3/ This PhD would suit candidates with backgrounds in epidemiology, biostatistics, bioinformatics, data science, genetics, computational biology, medicine or related quantitative/biomedical disciplines.
Interested candidates: please get in touch for an informal discussion.
A great new resource for phenome-wide genetic explorations by the Estonian Biobank🇪🇪🧬
👉206,159 participants
👉GWASs for 4,884 ICD-10 diagnoses
👉2,127 unique GWAS loci
👉778 putatively novel locus-phenotype associations
A GWAS meta-analysis for sarcoidosis in 9,755 cases and 1,526,867 controls🧬
In diseases like sarcoidosis, where we know little about etiology, GWAS can be much more interesting, as they provide pathogenesis insights with potential for informing therapeutic strategies
#PhysicalActivity for those with chronic widespread pain & #fibromyalgia effective in
✅Reducing #pain & #depression
✅Enhancing quality of life
🔹Intense physical activity has strongest protective effect
#MetaAnalysis
👉🏽https://t.co/tDfyziRZv2
The largest #GWAS of #sarcoidosis to date identifies 28 susceptibility loci and implicates CCDC88 and #TYK2* genes.
MR suggested causal roles of IL-23R and IL-2Rβ, and risk increasing role of #BMI. @Yuan_AS
https://t.co/J9OhEFhuFc
This study compares #apremilast and #methotrexate (that have more similar efficacy for cutaneous psoriasis) to see if targeted therapy reduces PsA risk independent of skin control.
However, a key limitation is that IL-17/-23 inhibitors have superior efficacy for controlling cutaneous disease, the severity of which is an independent risk factor for PsA onset.
🚨The incidence of #uveitis and #IBD in psoriatic disease, and vice versa, is not well described.
This study shows, among other things, that uveitis and IBD incidences are higher in #PsA than cutaneous-only #psoriasis and higher in females than males.
https://t.co/gF8yKJ3poq