Excited to share the latest addition preprint from the @KozlowskiMarisa lab. We report on a photochemical heteroarylation of phenols guided by substrate clustering, HTE, and machine learning. @KalyanaDuggal@PennChemistry@ChemRxiv https://t.co/2RyBlW2O23
Congratulations to Matt (@mccarson23) on getting the 2026 John G. Miller Award for Most Outstanding Doctoral Thesis in the Department of Chemistry! @PennChemistry
Excited to share the latest addition preprint from the @KozlowskiMarisa lab. We report on a photochemical heteroarylation of phenols guided by substrate clustering, HTE, and machine learning. @KalyanaDuggal@PennChemistry@ChemRxiv https://t.co/2RyBlW2O23
Dotinurad: a ‘Next-Gen’ Uricosuric Looking to Crack the US Gout Market | https://t.co/v7Dogl5l3T
Dotinurad (FYU-981) is a URAT1 inhibitor approved for gout/hyperuricemia in Japan and China (Urece®) and is now in late-stage development in the US.
By blocking renal proximal-tubule uric acid reabsorption, dotinurad increases urinary urate excretion and lowers serum urate, the key biochemical driver of gout.
The molecule was optimized from the historical uricosuric benzbromarone in an effort to retain urate-lowering efficacy while reducing instances of rare but serious hepatotoxicity.
Building on its clinical experience overseas, Crystalys has initiated two Ph. 3 trials benchmarking dotinurad against first-line gout treatment allopurinol, with primary completion expected in late 2027.
Read more on Drug Hunter: https://t.co/v7Dogl5l3T
It's no secret Justin Allen has been a difference-maker for @gbphoenixmbb all season long, and what happened to him two weeks ago in Pittsburgh speaks volumes to who he is as a person:
"That meant everything to me, that was the coolest experience of my life." @Justin_Allen14
Excited to share the latest addition preprint from the @KozlowskiMarisa lab. We report on a photochemical heteroarylation of phenols guided by substrate clustering, HTE, and machine learning. @KalyanaDuggal@PennChemistry@ChemRxiv https://t.co/2RyBlW2O23
@mccarson23 giving a talk at Pacifichem this past week in Honolulu, HI on the final project from his PhD!
🔗 Link to the ChemRxiv preprint:
https://t.co/fJo87FvIoh