Mario Leutert

#proteomics | #Signaling | #PTMs | #phospho | #SystemsBiology | #TeamMassSpec

[Mario Leutert @MarioLeutert]

Excited to share our newest #preprint: Multidimensional proteomics identifies molecular trajectories of cellular aging and rejuvenation.

A great project with the @juditvr @DunhamLab @mkaeberlein teams!

📄Read: https://t.co/i78BXLFrdL
💾Explore: https://t.co/ZVlUGMAVnn
1/9

[David Bradley @dbradley534]

Feeling pretty psyched to see a major work from my postdoc now published, this time in @embojournal

We examine the fitness cost of spurious phosphorylation, with major additions over the 2023 preprint: https://t.co/354VPJWLTC

My tweetorial is below (1/n)

[Pedro Beltrao @pedrobeltrao]

The #SignallingAlliance seminar series continues today at 3pk UK, 4pm CET. Today we have talks by @MarioLeutert and @fabfrohlich Free to watch at https://t.co/mlSMDCXWJP

[Evangelia Petsalaki @e_petsalaki]

This Thursday! Note the slight change of plans with Mario Leutert representing the @juditvr group.Looking forward to two exciting #SignallingAlliance talks!

[IBFG @ibfg_es]

#IBFG_External_Seminar | Join us on January 19th for a seminar entitled "Deciphering Regulatory Protein
Networks in Aging and Stress Signaling" by @MarioLeutert, a researcher from @IMSB_ETH.

🔑Free Access
⌚️12.30 pm
📍 IBFG Conference Room

More info👇

[Marc van Oostrum @Marc_vOo]

Ever wondered how the #proteomes of different #synapse types vary? 🧠Our latest study from @erin_schuman lab published at @CellCellPress reveals the #diversity across 18 distinct synapse types👇@MpiBrain 💰@snsf_ch ⚖️#TeamMassSpec 💾https://t.co/DaqUejxLjy https://t.co/uz6QW31h1G

[Mario Leutert @MarioLeutert]

For a breakdown of the study check out the news and views article:
https://t.co/dgwePfhpTz
and the previous tweetorial: https://t.co/TNatCNhp5O

[Mario Leutert @MarioLeutert]

Excited to share our work on high-dimensional #phosphoproteomics in yeast exposed to >100 environmental and chemical perturbations. This is one of the largest and most systematic perturbation-phosphorylation resources for any species. #TeamMassSpec (1/8)

[Mario Leutert @MarioLeutert]

Very happy to share our extensive and systematic Phosphoproteomic Stress Signaling Atlas that is now published @NatureSMB:
https://t.co/lEseL8nwB5
Thanks to the @juditvr lab and co-autors @AnthonyBarente , Noelle Fukuda & @RRodriguezMias!
#proteomics #signaling #TeamMassSpec /1

[Pedro Beltrao @pedrobeltrao]

There are a number of open questions in cell signalling that require a systems level view. Our Signalling Alliance webinar series will pair experimental and computational groups exploring these questions. Join us online.

[Riddhiman Garge @riddhimankg]

Thrilled to share our work profiling Ale yeast protein dynamics across fermentation and serial repitching! https://t.co/Lu2CL80Lxd @DunhamLab @edward_marcotte @LiveOakBrewing #BeerYeast #SystemsBiology #Proteomics Sneek Peak thread🧵 below

[Savitski Lab @savitski_lab]

We are happy to present our workflow DQGlyco enabling the in-depth quantification of glycoproteome dynamics. In total, we characterize > 150,000 glycoforms in the mouse brain. https://t.co/hRDnvzORkS

[Julian van Gerwen @JulianvanGerwen]

Out now in @eLife: We explore how genetics and environment rewire muscle insulin signalling

Featured here: https://t.co/s9rTrI9AMU

Available here: https://t.co/i1Avv6tbtG

A thread

[Pedro Beltrao @pedrobeltrao]

How many different protein shapes are there in 200 million predicted AlphaFold structures? In a joint project with @thesteinegger we (@ibarrioh, @jgyyy15
et al) clustered these into around 2 million groups to study their novelty and evolution https://t.co/e2lMGt3Dvw

[David Bradley @dbradley534]

I am truly excited to share one of the major works to emerge from my postdoc, now on bioRxiv:
https://t.co/Y2YHSCM7Rx

We explore the role of differential 'substrate quality' on the phosphorylation of kinase targets, using as our case study the master kinase CK2 (1/n).

[Cristina Viéitez (@crisvieitez.bsky.social) @Cris_Vieitez]

We are looking for a #PhD candidate! Are you interested in #chromatin and want to combine high-throughput methods & molecular biology to understand how histone #PTMs regulate chromatin functions using #yeast? 👩‍🔬🧑‍🔬🧫🧬 Contact us 👇Please spread the word!

[Mario Leutert @MarioLeutert]

Excited to attend #ASMS2023 and present our approach to study cellular aging using multidimensional proteomics:

[Mario Leutert @MarioLeutert]

The method might be cheap, but the data is priceless.

[Alexis Chang @alexischang3000]

Here's what happens when you start working with a postdoc & scientist too cheap to buy reagents: @MarioLeutert @RRodriguezMias

Checkout our automated and cost effective phosphotyrosine enrichment protocol now in JPR!
@juditvr Villen Lab, UW
https://t.co/ELOeavbuTq

[Christoph Messner @chr_messner]

Our Yeast 5k Proteome Project is now published in Cell.

We measured proteome profiles for almost 5,000 single knock-out yeast strains. We show what drives protein changes and how this resource can be used for functional annotation of genes and proteins.
https://t.co/TPC8qQqu7a

[Mario Leutert @MarioLeutert]

@PNanni_ @UCDProteomics @CaTFFranco @StoyanStoychev1 And very modular. For example @alexischang3000 developed a phosphotyrosine peptide enrichment protocol to add on top: https://t.co/q4QSdSqy4r

[FGCZ @FGCZ_EN]

Do you want to see how #AlphaFold2 can be applied to study protein-protein interactions? Join us for a new #FGCZseminar where @pedrobeltrao will show its potential and limitations.
April 25th, 16:00-17:00
Registration required
Apero will follow
#proteomics, #interactionproteomics

[Mario Leutert @MarioLeutert]

This was an amazing team effort between the labs of @juditvr , @DunhamLab , @mkaeberlein with contributions from Joe Armstrong, @AnjaOllodart , Kyle Hess, Michael Muir and @RRodriguezMias . 9/9

[Mario Leutert @MarioLeutert]

Excited to share our newest #preprint: Multidimensional proteomics identifies molecular trajectories of cellular aging and rejuvenation.

A great project with the @juditvr @DunhamLab @mkaeberlein teams!

📄Read: https://t.co/i78BXLFrdL
💾Explore: https://t.co/ZVlUGMAVnn
1/9

[Mario Leutert @MarioLeutert]

We show numerous examples of age-affected processes in our study and anticipate that our resource will be useful for studying the basic biology of aging. Explore how the properties of your favorite protein are impacted by age here: https://t.co/I0ivnvjXMu 8/9