Marie Warrer Munch

MD, ph.d.-student, Intensive Care Unit, Rigshospitalet
Coordinating investigator of COVID STEROID 2 trial

[Intensive Care Medicine @yourICM]

Dexamethasone in #COVID19 & severe hypoxaemia: with 12 vs 6 mg
💉high probabilities of benefit on all outcomes, including days alive without life support/mortality
💉relatively low probabilities of important harm
COVID STEROID 2 trial bayesian analysis
https://t.co/4LwbOxhgfs

[Marie Warrer Munch @marie_warrer]

@RWahlin Thank you, and also a big thanks to you, Rebecka 😀

[Marie Warrer Munch @marie_warrer]

The COVID STEROID 2 trial results out now. A huge thanks to everyone involved in the trial. Amazing team effort getting here 🇩🇰🇮🇳🇸🇪🇨🇭
Also a BIG thanks to @CritCareReviews for hosting a great panel discussion of the trial results last night.

[JAMA @JAMA_current]

In a randomized trial of patients with #COVID19 and severe hypoxemia, compared with 6 mg of dexamethasone, 12 mg of dexamethasone did not statistically significantly reduce the number of days alive without life support at 28 days https://t.co/1GML3s4BoF

[Marie Warrer Munch @marie_warrer]

@Acute_Pulmo_Med @CritCareReviews Agree, that would be very interesting, but unfortunately, we do not have plasma samples from the trial participants 😔

[Marie Warrer Munch @marie_warrer]

@NaomiHammond @CritCareReviews Thanks so much for the kind words 😀

[CRIC @CRIC_Int_Care]

The #COVID_STEROID_2 has enrolled 321/1000, thanks to all investigators for taking the time to help improve the care of COVID-19 patients during this pandemic! Welcome to Respiratory Medicine at Hvidovre/DK and Slagelse/DK, who enrolled their first patient💪 Happy New Year 🥳🍾🥂

[CRIC @CRIC_Int_Care]

Congratulations to all investigators for reaching a new milestone in the COVID STEROID 2 trial: patient no. 200 has just been randomised at Herlev ICU, Denmark. The trial is now recruiting from 11 Danish, 8 Indian and 1 Swiss site. More sites to join soon. #COVIDSTEROID2

[CRIC @CRIC_Int_Care]

Congratulations to S.L. Raheja Fortis Hospital in India for randomizing their first patient to the COVID STEROID 2 trial. 76 patients enrolled and 924 to go before gaining knowledge on lower vs. higher dose of Dexamethasone for COVID-19 patients with hypoxia #COVIDSTEROID2

[CRIC @CRIC_Int_Care]

Amazing last hours for the COVID STEROID 2 trial - 15 patients enrolled! Thanks to all sites, especially thanks to the two new sites Rajendra Institute of Medical Sciences, Ranchi, India and Thoracic ICU, Rigshospitalet, Denmark. #COVIDSTEROID2 @AndersPerner @MarieWarrer @Majkja

[CRIC @CRIC_Int_Care]

Congratulations to Hillerød and Odense ICUs for randomising their first patients into the COVID STEROID 2 trial.
28 out of 1,000 patients with COVID-19 have now been randomised to higher or lower doses of dexamethasone at 8 Danish and 2 Indian sites @BestleMorten #COVIDSTEROID2

[CRIC @CRIC_Int_Care]

Now 6 Danish sites and 2 Indian sites have enrolled 23 patients into the COVID STEROID 2 trial. The latest site to enroll patients is the ICU in Køge (Denmark) - great job @MusaeusPoulsen. #IntensiveCareTrial #COVIDSTEROID2 @AndersPerner @MarieWarrer

[CRIC @CRIC_Int_Care]

Congratulations, to Kolding ICU, Aalborg ICU and Hvidovre Infectious Diseases for randomisering their first patients to the COVID STEROID 2 trial assessing higher vs. lower doses of dexamethasone in patients with COVID-19 and severe hypoxia #IntensiveCareTrial #COVIDSTEROID2

[CRIC @CRIC_Int_Care]

Congratulations Hvidovre in Denmark. This is the second site in Denmark enrolling patients in the COVID STEROID 2 trial. Nine patients enrolled, 991 to go. #COVIDSTEROID2 @vibebenfield @TjelleKlaus @AndersPerner @MarieWarrer

[covid steroid @CovidSteroid]

First patient enrolled in the COVID STEROID Trial. Goal is to find out what is the best treatment for patients with COVID-19 and hypoxia: Low dose hydrocortisone or placebo (Saline). #COVID19 #clinicaltrials @AndersPerner @MarieWarrer