AA

Material realist trying to be a grown-up in room. As pro nouns as I am verbs and adjectives.

[AA @materialsister]

@Transgendertrd So we find out criteria for inclusion in HoL not in the protocol, not at ethics approval.stage. This is insane

[AA @materialsister]

@LeorSapir So what's the point of the trial then, if they know this already?

[AA @materialsister]

@RosieDuffield1 @sharrond62 @BBCWomansHour Its so disrespectful@bbcwomanshour

[AA @materialsister]

@VincentPsychSE @WPA_Psychiatry Can you follow me pls?

[AA @materialsister]

@AGallagherAlly Naked? In the workplace? Where do you work?

[AA @materialsister]

@NeuroSGS Iq differences and how they relate, or not, to brain differences?

[AA @materialsister]

@SatpathyOnTruth @CarnegieMellon Is there some kind of standard of how many responses you get before someone points out this a parody account?

[AA @materialsister]

@DAaronovitch @JoolsJuevans Classy

[AA @materialsister]

@HPluckrose I read cynical theories recently and finally understand the madness around us. Its a brilliant book, and often very funny. Please thank her

[AA @materialsister]

@dilanesper I find it offensive and insulting. You can believe me or not, you have a right to believe what you want

[AA @materialsister]

@ScotRamsay @HooverMouse @ProfLAppleby @metpoliceuk There was nothing criminal in the original report. The police are meant to check that first.

[AA @materialsister]

@ScotRamsay @ProfLAppleby @metpoliceuk Apart from asking him not to contact Arday. So not to carry on doing his job..

[AA @materialsister]

@witch_worst @sheebadigeebies @Sorelle_Arduino Its just astonishing this hasn't happened.

[AA @materialsister]

@sheebadigeebies @witch_worst @Sorelle_Arduino Quite. But they still could retrospectively. Its shameful not to have tried

[AA @materialsister]

@witch_worst @sheebadigeebies @Sorelle_Arduino It certainly wasn't an ethically approved or properly designed one but they have given these drugs to kids. I just think there's a duty to try to find out what happened to them

[AA @materialsister]

@sheebadigeebies @witch_worst @Sorelle_Arduino You may be right which is scandalous in itself but there are morbidity and mortality stats. Bone density could be compared to population norms.

[AA @materialsister]

@sheebadigeebies @Sorelle_Arduino The effects of the drugs are known in other populations already (and that's bad enough but at least in prostate ca it's scientifically and ethically justified) but this is a novel indication

[AA @materialsister]

@sheebadigeebies @Sorelle_Arduino But that mainly relies on clinician redcards and then the MHRA alert us. If the purpose is to block puberty with its known effects of doing that the system wouldn't pick it up. The manufacturers would surely say the drugs are offlicense so not their job

[AA @materialsister]

@sheebadigeebies @Sorelle_Arduino Using a drug off license is common in paeds but if its being used for a novel research indication- such as GD- it should be piloted first. I don't know what PV means but its unknown because noone has done the data linkage study if it showed harm the trial couldn't go ahead

[AA @materialsister]

@sheebadigeebies @Sorelle_Arduino Not for an RCT. First step is to pilot the intervention. If animal studies for example demonstrate signals the next step is a feasibility pilot of safety, feasibility and acceptability. A real world pilot has happened so that data needs linking