Kyle Medak

Post-Doc Mt Sinai LTRI

[Daniel J Drucker @DanielJDrucker]

Weight loss produces many cardiometabolic benefits and is a key goal and feature of Rx with GLP-1 medicines. Here @MedakKyle highlights how semaglutide reduces blood pressure in mice through the vascular smooth muscle cell GLP-1 receptor @JCI_insight
https://t.co/SmazNdEPTd

[Daniel J Drucker @DanielJDrucker]

Weight loss produces many cardiometabolic benefits and is a key goal and feature of Rx with GLP-1 medicines. Here @MedakKyle highlights how semaglutide reduces blood pressure in mice through the vascular smooth muscle cell GLP-1 receptor @JCI_insight https://t.co/SmazNdEPTd

[JCI insight @JCI_insight]

Supporting the concept that #GLP1 agonist drugs lower #BloodPressure independent from their weight loss effects: https://t.co/bztTSq6NUR

Kyle D. Medak @MedakKyle Daniel J. Drucker @DanielJDrucker & team @SinaiHealth identify the vascular smooth muscle GLP-1 receptor as a key cellular target for the actions of GLP-1 medicines to lower blood pressure.

The figure: Renal GLP1R/Glp1r is expressed in human and murine vascular smooth
muscle cells (VSMCs) and Glp1rVSM-/- mice have reduced Glp1r transcripts in renal
tissues.

[JCI insight @JCI_insight]

@MedakKyle @DanielJDrucker @SinaiHealth Behind the scenes with first author Kyle Medak working at the bench and microscope.

[Daniel J Drucker @DanielJDrucker]

GLP-1 medicines have multiple direct and indirect effects that modify cardiovascular risk. Here Kyle Medak @SinaiHealth and colleagues identify an important role for the VSM GLP-1R in the reduction of blood pressure #hypertension @JCI_insight @uoftmedicine https://t.co/83Oyr1u7LM

[HHNS at UofG @UofG_HHNS]

🍾CONGRATULATIONS DR. PIGNANELLI!👍
📢Chris Pignanelli, PhD, Successfully Defended His Thesis!
🚴‍♂️Effects of Blood Flow Restriction During Exercise
🥼Prof. Jamie Burr's Lab @UofGResearch!
🏃Human Performance Lab: https://t.co/ejAzAqdwg4

🗓️August 15
📌@UofG_HHNS!
🏛️#UofG #UofGCBS

[Kyle Medak @MedakKyle]

Article online now. Work from the Wright lab using GLP-1RA and amylin.
https://t.co/VnOgCZPj66

[Logan Townsend @LoganTownsend86]

Check out our new review where we discuss all things AMPK!

AMPK and the endocrine control of metabolism
@DrGregSteinberg

https://t.co/kxws6KvlPH

[Daniel J Drucker @DanielJDrucker]

GLP-1R signaling attenuates a variety of addiction and dependence-linked CNS pathways in mice and rats-will a subset of this data set for nicotine, alcohol, cocaine, and opioids translate in humans? @PsychopharmEBPS https://t.co/V2UQvW7pt8

[HHNS at UofG @UofG_HHNS]

🍾CONGRATULATIONS DR. MEDAK!👍
📢Kyle Medak, PhD, Successfully Defended His Thesis!

💊Attenuation of Acute Olanzapine-Induced Metabolic Dysfunction
🎯Novel Co-Treatment Strategies!
🔗https://t.co/KDulF540b6

🗓️Thurs, April 27
📌Food Sciences, FS 146

🎓#PhDGrad
🏛️#UofG #UofGCBS

[HHNS at UofG @UofG_HHNS]

📢KYLE MEDAK, PhD Candidate, Will Defend His Thesis!
💊Attenuation of Acute Olanzapine-Induced Metabolic Dysfunction
🎯Novel Co-Treatment Strategies!

⏰10 am
🗓️Thursday, April 27th, 2023
📌Food Sciences, Room FS 146
🏛️#UofG #UofGCBS

[Daniel J Drucker @DanielJDrucker]

Studies in mice @MedakKyle reveal that increased both active and total GLP1 protected against olanzapine-induced perturbations in lipid and glucose metabolism @FrontPharmacol https://t.co/lEXWi9mqx6

[HHNS at UofG @UofG_HHNS]

📢PUBLISHED!
🗞️Frontiers in Pharmacology

💊Treatment Alleviates Metabolic Side Effects of #Olanzapine!
🔎https://t.co/pRK3OdCpsZ

🎓Kyle Medak, PhD Student @UofG_HHNS!
🔬Prof. David Wright's Lab Team @UofGResearch!
🔗https://t.co/KDulF540b6

🏛️#UofG #UofGCBS
🍭#Hyperglycemia

[Logan Townsend @LoganTownsend86]

Interesting work on #keto and olanzapine from the Wright lab. @UBC was smart to recruit this group! @MedakKyle

[Greg McKie, PhD @mckie_greg]

Pleased to see this model from my final PhD study (PMID: 35157333) chosen as the @FASEBorg cover image for the March and April issues. This model depicts the effects of topical menthol application on BAT thermogenesis. S/O to coauthors @HeshamShamshoum @MedakKyle @UofG_HHNS

[Logan Townsend @LoganTownsend86]

Shout out to @MedakKyle and the twitter-less Alyssa Weber on this one! Easy write a commentary when the original article is so good! @Hagberglab

[HHNS at UofG @UofG_HHNS]

⏰JUST PUBLISHED!
🗞️bioRxiv

🐀Training-Induced Rat Longitudinal Muscle Growth
⏱️May Improve Dynamic Performance!
🔎Read How: https://t.co/HrpOIwZpps

🎓Avery Hinks, MSc Student @UofG_HHNS!
🥼Prof. Geoff Power's Lab Team @UofGResearch!
🔗https://t.co/PQP62JCB5m

🏛️#UofG #UofGCBS

[Logan Townsend @LoganTownsend86]

More great work form the Wright lab. Maybe the coolest part of this is the clear evidence that adrenergic resistance is downstream of the receptor, contrary to what some recent "prestigious" papers suggest. Good job @MedakKyle

https://t.co/xrm1o2OLaq

[HHNS at UofG @UofG_HHNS]

⏰JUST OUT!
🗞️Physiological Reports
🔓Open Access!

🔎Important Co-Treatment Strategies!
🍭Potential Glucose Metabolism Regulation!
🔎https://t.co/7UmxPOvXc6

🎓Kyle Medak, PhD Student @UofG_HHNS!
🥼Dr. D. Wright's Lab Team @UofGResearch
🔗https://t.co/KDulF540b6
🏛️#UofG #UofGCBS

[Logan Townsend @LoganTownsend86]

Cool new paper out of the Wright lab looking at the cold-mimetic menthol on thermogenesis. Probably a stupid thought but I couldn't help but wonder about menthol cigarettes! @mckie_greg @HeshamShamshoum @MedakKyle

https://t.co/N0pQbk7O2M