Marvin Thielert

IMPRS PhD student at @labs_mann (@MPI_Biochem)

[Mariya Mardamshina M.D./Ph.D. @Mia_Mardamshin]

🔬Decoding Space at #ASMS2025
Join @marvinchth and me for a workshop on #multiplexed image analysis & #singlecell proteomics. Learn how to segment, explore, and transition from #highplex imaging to ultra-deep #MS profiling. Meet us today at the Bioinformatics Hub 12:30-2:30 pm!

[Matthias Mann Lab @labs_mann]

Nano-scale, mega-impact: nanoPhos delivers 100× phosphoproteomics sensitivity, 70k sites from 1µg, 8k from 10ng! Powered by SPEC, it enables phosphoDVP: deep spatial phosphoproteomics from 1000 neurons, hitting 17k sites, a game changer for spatial omics.
https://t.co/S9UdwkLh2x

[Matthias Mann Lab @labs_mann]

New approach tackles studying rare pediatric diseases! We developed an ontology-guided clustering framework using SNOMED CT to analyze proteomes from 1,140 children across 394 conditions - enabling meaningful insights even with tiny patient numbers!
https://t.co/Vn4Uq0DFL3

[Matthias Mann Lab @labs_mann]

Heading to #ASMS2025? Our team will be there showcasing our latest breakthroughs in mass spectrometry! Don't miss the chance to connect with @labs_mann team members and discover the cutting-edge work we have been developing.

[Marvin Thielert @marvinchth]

Happy to share our preprint in collaboration with the Lundberg Lab revealing spatial heterogeneity in human pancreatic islets with multiplexed Deep Visual Proteomics. Grateful for the fantastic team and collaboration!

[Matthias Mann Lab @labs_mann]

Excited to share our preprint on multiplexed DVP! mxDVP extends CODEX to DVP family, revealing spatial heterogeneity in human pancreatic islets with 12 endocrine sub-types including rare polyhormonal cells. Fantastic team effort @Prof_Lundberg #LundbergLab https://t.co/ZIT6dl2GjD

[Eric Topol @EricTopol]

The 2024 @naturemethods of the year
Spatial Proteomics
https://t.co/N4y9ZAzzZI
How It saved lives (Spatial Medicine)
https://t.co/yNW9FdnrFR

[Nature Methods @naturemethods]

The wait is over!! We are thrilled to announce that we have chosen Spatial Proteomics as 2024’s Method of the Year! 🥳

For more on Spatial Proteomics and a road map to this special issue, please see this month’s Editorial or read on in this thread.

https://t.co/phXooJzJda

[Eric Topol @EricTopol]

"A new standard for understanding disease progression
at the single-cell level in human tissue."
Unraveling liver disease in Alpha1-antitrypsin deficiency with #DeepVisualProteomics. Another major step forward with spatial omics and #AI.
https://t.co/9werKZQBle @labs_mann @metaboflo
Explainer thread https://t.co/QModB8ZgGH

[Georg Wallmann @GeorgWa]

We just release alphaDIA 1.8.2 including some new step-by-step guides for #Proteomics.

Learn how to:
• Run DIA searches from the GUI
• Create custom PTM models with DIA transfer learning
• Evaluate model performance with detailed metrics

https://t.co/R99QYxLDRe
#TeamMasSpec

[Matthias Mann Lab @labs_mann]

AATD affects thousands, causing liver & lung disease via protein aggregation. Our new preprint used #DeepVisualProteomics to study liver cells and reveals key AATD insights with clinical implications . Video and tweetorial @metaboflo #Alpha1Awareness
https://t.co/81egcO73Sv

[Matthias Mann Lab @labs_mann]

Check out the excellent ’Dawn of spatial medicine’ blog of Eric Topol where he describes our TEN DVP paper from last week.

[Thierry Nordmann @NordmannThierry]

Published today! Spatial proteomics reveals JAK/STAT as a target for Toxic Epidermal Necrolysis, an often fatal skin reaction to common medication. We validated our findings in pre-clinical models & successfully treated the first patients worldwide.🧵⬇️ https://t.co/JLHOSf6IAv

[Matthias Mann Lab @labs_mann]

Can a deadly rash be cured by repurposing drugs? Our @Nature paper says yes! Deep Visual Proteomics reveals JAK inhibitors as potential TEN treatment. A game-changer in #dermatology & #SpatialProteomics.
Congratulations to all!
@NordmannThierry's tweetorial explains below:

[Max Planck Institute of Biochemistry (MPIB) @MPI_Biochem]

Congratulations to Matthias Mann who receives the prestigious #HeinekenPrize for Biochemistry and Biophysics with Ruedi Aebersold for ‘revolutionizing the way proteins are studied’.

❕https://t.co/baJ0FPahoi
❕https://t.co/VK5rMse54q

@labs_mann #proteomics

[Matthias Mann Lab @labs_mann]

Missed the Thermo User meeting at on Sunday on the new targeted MS? Our preprint on the Stellar MS shows how to use it in combination with the Orbitrap Astral and Evosep One to design 15N labeled protein based assays. Check out Maria Wahle’s poster ThP733
https://t.co/Ng3fbtA1J7

[Marvin Thielert @marvinchth]

Check out the first version of alphaDIA! A modular open-source search framework for DIA data with end-to-end transfer learning. Great work from @GeorgWa and team effort of @labs_mann

[Matthias Mann Lab @labs_mann]

1/7 @labs_mann and Georg Wallmann @GeorgWa are proud to announce alphaDIA, our open source, next generation DIA search engine. Check out the preprint @biorxivpreprint

https://t.co/2HuOd1AJMy

[Lisa Schweizer @LisaCSchweizer]

I am proud to announce that I successfully defended my PhD today. Thank you very much to @labs_mann @MPI_Biochem and @OvCa_UChicago for this unique journey!

[Sophia Mädler @SophiaMaedler]

I'll be presenting ✨SPARCS✨ our recently developed platform for microscopy-based genetic screens at genome scale in a webinar organised bei @LeicaMicro and @BitesizeBio soon! 🚀👩‍💻

Check out the details and register here: https://t.co/ggAi8DKiey

[Matthias Mann Lab @labs_mann]

Thanks to @MichaelJFoxOrg for hosting the Bio-Hackathon, where @labs_mann represented by Matthias Mann and @OellerMarc, together with four other expert teams collaborated to investigate alpha-synuclein modifications in Parkinson's disease.
https://t.co/TLHFHZyLWq

[Marvin Thielert @marvinchth]

It has been a great conference #HUPO2023, catching up with many and making new connections in Busan.
I was honored to give a talk and finish as a runner up in the 3 minute thesis competition (3MT).
Thank you to the organizers of HUPO and #ECR.

[Matthias Mann Lab @labs_mann]

Congrats to Johannes @JoBMller for winning the HUPO manuscript competition and a big shout out to Marvin @marvinchth for the runner up finish in the 3 min thesis competition! Well done!