Sara Melisa Gutiérrez Palacio

[Sara Melisa Gutiérrez Palacio @saram0802]

@JulietaCoro @quimicuba2024 Además del cambio en la fuente de energía (MW o US), también podríamos evaluar diferentes fuentes de protón, cambiando el AcOH por otro tipo de ácidos, como por ejemplo, H2SO4, HCl, H3PO4, HNO3 o HCOOH.

[Sara Melisa Gutiérrez Palacio @saram0802]

Hola #QUIMICUBA2024 #QC2024Organic
este es mi trabajo titulado "DEVELOPMENT OF NOVEL TRICONJUGATES FUSING MELATONIN/ISATIN/N-ACYLHIDRAZONE TARGETING COLORECTAL CANCER".

[Sara Melisa Gutiérrez Palacio @saram0802]

@JulietaCoro @quimicuba2024 Estimada compañera Julienta, respondiendo a tu pregunta relacionada con la optimización de los % de rendimiento te cuento que una de las altenativas que hemos venido estudiando es la de evaluar diferentes fuentes de energía como MW o US en el paso de la condensación.

[Sara Melisa Gutiérrez Palacio @saram0802]

@JulietaCoro @quimicuba2024 Para demostrar que si hay una relación directa entre la naturaleza de los sustituyentes y el % de rendimientos tendríamos que realizar una serie de híbridos en donde se prenten grupos -OH, -NH2, -OCH3 en las diferentes posiciones del anillo para demostrar la hipotesis mencionada.

[Sara Melisa Gutiérrez Palacio @saram0802]

@JulietaCoro @quimicuba2024 Estimada compañera Julieta, muchas gracias por tus preguntas.
Con respecto a la diferencia en los rendimientos de reacción de los diferentes híbridos obtenidos, notamos una ligera tendencia por la disminución en los % de rendimiento ante la presencia de grupos electrodonadores.

[DANIELA ANDREA CHAPARRO CÁRDENAS @CardenasDa11606]

Hi @LatinXChem , this is my work "Hybrids based on benzofuran-biphenyl nuclei: Design, synthesis and pharmakokinetic properties" at #LatinXChem24 #LatinXChemOrg #Org094 #Synthesis #OrganicChemistry #MedicinalChemistry #Cancer #Hybrids

[PEDRO ALEJANDRO MARTINEZ PÉREZ @Pedro_A_Chem]

Hi @LatinXChem, presenting our work “Regio selective synthesis of aryl genistein derivatives via the Chan-Evans-Lam reaction”at #LatinXChem24 #LatinXChemOrg #Org084 #NaturalProducts #OrganicChemistry #OrganometallicChemistry

[Sara Melisa Gutiérrez Palacio @saram0802]

@DiegoRo70181684 @LatinXChem Hi Diego, thank you for your questions.
We used SwissADME to calculate the pharmacokinetic parameters.
We haven't evaluated LogS or PHOA, yet. However, we are working on that.

[Sara Melisa Gutiérrez Palacio @saram0802]

Hi @LatinXChem , this is my work "Developing hybrids based on melatonin/isatin/hydrazone: Design, synthesis, and drug-likeness studies" at #LatinXChem23 #LatinXChemOrg #Org050 #Synthesis #OrganicChemistry #MedicinalChemistry #Cancer

[Sara Melisa Gutiérrez Palacio @saram0802]

@Resendizlab @LatinXChem Nevertheless, more studies are needed to provide a plausible explanation about this behavior, for instance, double-incorporating of -NH2 and -OH at C2, C3, and C4 positions.

[Sara Melisa Gutiérrez Palacio @saram0802]

@Resendizlab @LatinXChem Yes, appears to be there is a negative effect in the yields when electron donating substituents are present. We think that this effect is affecting the reactivity at long chain of NH2 group during the condensation reaction.

[Sara Melisa Gutiérrez Palacio @saram0802]

@Resendizlab @LatinXChem Hi Resendiz Lab, thank you for your questions.
The scale in which the compounds were obtainen was miligrams.
And the idea with incorporate the thio-group was because I found that two FDA's approved drugs (Triapin and Marboran) contains this core.

[Sara Melisa Gutiérrez Palacio @saram0802]

@arrflo @LatinXChem Hi Areli.
No, I observed other byproducts but they don't formed with more preferentially and don't have the R.f expected. Futhermore, the NMR's spectrums (¹H and ¹³C) are agree on the chemical structures of the anticipated product.

[Mary @marisylva87]

Hi @LatinXChem, presenting my work ‘NEW MELATONIN-COUMARIN HYBRIDS: DESIGN, SYNTHESIS, CYTOTOXIC EVALUATION AND ADME PROPERTIES’ at #LatinXChem23 #Org064 #LatinXChemOrg

[Juan Camilo Ramírez Bedoya @MiloRamirez_b]

Hi @LatinXChem, this is my work to #LatinXChem23 #LatinXChemOrg "Nuevos híbridos moleculares basados en cumarina-chalcona: Síntesis y Cálculos farmacocinéticos"

[RUBEN DARIO BECERRA QUINTANA @dario_rube37486]

Hi @LatinXChem, this is my work "Hybrids based on benzofuran-stilbenes nuclei: Design, synthesis and Drug-likeness studies" at #LatinXChen23 #LatinXChemOrg #Org137 #Synthesis #OrganicChemistry #MedicinalChemistry #Cancer

[Andrés Monsalve @mo54251772]

Hello @LatinXChem, here's my contribution to #LatinXChem23 'Synthesis and druglikeness of novel hybrids based on umbelliferone-combretastatin A-4' #LatinXChemOrg #Org051 @OrgBiomolChem @EurJOC @beyondbenign @green_rsc @RSC_Sus