Mart

[Mart @Mart64424191]

@drjamesgalloway #rheumjnlclub Interestinf isn't it. Inflammation and anti-inflammatory therapy in cardiovasculair events remains important, but insufficiently addressed as yet. In the end Rheumatology is every thing within a mile of a joint

[Mart @Mart64424191]

@chriswincup #rheumjnlclub In recent gout between attacks patients will be without major complaints and difficult to motivate to give a lot of information. In longstanding untreated gout. flares tend to be longer and intervals become more painfull. This need improvements in study design

[Mart @Mart64424191]

@SpaetgensB @chriswincup @SteZhao @drdj #rheumjnlclub indeed time to improvement was an important outcome in the ATTACK study, most relevant for patients

[Mart @Mart64424191]

@SpaetgensB @chriswincup @SteZhao @drdj # rheumjnlclub This is completky correct. In the Attack study time to improvement was an important outcome very relevant for patients

[Mart @Mart64424191]

@SteZhao #rheumjnlclub NRS is simple and easy to use in clinical practice. However measurement properties are disappointing as you will know. bottom and ceiling effect and no-lineair relations, where our statistic are mostly dealing with VAS and NRS as lineair relations

[Mart @Mart64424191]

@drdj @chriswincup #rheumjnlclub I hope that we will incorporate this in our registry and we will use it in a pragmatic Real World study comparing T2T versus Treat to symptom if we obtain funding

[Mart @Mart64424191]

@SteZhao #rheumjnlclub Great remark Steven. Obviously the 3 items will have different weights, we need much more data to calculate those weights driven by data.

[Mart @Mart64424191]

@drdj @chriswincup @rheumjnlclub standarisation is great but difficult to realise. If all colleagues capture all data on PROs in gout in their original data format and not only the final score IRT can help us to compare and merge data

[Mart @Mart64424191]

@drdj @SpaetgensB #rheumjnlclub Difficult to say as we speak. I think using smart devices, it would be great If patients complete it daily during each attack. Will be excellent data to address outstanding questions

[Mart @Mart64424191]

@chriswincup #rheumjnlclub. we will communicate our findings

[Mart @Mart64424191]

@SteZhao @RheumJnl #rheumjnlclub As I tweeted, not to the best of my knowledge. We are considering to use it in the GOUT registry. Prospective REAL WORLD data will enable us to improve and better understand the GAIS

[Mart @Mart64424191]

@SpaetgensB @rheumjnlclub may be for inflammation biomarkers will prove to be the best measurement options

[Mart @Mart64424191]

@SpaetgensB #rheumjnlclub Bart very good question. As you stated in your editorial there is a poverty of knowledge on methodology of gout studies as well as instruments. The first goal of the GAIS is to try to simplify and improve measuring gout flares in studies.

[Mart @Mart64424191]

@drdj @RheumJnl #rheumjnlclub Yes This is Mart van de Laar

[Mart @Mart64424191]

@RheumatologyUK #rheumjnlclub. This is Mart van de Laar co-author of the GAIS paper: waiting for the start of the journal club