We are sad to share news of Jean Futrell's passing. He was a GIANT of mass spec and a MIGHTY advocate & supporter of @asmsnews. Our thoughts are with Jean's family, friends, and colleagues.
Learn more about Jean:
https://t.co/N9nqk5rTQ0
https://t.co/E4ZPIBJuyS
#TeamMassSpec
[ASAP] Hybrid Quadrupole Mass Filter–Radial Ejection Linear Ion Trap and Intelligent Data Acquisition Enable Highly Multiplex Targeted Proteomics https://t.co/JydxDtGTbk
Comet's open-source search engine has been a boon for our proteomics methods developments (like real-time search). Over the last two-years we became curious whether Comet's search speeds could be improved to keep pace with modern instruments and large sample cohorts.
@Popher It can definitely be useful in combination with msn for unequivocally stringing together fragmentation paths (e.g. A+ -> B+ -> C+), especially when combined with hram. It’s one of the (many) things I love about tribrids.
@Popher I think the main practical difference is that you don’t get much sequential fragmentation with “cid” in traps on thermo instruments, because the excitation waveform is only exciting the precursor mz.
@Popher I’m assuming it’s regulated the same as San Jose instruments, and the ‘units’ is just psi. If it can’t get up to a number that it used to before, there’s probably a leak (e.g. if the source hosting isn’t sealed to the instrument well).