Marcel Werner

Postdoc in Anja Groth's group. Interested in DNA replication, epigenetics and cancer.

[Marcel Werner @marcel_werner24]

I am delighted to share the main work of my PhD project in the Hamperl lab now out in @NAR_Open. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.

https://t.co/4pQJ88zZ6X

Full thread on BlueSky 🦋 @ https://t.co/3GETur47Rd

[Molecular Cell @MolecularCell]

Online Now: Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability https://t.co/O7Ue4Lw1lq

[Marcel Werner @marcel_werner24]

@klysakovskaia @NatureSMB Congrats Kseniia! 🥳

[Kseniia Lysakovskaia @klysakovskaia]

Our paper is finally online in @NatureSMB 🎉we uncovered a transcription regulatory role of promoter-proximal Pol II termination during human cell type transition. Many thanks to everyone involved!!!

https://t.co/TMWWWRrwVK

[Marlies Oomen @meoomen]

Very excited that our paper is now online! https://t.co/btukyGSKHJ
Long thread on our findings on the other app 🦋

[Samah W. Awwad @SamahAwwad3]

Happy to share our newly published article in Nature Communications! In this work, we uncover the novel role of KLF5 in sensitizing cells to ATR inhibition, identifying it as a synthetic lethal partner with the tumor suppressor ARID1A. @SPJacksonGroup

https://t.co/0bHKUUitvP

[ME Torres-Padilla @METorresPadilla]

Truly honoured to received such a recognition - a deep, big thanks to current and former people from my lab, our collaborators, our funders and the people who support our work every day

[Helmholtz Munich | @HelmholtzMunich @HelmholtzMunich]

Maria-Elena Torres-Padilla Awarded the Leibniz-Preis 2025 🎉

👏 The German Research Foundation (#DFG) recognizes the outstanding research of Prof. Maria-Elena Torres-Padilla with Germany’s most prestigious scientific award: the Gottfried Wilhelm #LeibnizPreis.
👉https://t.co/BCyal9ZcXk

💡 The international top scientist from #HelmholtzMunich fundamentally changed our understanding of stem cell biology an early development.

With her groundbreaking "cells à la carte" approach, the Mexico-born scientist is pioneering innovative #therapies for diseases like neurodegeneration, brain injuries, and cancer.

👉Discover more in her #interview "Empowering Cells’ and Scientists’ Potential for Cell Therapies":
🔗https://t.co/EiNQHUPRDk

Prof. Matthias Tschöp, CEO of Helmholtz Munich, states:
💬 "Maria-Elena Torres-Padilla has fundamentally changed our understanding of early development and epigenetic regulation with her groundbreaking contributions to stem cell biology. Her scientific excellence and innovative thinking have had a profound impact on the field and inspires researchers worldwide. The Leibniz Prize is a well-deserved recognition of her exceptional achievements and lasting influence on biomedicine."

🌟 Why it matters:
Her work is not just science - it’s the foundation for future #PersonalizedMedicine and #RegenerativeTherapies.

About Maria-Elena Torres-Padilla:
✨Head of the Stem Cell Center (rotating), Helmholtz Munich
✨Director of the Institute of Epigenetics and Stem
Cells, Helmholtz Munich
✨Director of Biomedicine at @PioneerCampus
✨Professor at @LMU_Muenchen

@METorresPadilla @dfg_public @epigeneticsHMGU @MatthiasTschop

#Epigenetics #StemCells #Award #Research #ResearchPioneers

[Marcel Werner @marcel_werner24]

@zhnbkv_ai Congratulations!

[Marcel Werner @marcel_werner24]

Looking forward to presenting my work on chromatin disruption by transcription-replication conflicts today at #EESreplication. Find me at Poster 134!

[Marcel Werner @marcel_werner24]

@isaac_fianu @CaltechCCE @Caltech Amazing news, congrats Isaac! 🥳

[Ulrike Kühbacher @UKuhbacher]

🚀 Exciting news! Our latest paper reveals a novel function of HLTF in resolving G4 DNA structures and restraining DNA synthesis to maintain genome stability 🧬🔬https://t.co/jZ3v7OutFS… @KarleneCimprich @30xte

[Marcel Werner @marcel_werner24]

@AlexanderRotsch Congrats, Alex!🥳

[Martijn Luijsterburg @luijsterburglab]

New preprint with @KokicGoran and @SvejstrupLab! We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair.

Great teamwork by @dianavandenheu2 , @MartaRodrgzMart, and Paula van der Meer!

https://t.co/fdHjrAu67m
1/5

[Marcel Werner @marcel_werner24]

Wow! 🤯

[Patrick Hsu @pdhsu]

What if we could universally recombine, insert, delete, or invert any two pieces of DNA?

In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

[Marcel Werner @marcel_werner24]

I had an amazing time at the #EMBOchromatindynamics workshop in Leiden this week! Thank you everyone for making this such a great meeting.

[Marcel Werner @marcel_werner24]

@jentoft_ida @maxplanckpress @SchuhLab @mpi_nat Congratulations, Ida!🥳

[Marcel Werner @marcel_werner24]

Amazing to see that this fantastic work led by @taras_velychko is finally out! Very glad to have contributed to this story during my master thesis.

[Molecular Cell @MolecularCell]

Online Now: CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release https://t.co/S7qPe1puID

[Patrick Cramer @mpgpresident]

Pol II pausing depends on the +1 nucleosome (maintained by FACT) - link to the Paper by K. Zumer et al.: https://t.co/46Q5bACnja

[Marcel Werner @marcel_werner24]

Great story from @saponaro_m lab!

[Marco Saponaro @saponaro_m]

Our latest paper is out in @GenomeBiology!!! Here we present a method to identify genomewide hotspots where replication forks stall or pause. These sites are associated with increased DNA damage and overlap with breakpoints of cancer rearrangements https://t.co/LPBZIH3RMR