Mary

[Mary @marisylva87]

@FZgroup_ @LatinXChem Of course Dr.
Melatonin stands out for its important anti-cancer properties. It can slow the evolution of cancer at different stages of the tumor cycle. But pharmacokinetic studies have revealed that MLT treatment is limited due to its relatively low oral bioavailability (3-15%).

[Mary @marisylva87]

Hi @LatinXChem, presenting my work ‘NEW MELATONIN-COUMARIN HYBRIDS: DESIGN, SYNTHESIS, CYTOTOXIC EVALUATION AND ADME PROPERTIES’ at #LatinXChem23 #Org064 #LatinXChemOrg

[Mary @marisylva87]

@humefigueroa @LatinXChem That's right Dr Humberto, we hope that the hybrid molecules have a synergistic effect in their mode of action on the therapeutic target.
Thank you very much for your appreciation.

[Mary @marisylva87]

@humefigueroa @LatinXChem Thank you very much Dr. Humberto for your question.
We expect that melatonin acts in the inhibition of the VEGFR growth factor or in some of the targets reported for melatonin in cancer, as well as the targets reported for coumarins as kinase inhibitors.

[Mary @marisylva87]

@JeremyMCarr @KAELMEUR @LatinXChem Hahahaha that's a very good idea to name the molecules, it makes a lot of sense! 😂
I also hope to soon be able to publish my work. Thank you very much for your appreciation.

[Mary @marisylva87]

@mafernan9 @LatinXChem Hello Marieta, thank you for your question!
We have found that possibly optimizing the reaction time or the base equivalents (K2CO3) can improve performance
The greater activity in the para position than in the ortho is possibly due to steric effects or hydrogen bond interactions

[Mary @marisylva87]

Hi @LatinXChem, presenting my work ‘NEW MELATONIN-COUMARIN HYBRIDS: DESIGN, SYNTHESIS, CYTOTOXIC EVALUATION AND ADME PROPERTIES’ at #LatinXChem23 #Org064 #LatinXChemOrg

[Juan Camilo Ramírez Bedoya @MiloRamirez_b]

Hi @LatinXChem, this is my work to #LatinXChem23 #LatinXChemOrg "Nuevos híbridos moleculares basados en cumarina-chalcona: Síntesis y Cálculos farmacocinéticos"

[Sara Melisa Gutiérrez Palacio @saram0802]

Hi @LatinXChem , this is my work "Developing hybrids based on melatonin/isatin/hydrazone: Design, synthesis, and drug-likeness studies" at #LatinXChem23 #LatinXChemOrg #Org050 #Synthesis #OrganicChemistry #MedicinalChemistry #Cancer

[Andrés Monsalve @mo54251772]

Hello @LatinXChem, here's my contribution to #LatinXChem23 'Synthesis and druglikeness of novel hybrids based on umbelliferone-combretastatin A-4' #LatinXChemOrg #Org051 @OrgBiomolChem @EurJOC @beyondbenign @green_rsc @RSC_Sus

[RUBEN DARIO BECERRA QUINTANA @dario_rube37486]

Hi @LatinXChem, this is my work "Hybrids based on benzofuran-stilbenes nuclei: Design, synthesis and Drug-likeness studies" at #LatinXChen23 #LatinXChemOrg #Org137 #Synthesis #OrganicChemistry #MedicinalChemistry #Cancer