Martin Holub

PhD Bioengineering |
science + technology | startups + venture | talks biotech, biosecurity, synbio |
over at 🦋 as

[Martin Holub @martinxholub]

* There is no demonstration of using the model for generative design, something that will hopefully be done in a follow up publication.

👏 Overall a nice piece of work! Thumbs up.

🔗: https://t.co/i9fjk2aHKd

#proteinengineering #proteindesign #enzymology #microfluidics

[Martin Holub @martinxholub]

"Evolutionary-scale enzymology enables exploration of a rugged catalytic landscape" - a paper from the labs of Margaux Pinney and Michael Keiser is out in @ScienceMagazine, showcasing a cool hardware tech and advances in models for enzyme property prediction. Some highlights: 1/n

[Martin Holub @martinxholub]

* Training a ProteinNPT (PNPT), a pseudogenerative model that jointly learns from protein sequences and property annotations (here with Transception embeddings), led to yet better predictions, in particular when prediction properties jointly.

[Felix Horns @FelixHorns]

Want to sequence RNA from cells without killing them or deliver RNA programs from cell to cell? Today in Cell, we present RNA exporters, which package and secrete cellular RNA, for non-destructively monitoring cell dynamics by sequencing and delivering RNA https://t.co/JG1mzYvLgb

[Jim Haseloff @jimhaseloff]

New: Associate Professor position in Synthetic Biology/Engineering Biology at the University of Cambridge. Looking for candidates with design-based bioengineering approach in plant biology.
(https://t.co/v1F7Egbn71)

[Martin Holub @martinxholub]

Travel tips for the UK? I have them now: https://t.co/Bttll9B5zz

[David R. Liu @davidrliu]

Three of the more costly and frequently used reagents in molecular biology are rolling circle amplification (RCA) mix, chemically competent MachOne (or other E. coli) cells, and Gibson assembly mix. Postdoc Julian Willis—who is starting his own lab in the UK soon—developed homemade recipes for each that reduce costs ~3x (or more at large-scale). Links to each recipe:

RCA mix:
https://t.co/Cmir57uM0J

Chemically competent MachOne cells:
https://t.co/kNYVxLIToA

Gibson assembly mix:
https://t.co/OFwXmmLDWB

[Martin Holub @martinxholub]

@caiyizhi @SBSatEd @UoMMIB It was quite inspiring to eavesdrop on this in the last meeting. Certainly a part of learning experience while I am with your lab. Thanks for sharing the memories, may you make many more in the coming decade :)

[Martin Holub @martinxholub]

@TismaMilos pretty good, whats the story of this making on a building facade?

[Martin Holub @martinxholub]

@DaisyPooler I am now in Manchester for three months! Let me know if you are nearby! :)

[Martin Holub @martinxholub]

Really excited for my stay with the lab of @caiyizhi at the @OfficialUoM 🥼🧪Big thanks to @EMBO for funding and to Patrick for hosting me 🙏

The first week is behind and what a blast! Everyone at @UoMMIB is super welcoming and helpful! And #Manchester is great as well 🐝

[Martin Holub @martinxholub]

@ClaudiaBonfio oh this is great! I think I will start stacking Vans to decorate :D Happy birthday!

[Martin Holub @martinxholub]

#labessentials

[Martin Holub @martinxholub]

@AptaWineClub oh this surprised even me :D well done!