Ketamine Reduces “Giving Up” by Targeting Brain Support Cells
Researchers discovered that ketamine reduces stress-driven "giving up" behavior by targeting astroglia, brain support cells, rather than neurons.
Using zebrafish, scientists observed that ketamine overstimulated astroglia, which reduced their sensitivity to stress signals, enabling the fish to persist longer in challenging situations.
Whole-brain imaging revealed prolonged activation of astroglia following ketamine exposure, explaining its lasting antidepressant effects.
Similar mechanisms were confirmed in mice, suggesting the findings could translate to humans.
The study challenges the conventional focus on neurons in depression research and highlights astroglia as key players in mood regulation.
This breakthrough could inspire the development of new antidepressants targeting astroglial cells.
"If you wanna go fast, go alone. But if you wanna go far, go together."
“ถ้าอยากไปเร็ว ไปคนเดียวได้ แต่ถ้าอยากไปไกล ให้ไปด้วยกัน”
จริงมาก โดยเฉพาะเวลาเรามีทีมที่ดี แล้วทำเรื่องใหญ่ๆ ด้วยกัน ..
"If you wanna go fast, go alone. But if you wanna go farther, go together."
“ถ้าอยากไปเร็ว ไปคนเดียวได้ แต่ถ้าอยากไปไกล ให้ไปด้วยกัน”
น่าคิด.. แล้วทุกคนกำลังไปแบบไหนอยู่?
#team#ผู้นำ#หัวหน้า