Judit Villen

Proteomics, mass spectrometry, systems biology
Professor at UW Genome Sciences
Mother, runner, outdoor enthusiast

[Judit Villen @juditvr]

Very proud of fearless graduate student @alexischang3000 for facilitating HT phosphotyrosine studies through this method.

[Alexis Chang @alexischang3000]

Here's what happens when you start working with a postdoc & scientist too cheap to buy reagents: @MarioLeutert @RRodriguezMias

Checkout our automated and cost effective phosphotyrosine enrichment protocol now in JPR!
@juditvr Villen Lab, UW
https://t.co/ELOeavbuTq

[Judit Villen @juditvr]

How cells age? How they remain young? How they rejuvenate? We were amazed on how combining the multiple proteomic assays can yield mechanistic insight into the basic biology of aging , e.g. regarding asymmetric division, organelle partition, and trajectories of protein complexes.

[Mario Leutert @MarioLeutert]

Excited to share our newest #preprint: Multidimensional proteomics identifies molecular trajectories of cellular aging and rejuvenation.

A great project with the @juditvr @DunhamLab @mkaeberlein teams!

📄Read: https://t.co/i78BXLFrdL
💾Explore: https://t.co/ZVlUGMAVnn
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[Mario Leutert @MarioLeutert]

Excited to share our newest #preprint: Multidimensional proteomics identifies molecular trajectories of cellular aging and rejuvenation.

A great project with the @juditvr @DunhamLab @mkaeberlein teams!

📄Read: https://t.co/i78BXLFrdL
💾Explore: https://t.co/ZVlUGMAVnn
1/9

[Judit Villen @juditvr]

Happy to share new preprint from superstar postdoc @MarioLeutert in my lab. One of a kind phosphoproteomic study (101 perturbations x 6) enabling cool analyses and novel discoveries in signaling. The regulatory landscape of the yeast phosphoproteome https://t.co/pugQnxZEZ9

[Judit Villen @juditvr]

Mistranslation + biochem assays + MS = variant interpretation across the proteome. Innovative idea by @RRodriguezMias and co-developed with @noncanonikyle, and many other contributors from Villen, Fields and Noble lab. MiRo: MistranslationRocks

[Judit Villen @juditvr]

I am very excited to share the latest technology from my lab.
Proteome-wide identification of amino acid substitutions deleterious for protein function https://t.co/P6BisKmlko

[Judit Villen @juditvr]

I am missing #ASMS2021 this year. But several cool presentations from students and postdocs in my lab on phosphoproteomics, MS acquisition methods, and functional annotation of protein variants @AnthonyBarente @MarioLeutert @AlexHgO @smithianr @noncanonikyle

[Mario Leutert @MarioLeutert]

Excited to share our review on PTM crosstalk @molcellprot with @sam_entwisle @juditvr ! We discuss the basic modules of PTM crosstalk and focus on emerging technologies to study PTM crosstalk proteome-wide! #Proteomics #TeamMassSpec https://t.co/aNOVGATHI5

[Judit Villen @juditvr]

"With science, numbers speak much louder than words." https://t.co/mKPF6xaFtS

[Judit Villen @juditvr]

@dlswaney @ProteomicsNews @uniprot @NCBI That is great Dani! Looking forward to learning from this data.

[Shao-En Ong @shaoenong]

My lab is looking for new postdocs and research scientists (https://t.co/km0eYoyMu2) interested in kinase signaling, EMT, cancer, and proteomics. Please RT!

[Lara Muffley @LaraMuffley]

The Center for the Multiplexed Assessment of Phenotype is excited to announce the launch of our new #Internship! This will be a unique opportunity to work with a team of scientists at the cutting edge of genomics and proteomics. Learn more at https://t.co/BiIqdjX6NZ

[Mol Syst Biol @MolSystBiol]

01/2020 Issue --> https://t.co/FkDTGYBHWI
The cover (by @TeamSciStories) highlights two automated sample preparation methods for #phosphoproteomics -R2-P2 from @juditvr @uwgenome- & #clinicalproteomics -autoSP3 from J Krijgsveld @DKFZ-
#proteomics

[Judit Villen @juditvr]

See also accompanying paper by @savitski_lab https://t.co/Hs36Zmz8Wg

[Judit Villen @juditvr]

Phosphoproteomics has catalogued 100,000s phosphosites. Can we pinpoint which are functional? We compare thermal stability of proteins and phosphoproteins to identify phosphosites altering structure and/or interactions.
https://t.co/S2MdhhVRsH

[Mol Syst Biol @MolSystBiol]

New automated end‐to‐end phosphoproteomic sample preparation method for multidimensional #CellSignaling studies --> https://t.co/jecRHJ7lKU from @juditvr @uwgenome
#proteomics #phosphoproteomics #MSBmethod

[Judit Villen @juditvr]

@shaoenong Very exciting to see this put together. Amazing resource. Congrats!

[Nature Methods @naturemethods]

Thesaurus, from @juditvr and colleagues: a new proteomics search engine that finds phosphopeptide positional isomers from PRM and DIA mass spec data. https://t.co/8anEB64SQ5

[Judit Villen @juditvr]

@Lange_Lab @MarioLeutert @RRodriguezMias We are not there yet, but peptide IPs for phosphoTyr, and other PTMs are in the pipeline.

[Judit Villen @juditvr]

New preprint from the Villen lab: R2-P2 method for automated phosphoproteomic sample preparation from cell lysates and application to MAPK signaling; work led by @MarioLeutert with contributions from Noelle Fukuda and @RRodriguezMias https://t.co/4RA14m2Bp7

[Judit Villen @juditvr]

Facilitating phosphoproteomics analysis of hundreds of samples with robust and reproducible high throughout sample prep.