Maria Gonçalves

Neuroscientist & Public Health advocate. Music-botanic-philosophy lover. @WyssInstitute | @HarvardMed | @geochurch lab #NeuroImmunology #Aging

[Maria Gonçalves @Maria_CBG]

@amplesa @Harlan_Stevens1 👏👏 Congrats! Amazing work!

[Maria Gonçalves @Maria_CBG]

Amazing work, @Harlan_Stevens1 and @amplesa ! 🚀

[Harlan Stevens @Harlan_Stevens1]

Entropy is random. Its effects on aging are not.

Aging destabilizes the regulatory networks in blood stem cells🩸 But not every part breaks equally.

The hallmarks of blood stem cell aging trace to one thing: fragile TF programs collapse with age, while stable ones expand.
🧵1/8

[Maria Gonçalves @Maria_CBG]

@amplesa Well said!

[Existential Hope @HopeExistential]

https://t.co/fttbOTrm7j

[John Lukens @LukensJohnR]

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition. https://t.co/k72B7OdPIh

[Neuron @NeuroCellPress]

Online now: Astrocyte-microglia crosstalk through Hevin and Toll-like receptor signaling controls developmental thalamocortical synapse refinement https://t.co/Y5Hk1CznUp

[Dr. Dominic Ng @DrDominicNg]

New Cell paper from the team that discovered glymphatic clearance (how your brain removes waste during sleep).

Sleep hours DIDN'T predict brain cleaning. Neither did REM or deep sleep.

They found what actually matters - and why some sleeping pills might undermine it 🧵

[Raphael Ferreira @ferreira_raph_]

I’m hiring a PhD student!

Come work on #CRISPR + Cancer + T cells 🧬 and help push the boundaries of next-gen immunotherapy. Join us in Copenhagen 🇩🇰 at @DTU_HealthTech !!!
Deadline: 30 Sept 2025
https://t.co/XnQ2IuaNPR

[Cell Reports @CellReports]

Plasma extracellular vesicle surface-located GAS6/PROS1 and CD39/CD73 attenuate inflammation https://t.co/UCyGu8u649

[John Lukens @LukensJohnR]

Alzheimer’s disease transcriptional landscape in ex vivo human microglia
@NatureNeuro
https://t.co/OUp5XrQ7Br

[Maria Gonçalves @Maria_CBG]

Congratulation @ferreira_raph_ !
Amazing work 🤯

[Jonas Koeppel @JonasKoeppel]

I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases @ScienceMagazine!

@ferreira_raph_ @LeopoldParts @ProfTomEllis, @geochurch @SangerInstitute

https://t.co/UtJ13iNRAq

Lots of changes from the preprint. A🧵

[Ali Max Erturk @erturklab]

Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵👇@cellhostmicrobe https://t.co/IEGx7HIrXf

[Maria Gonçalves @Maria_CBG]

Our latest work is out in #JExBio! 🧪

If you work with human specimens, you know how crucial it is to determine the best methods to ensure accurate and reproducible analyses—especially when studying those tiny little buddies called #EVs and #miRNAs 🤏

Congrats, team!

[ISEV-Journals @ISEV_Journals]

🆕New in #JExBio🆕 This study investigates how the choice of blood collection methods influences EV size, abundance, antigenic composition and miRNA content. Read the full text here 👇https://t.co/UmreILrqjn

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

[The Nobel Prize @NobelPrize]

#OnThisDay in 1903, Marie Skłodowska Curie defended her doctoral thesis on radioactive substances at Université de la Sorbonne in Paris – becoming the first woman in France to receive a doctoral degree in physics.

[Broad Institute @broadinstitute]

Join us tomorrow, 5/21 at 6pm ET, online or in person, for a discussion of the past & future of psychiatric diagnosis & care. Register: https://t.co/XlBgnrSisD

Learn about our panelists ⬇️🧵

[Maria Gonçalves @Maria_CBG]

👏👏 Dr Wong! @ireneGLwong

[Harvard Medical School @harvardmed]

#HarvardMed24 PhD grad Irene Wong investigates lung regeneration while training and supporting young scientists from diverse backgrounds https://t.co/aVPTluXbUe

[nature @Nature]

Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response https://t.co/N9cljNPS3R

[Maria Gonçalves @Maria_CBG]

@ireneGLwong @harvardmed @BBS_Harvard @drb_hms Yay! Congrats Dr!

[John Lukens @LukensJohnR]

Microglia-derived extracellular vesicles trigger age-related neurodegeneration upon DNA damage | PNAS https://t.co/RrdyWAwjMs