masterodst1

[SciTech Era @SciTechera]

BREAKTHROUGH:

I think Al is now the most powerful tool ever created for accelerating biological discovery..

"Researchers just used AlphaFold3 AI to redesign CRISPR proteins, making gene editing dramatically more precise by reducing harmful off-target DNA edits."

"The team developed an AI-guided framework called ContactSeek, which identified the exact amino acids in Cas9 responsible for binding mismatched DNA sequences."

"By engineering just 23 targeted amino acid substitutions across 10 key positions, they created a redesigned Cas9 variant that reduced off-target editing from 28% to 5% while maintaining strong on-target activity."

"The approach also successfully generalized to Cas12a-based cytosine base editors, suggesting it could become a universal strategy for designing safer genome-editing systems."

AI is now helping scientists engineer safer molecular machines, bringing us closer to precise gene therapies for inherited diseases, cancer, and many other genetic disorders.

[Georgian Avasilcutei @nimlot26]

Time to show off the rabbit hole I've went down for the last few weeks. Here's the sweat shader driven by a niagara simulation that I've made in UE5.

[Javi Lopez ⛩️ @javilopen]

THIS IS CRAZY 🤯Bifrost just shipped a proper real2sim pipeline that actually works at production speed!

You send a single video of a real industrial site or lab. Their system reconstructs a fully navigable, photorealistic 3D environment in ~30 minutes instead of the usual 12+ hours of manual modeling.

Technical stack under the hood:

- 3D Gaussian Splatting (and derivatives like World Labs Marble) turns the video frames into a dense, view-dependent radiance field. This gives real-time rendering of the exact geometry, materials, and lighting of the captured space without traditional mesh reconstruction bottlenecks.

- Articulated asset generation (building on models like TRELLIS for static objects and Articraft-style systems for movable parts) automatically extracts and converts objects into simulation-ready rigid-body or articulated assets with correct collision geometry, joints, and physical properties.

- GPU orchestration + domain randomization layers on top so the environment can be relit (GaRe-style), cluttered, and sensor-simulated across RGB, depth, segmentation, and 6-DoF poses.

The result is a high-fidelity digital twin that robots can interact with immediately. You drop your policy into the reconstructed scene, run thousands of parallel rollouts on Manifold, and surface failure modes at compute speed rather than waiting for real-world iterations.

This closes a big part of the classic sim-to-real gap: visual fidelity no longer looks like a 2001 PS1 game, and the physics/assets are grounded in the actual site instead of generic asset libraries.

The DeLorean garage demo is just the public teaser: the same pipeline is already being used for factory cells, warehouses, and manipulation benchmarks.

[80 LEVEL @80Level]

Get a massive collection of over 370 8K scanned materials from @ScansMatter, ready to use in Unreal Engine projects.

[Om Patel @om_patel5]

THIS GUY VIBE CODED AN AR APP THAT LETS YOU PHYSICALLY SEE THE WIFI SIGNAL IN THE AIR AROUND YOUR HOUSE

wifi is completely invisible, so when your connection is bad you just guess. move the router, move your desk, hope

but this makes the signal visible through your camera

> hold your phone up and the signal strength floats in the air as colored orbs, green where its strong, yellow and purple where its dropping off
> walk around and it paints a live heatmap across your actual floor, so you literally see the signal fade room to room
> run a real speed test from wherever youre standing, down, up and ping, pinned to that exact spot
> it flags dead zones with a no entry marker so you know where not to put your desk
> pick your visualization, lava, gauge or balls, and switch between peak and average signal
> import your floorplan and save your heatmaps to compare before and after moving the router
> it also scans every network around you, 55 found in this one, plus channel congestion so you know which channel to switch to

everyone with wifi has this problem and nobody had a way to see it. now we do

[Brad Lynch @SadlyItsBradley]

UEVR + Halo Campaign Evolved + Third Person Perspective Skull…

Absolutely awesome. I feel like I’m over indulging myself on Halo this week though 😂

[Ihtesham Ali @ihteshamali]

BBC literally built the greatest sound library on the internet.

It is called BBC Sound Effects, and it gives you access to more than 30,000 recordings from around the world.

Just search any word, and it instantly finds matching sounds.

You can filter them by category, duration, and even the continent where the sound was recorded.

Every sound can be previewed inside your browser, downloaded, or added to the built-in mixer so you can layer multiple recordings together.

And the archive gets insanely specific.

You can find creaking ships, old typewriters, jungle ambience, distant church congregations, and even someone vigorously washing their hands.

There is a good chance a BBC engineer recorded the exact sound you need decades before you were born.

https://t.co/vdOBewxyg3

[SciTech Era @SciTechera]

This is huge. Scientists Just Broke an 80-Year Rule of Aerodynamics With Microscopic Roughness. 👀

"Researchers at Tohoku University developed a Distributed Micro-Roughness (DMR) surface that reduced aerodynamic drag by up to 43.6%, despite using microscopic roughness instead of a perfectly smooth surface."

"Team found that the microscale roughness appears to suppress Tollmien-Schlichting (T-S) instability waves, delaying the transition from laminar to turbulent flow and reducing skin-friction drag."

