Liam McNamara ⁂

Founder @matrixbiotech, Z Fellow, 🇨🇦🇺🇸

[Samuel Hume @DrSamuelBHume]

One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results

I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore

[Liam McNamara ⁂ @mc_liamm]

@therealcanadawy @eshanbetrabet 2/10 ragebait

[Zane Koch @zanehkoch]

ok actually insane paper published yesterday

a research group in Korea built a gene switch you can control wirelessly using electromagnetic fields

they exposed mice to 60 hz EMF (same frequency as your wall outlet) using a pair of large coils that generate a uniform magnetic field around the animal, for cyclic 3-day on / 4-day off pulses

they showed this could:
- activate OSK to do epigenetic reprogramming in progeroid and aged mice, extending lifespan and reversing aging markers across multiple tissues
- conditionally switch on mutant amyloid genes only in aged mouse brains, letting them separate aging effects from amyloid effects to study AD biology in a way previous models couldn't

no drugs, no impacts, just a magnetic field from outside the body

[nature @Nature]

For decades, researchers have noted that cancer and Alzheimer’s disease are rarely found in the same person

https://t.co/rgYalgRdfi

[robin @zebird0]

On the road to being great don’t forget to be good

[Liam McNamara ⁂ @mc_liamm]

@Mankaran32 @niccruzpatane It takes a significant amount of time for tech to permeate through society, if FSD was solved tomorrow roads wouldn’t be majority autonomous for years. Same with LLMs, most people in the US are ignorant to advances in AI

[Liam McNamara ⁂ @mc_liamm]

Peaked 1650 rapid @foundersfund

[hinata @HinataMotivates]

Magnus Carlsen: Hedge funds are actively recruiting chess players.

[delian @zebulgar]

This is probably my favorite graph

If you look at the complexity of genomes on Earth over time, there's a linear relationship between genomic complexity & when it shows up in fossils

Yet if you go back it implies Earth did not start life from scratch, e.g. an asteroid seeded it

[Peter Tulip @peter_tulip]

"In medical research, there’s a practice of ending a study early when the results are too striking to ignore. ... When an intervention works this clearly, you change what you do."

[Liam McNamara ⁂ @mc_liamm]

@alspee @cladoai @davidbshan

[Liam McNamara ⁂ @mc_liamm]

@HamzakAmmar Ask Moulik

[Liam McNamara ⁂ @mc_liamm]

(Using the Russell 3000 as a proxy for changes in the value of all publicly traded stocks)

[Liam McNamara ⁂ @mc_liamm]

In 1975, the money supply in the US was $1.47 trillion. The total value of the US stock market was $1.11 trillion, making the stock-to-dollar ratio ~ 0.75.

At the peak of the dot-com bubble, this ratio was 2.91. When markets recovered in 2015, it was 1.65.

Now we're at 3.07.

[Liam McNamara ⁂ @mc_liamm]

@sighjith Very cool! Would love it if this could:
- Act like a citation web like @BenchSci
- Bookmarks tab
- Algorithmic paper feed?

[Liam McNamara ⁂ @mc_liamm]

>raise pre-seed round for company
>call family, excited to be a founder
>”this will look great on your med app”

[Liam McNamara ⁂ @mc_liamm]

Knowing how to cold email is the best vehicle for upward mobility as a young person. It got me from virtually nothing to a dream lab internship and pre-seed funding in less than 10 months.

Shout out @krish_mendapara for teaching me

[Krish Shah @KrishRShah]

In my earlier years I A/B tested different subject lines for cold emails to get internships.

Was probably one of the most valuable experiments I ever ran. Still pays dividends.

Thank you to all that took the time to reply 🫶