With Razan Aljohani at #BSH2026 Young EHA who is presenting her data on the role of Zeb1 in AML. Razan is coming to the end of her PhD at @ECSCRI and is showcasing data as part of her contribution to @bloodcancer_uk funded project led by @NRodriguesLab. 👏 Razan on your poster
Excited to be #BSH2026 in Liverpool. Attending Young EHA. @EllieMcCracken1 👏 has been selected to deliver an oral presentation on fusion gene roles in erythroid development funded by Myristica Trust @haematology_CU@MEDICPGR. Attending with Jess Mundy, aspiring researcher
Beautiful editorial highlighting Dr. T. Ray Bradley’s pivotal role in @ISEHSociety and Exp hematology. Thanks to @purton_louise, Susie, Ivan, Richard, and Toshio for early-HSC insights and Ray’s agar colony-forming cell assay, revealing BM progenitors.
https://t.co/3ST9Kbq5Q8
❓A one-time, durable, and even reversible way to prevent thrombosis? In this preprint, led by @lrbzldz, we show that epigenome editing of 🩸 #StemCells can durably reprogram platelet function: https://t.co/bioSZhRFuG
First (to my knowledge) manuscript describing a correlation between number of infections and incidence of clonal hematopoiesis (CHIP). Really important from the perspective of highlighting a possible modifiable driver of CHIP during aging. @ISEHSociety https://t.co/DRtk6ScrJt
In #HeartMonth and on #WearRedDay I am pleased to announce a new PhD studentship in my lab to study and develop novel therapies to target cardiovascular disease development, application deadline March 6 for a October 2026 start, please RX:
https://t.co/RRvRsOs9HJ
First of 2 important #PPI sessions today - great to bring @alex_tonks@NRodriguesLab & @ShuchiChromaBio together with 8 ppl affected by #AML /#MPNs really interesting & insightful discussion incl challenge of involving patients/carers in basic/lab based research @BloodCancer_Res