Medchem toolbox

RT your synthetic work @mchem_toolbox if its operationally simple, broad, produces new/privileged cores. @[email protected] | Run by @SaayakH

[Medchem toolbox @mchem_toolbox]

Synthetic medchem is heavily skewed with only a handful of reactions (ex. amidation) used towards making new molecules, mainly due to simplicity and ease of the reaction. New developments in synthetic chem is still under-used in the medchem community. This page will try to

[Medchem toolbox @mchem_toolbox]

Wanna make C-N bonds? Check out this work on Pd cat. oxidative amination of unactivated alkenes. @J_A_C_S #medchem_toolbox
https://t.co/NHNMnIV56s

[Medchem toolbox @mchem_toolbox]

Check out this work on addition of BrCN onto alkenes; the intermediate can be useful for diversity oriented synthesis! Cool work @JOC_OL @knskkykw
https://t.co/iWOhXFHxSR

[Medchem toolbox @mchem_toolbox]

Check out this work. #Synthetic_Chem empowering #medchem

[MacMillan Group @MacMillan_Lab]

Collaborating with @pfizer, we bring traditional med chem discovery into 3D, showcasing the power of iterative photoredox transformations to rapidly build sp3-rich drug cores. Congrats to @DavidFer_Gz, @magones83, and the whole team! https://t.co/EaGPUrDVAa

[J. Am. Chem. Soc. @J_A_C_S]

Room-Temperature Cu-Catalyzed Amination of Aryl Bromides Enabled by DFT-Guided Ligand Design @MIT @MITChemistry @BuchwildGroup
@TotalSyntheses #RT #CuCatalyzed #Amination #ArylBromides #DFTGuided #Ligand #Design https://t.co/qz1cbtDHuS

[Margaret Brimble @BrimbleM]

The mother of trofinetide is so happy and proud! @AucklandUni @MWC_CoRE @SCSatUoA

[Medchem toolbox @mchem_toolbox]

With growing availability of chiral boronic acid building blocks, this work can be impactful towards chiral medchem libraries! @J_A_C_S
Stereospecific Acylative Suzuki–Miyaura Cross-Coupling: General Access to Optically Active α-Aryl Carbonyl Compounds https://t.co/57vyMUkFWm

[Medchem toolbox @mchem_toolbox]

Checkout this work on Visible-Light-Driven Hydroacylation of Unactivated Alkenes https://t.co/gP95vf0wQW #syntheticmedchem #feedly

[Medchem toolbox @mchem_toolbox]

Using air sensitive organometallic reagents require special handling/training, limiting it’s use and reliability. Check out this work- authors prepared air stable gels impregnated with RLi reagent-this can be the future! ⁦⁦⁦@ChemistryatYork⁩ https://t.co/ojCPhmfMEY

[Medchem toolbox @mchem_toolbox]

Making unnatural amino acids is still tedious and lacks generality. Check out this work on-
Towards Enantiomerically Pure Unnatural α-Amino Acids via Photoredox Catalytic 1,4-Additions to a Chiral Dehydroalanine https://t.co/Iw4aD5tTpE
Cool work @JOC_OL @hebusto

[Medchem toolbox @mchem_toolbox]

Check out this TM free work on transforming unactivated alkenes into ab-unsaturated carbonyls. Cool work! @angew_chem @SoosGroup

[Angewandte Chemie @angew_chem]

Intertwining Olefin Thianthrenation with Kornblum/Ganem Oxidations: Ene-type Oxidation to Furnish alpha,beta-Unsaturated Carbonyls (Soos) @SoosGroup #openaccess https://t.co/1MVdWrXDPO

[J. Am. Chem. Soc. @J_A_C_S]

✨One of Our Most Read Papers in Past 12 Months✨
"The Open Reaction Database" by @StevenKearnes @cwcoley & colleagues
Read it here 👉 https://t.co/nkabJIoV6W

[Medchem toolbox @mchem_toolbox]

Want to make (gem)-difluoro substituents? Check out this work @CommsChem . Hope to see this reagent available commercially someday!
https://t.co/4ZWdhsUWur
https://t.co/sZU2dzbQ1I

[Medchem toolbox @mchem_toolbox]

"There is no one-size-fits-all fluorophore"-- well said!
A cool read if you wanna learn about fluorophores in chemistry and biology. @naturemethods @rhodamine110 @jonathangrimm

[Nature Methods @naturemethods]

Are you curious about using organic dyes in your microscopy experiments but not sure where to start? This Perspective from @rhodamine110 and @jonathangrimm introduces readers to the world of dyes and their pros and cons for biological applications. https://t.co/3Vm8SWB7Yz

[Medchem toolbox @mchem_toolbox]

A review from 2021 @jenn_prescher @ACSChemRev, Bioorthogonal Reactions never get old though! A great and informative read! https://t.co/XPs1hopSJl

[Angewandte Chemie @angew_chem]

Deaminative Arylation and Alkenyaltion of Aliphatic Tertiary Amines with Ary and Alkenylboronic Acids via Nitrogen Ylides (Song) https://t.co/07nt9SinUy

[Boron-Chem-Research @Boron_Chemistry]

Ligand-enabled C–H borylation of diverse classes of arenes (@TetrahedronChem): https://t.co/ypkwiyZgGz.

[Boron-Chem-Research @Boron_Chemistry]

Metal-Free Catalytic Hydroboration of Unsaturated Compounds: A Greener Strategy for the Synthesis of Organoboranes (@ChemCatChem): https://t.co/eYC4rb5XeE (@amritadas17, @TarunPanda2016).

[Medchem toolbox @mchem_toolbox]

And older paper, but informative!

https://t.co/EPCynyVZCd

[Yulab @YulabJin]

Explore the universe of Lactone scaffold as potential pioneers for drug molecules: accessing various ring size, topology by different C-H activation reactions. Our seventh reaction for lactones just appeared in JACS ASAP. The next one is even more surprising...

[Donohoe Group @DonohoeGroup]

You can read all about recent advances in the field of dearomative functionalisations of heteroarenes in our newest perspective, out now in @ChemicalScience!

Congratulations to @Dr_Nik_K and Bruno 🎉

https://t.co/YVmVFoMk2a