"Results were also validated using a Magnetic Suspension and Balance System (MSBS), wall-resolved Large Eddy Simulations (LES), and dynamic oil-flow visualization.

This suggests us carefully that engineered microscopic textures could improve the efficiency of future aircraft, cars, ships, and high-speed trains.

[さらさら @sarasara_aiart]

長押しで変化？ 𓂃𓈒໒꒱ 𓏸*˚

[Synth Potato🥔 @SynthPotato]

Starfield modders have managed to entirely remove loading screens when taking off from planets, addressing the interruption in gameplay and boosting immersion massively.

Author 0xBobby plans to make it even more seamless in the future with updates!

[SciTech Era @SciTechera]

Another mathematical breakthrough

GPT-5.5 just helped discover new mathematics, not just solve it 🤯!

Researchers have shown that GPT-5.5 can contribute to original mathematical research in Banach Space Theory, one of the most abstract branches of pure functional analysis, instead of only solving existing benchmark problems.

In the study, AI generated the key ideas and proof strategies for five new mathematical results. Instead of solving existing benchmark problems, AI collaborated with mathematicians to tackle open research questions.

After that every proof was then rigorously verified and refined by human experts mathematicians.

The team also built an AI-powered mathematical discovery pipeline that searches research literature, identifies open problems, and generates candidate proofs.

This is a future where AI accelerates mathematical discovery itself as well.

[XBOX @XBOX]

Introducing XBOX Backward Compatibility on PC 🎮🖥️

Play four original XBOX titles across supported PCs and handhelds today, with more on the way: https://t.co/WpcbOOxzlc

[Unity @unity]

Introducing Unity 7 - built for a faster-moving, more open industry where creators, cross-functional teams, and coding agents can seamlessly collaborate across every stage of the development cycle. Featuring:

- Create faster: Modernized CoreCLR foundation with a near-instant Play Mode and up to 90% faster shader builds.
- Collaborate in better ways: New CLI, public API, and free MCP connect teams and coding agents directly to Unity.
- Ship sharper graphics: Richer, realistic lighting via Surface Cache GI across all Unity supported devices.
- Grow and monetize smarter: Built-in Unity Vector tools, native webshops, and direct-to-consumer IAP to scale efficiently.
- No breaking changes: A direct continuation of Unity 6 architecture, offering an upgrade path with zero rebuilding.

Unity 7 will enter early Beta testing in December, with the Full Release scheduled for Q1 2027.

[masterodst1 @masterodst11]

@THEFATROD @FaresAlHaqbani https://t.co/rraH07OhqA

[SciTech Era @SciTechera]

🚨 China has successfully completed the world's first implantation of a commercially approved invasive brain-computer interface (BCI).

New device, called NEO, became the first invasive brain implant to receive commercial approval from China's NMPA in March 2026.

The first recipient was a patient who suffered a spinal cord injury in a car accident about 10 years ago, leaving them with severely impaired hand movement.

The coin-sized NEO implant contains 8 recording electrodes that sit on the brain's dura mater (the protective membrane covering the brain), where they record neural signals generated when the patient intends to move.

AI decodes these brain signals in real time and converts them into digital commands that control a robotic rehabilitation glove, allowing the patient to perform hand movements without relying on damaged spinal nerves.

Unlike many experimental BCIs that remain in clinical trials, NEO has already received regulatory approval for commercial medical use.

[SciTech Era @SciTechera]

BIG ANTI-AGING BREAKTHROUGH

Scientists just reverse a key form of aging damage once thought permanent 🤯!

> Researchers engineered a novel enzyme called CMLase that repairs Advanced Glycation End Products (AGEs), harmful molecular damage that builds up in tissues as we age.

> In aged human artery tissue, the enzyme removed over 70% of accumulated CML damage. In elderly human skin, it reduced CML levels to those seen in approximately 30-year old skin.

> AGEs stiffen arteries, weaken skin, and damage the extracellular matrix (ECM), the structural scaffold that supports our cells. They were long considered irreversible.

> This is the first evidence that a major AGE can be enzymatically repaired in human tissue, opening a new path toward structural rejuvenation alongside cellular anti-aging therapies.

welcome to the fastest accelerating SciTech Era ♥️ 🫡!

[SARS‑CoV‑2 (COVID-19) @COVID19_disease]

🚨 BREAKTHROUGH: Scientists at the University of Nottingham have developed a new enamel-repairing gel that starts restoring teeth in just 2 WEEKS.

This could replace fillings and change dental treatment worldwide, with use expected around 2026–2027.

[masterodst1 @masterodst11]

@bradenbecker @JEST0Z @NitroSpidey The problem i think is he applied it too broadly as a filter to the whole image instead of just really affecting mid tones and shadows. Also the blue over powered the red. I think this is closer but im not a colorist.

[Bernt Bornich @BerntBornich]

NEO's finally learning sign language

[Bernt Bornich @BerntBornich]

Introducing NEO’s 25 Degrees of Freedom, tendon-driven hands — nearing or surpassing human-level dexterity, strength, speed, and reliability.

For seventy years, robotics worked around the hand problem. The humanoid bet is the reverse: it lives or dies at the fingertips.