Matteo Bologna

[Luca Marsili, MD @LucaMarsili1]

What happens when PD meets myasthenia gravis?
Patients with PD+MG reach key postural and cognitive milestones earlier than PD-only patients.
🧠 @PecoraroPasquale @AlbertoEspay @heba_deraz @UCMovDis
#MovementDisorders
https://t.co/tBxcAFvKas

[Movement Disorders Journal @MDJ_Journal]

Insightful article by Paparella and colleagues exploring the Bradykinesia complex (bradykinesia+ hypokinesia+ dysrhythmia+ sequence effect) in Parkinson's disease. @AlbertoEspay @DrAlfonsoFasano https://t.co/690cU0h5nu

[UC Movement disorders @UCMovDis]

Teaching case: Cerebellar ataxia and Hypomyelinating Leukodystrophy in POLR3B variant seen in our neurogenetics clinic.

Link: https://t.co/6tC8RGLeFu

[Roberto Cilia @CiliaRoberto]

@MassiPassaretti @MatteoBologn @APStrafella Find out neurophysiological mechanisms of motor compensation in early Parkinson’s disease including a novel Motor Compensation Coefficient @MassiPassaretti @MatteoBologna @APStrafella

[Massimiliano Passaretti @MassiPassaretti]

Finally out our work on motor compensation in early PD. Great effort of all co-authours @CiliaRoberto @MatteoBologn @APStrafella

[UC Movement disorders @UCMovDis]

What is the whistle-smile reflex in Parkinson’s disease?

Our faculty @LucaMarsili1 and @AlbertoEspay investigate in this study led by @MatteoBologn in @MDCP_Journal

https://t.co/CjSUnD0oYC

[Michael Okun @MichaelOkun]

Can you pick out who has Parkinson's disease from the video using the 'whistle-smile' reflex? Maybe? Frederic Hanes described this sign in 1943. Giulia Paparella and colleagues revisit the observation in a trial of 34 Parkinson's folks versus 34 healthy controls in @MDCP_Journal.
Key Points:
- When healthy individuals are prompted to whistle during a medical examination, 'they typically comply and subsequently smile.'
- In Parkinson's 'they execute the whistle but often fail to produce an immediate smile.'
- In their study they showed a sensitivity of 76% and a specificity of 65% for the sign.
My take: It is hard to believe that there are only two papers on this sign published since 1943. Behavioral neurologists have long been fascinated by spontaneous smiling versus posed and elicited smiling in Parkinson's disease. Though the sensitivity and specificity are too low to become a biomarker, this is a sign neurologists can keep in their pockets for teaching. Researchers may also consider studying this phenomenon with functional imaging as the limbic-motor newtowrk is fascinating and we have also observed DBS induced smiling. The brain is a fascinating supercomputer and frankly, we do not know what we do not know. Ecce signum – behold the sign of the smile in Parkinson's.
https://t.co/GGzIlRgM4T #Parkinsons
Smiles induced by DBS:
https://t.co/SC2cO5lmBj
Spontaneous and posed smiles in Parkinson:
https://t.co/2RgLs5oc63
Motor cortex and facial smiling in primates by Morecraft:
https://t.co/vSzGLsz9pc #Parkinsons #smilefest2024 #smile

[The Science of Parkinson's @ScienceofPD]

New research from @MatteoBologn & colleagues involved the recruitment of 34 people with #Parkinsons & 34 control volunteers, & then asking them to 'whistle' during assessment

The Hanes sign (“whistle-smile” reflex) could hold potential in PD assessments
https://t.co/hQuqC8DszJ

[Abhimanyu Mahajan @AMahajanMD]

Happy @UCMovDis fellowship graduation!

Congratulations Dr. Lin @miniowlcat and Dr. Marsili @LucaMarsili1!

Dr. Lin will join @TriHealth as a movement disorders neurologist

Dr. Marsili will join @uofcincy as faculty.

[Lucia Ricciardi @LuciaRicciard10]

Our chapter on functional dystonia is online.
Congratulations @AnnaSadnicka and @Shaikh_Lab for the great book.
Thanks to the wonderful team @AlbertoEspay @LucaMarsili1 @MatteoBologn !

[Abhimanyu Mahajan @AMahajanMD]

Diagnostic uncertainties in Tremor

Drs. @LucaMarsili1 @MatteoBologn and I discuss our clinical approach, etiological differential and associated diagnostic challenges in patients presenting with tremor

Link: https://t.co/Cu7jBEn7oY

@SeminNeurol #NeuroTwitter #Neurology

[Alfonso Fasano @DrAlfonsoFasano]

in the great company of @MatteoBologn, @AlbertoEspay, @MarkHallett007 et al to (re)define #bradykinesia.

The more you study something the less you understand it.

@MDJ_Journal @KBI_UHN @UHNSHSNeurology
https://t.co/rLAGfqJocr

[Brain @Brain1878]

#Bradykinesia is one of the cardinal motor symptoms of #Parkinson’s disease, but its mechanisms are not fully understood. Bologna et al. review recent findings on bradykinesia pathophysiology, including the role of network dysfunction. https://t.co/zDnWM3WBp6

[IAPRD @PRDAssociation]

Join #IAPRD2021 to hear Dr. Albert Espay discuss Parkinson’s and related syndromes: Time to reject the Braak hypothesis. See (https://t.co/o2yOcuqyc8) our full scientific program and register (https://t.co/qD1HwWnJH6) today.
#Parkinsonsdisease #Parkinsons

[IAPRD @PRDAssociation]

Read the new review in #PRDjournal on https://t.co/f9ukCFlg9Y by Marsili and colleagues.
#Parkinsonsdisease #Parkisnons

[IAPRD @PRDAssociation]

Don’t miss the Pathophysiology of Parkinsonian Syndromes session #IAPRD2021 chaired by Drs. Etienne Hirsch and Erik Wolters.
https://t.co/ZcMCu7ACGj

[IAPRD @PRDAssociation]

Get the latest on Biomarkers in Parkinsonism and Related Disorders from Drs. Wilma van de Berg, Pascal Derkinderen, and Ken Marek #IAPRD2021. See our full full scientific program for more great talks. https://t.co/EqvpWwkeke

[IAPRD @PRDAssociation]

The IAPRD salutes all those living with and working to end Parkinson’s disease.
#parkinsonsawarenessmonth #tremors #parkinsonsresearch #parkinsonsfoundation

[Alberto J Espay @AlbertoEspay]

The nearly two-decade-old Braak hypothesis has survived overwhelming evidence to the contrary.

Tune in to "Time to Reject the Braak Hypothesis" on Saturday, May 1, at the Virtual IAPRD 2021 Congress (15:00 CET)

https://t.co/KbLHMXpZYo