@bryan_johnson Meibomian gland dropout is very common. Optometrists known about this since second year optometry school. Get your eyes checked annually and make sure they are looked at. Warm compresses and oral EPA are easy things to do.
You're 35. Your glasses prescription was −2.00 at 18. It's −5.00 now.
You can't see anything without glasses these days at all.
You spend 9 hours on screens. You wear your glasses. You just got a stronger pair. You've stopped bringing it up.
You don't have a vision problem. You have a signal problem.
In 2010, researchers at Queensland University put 28 adults under one hour of hyperopic defocus — the same type of blur your glasses create when you look at a screen.
Axial length increased by +8 µm. -> Eyesight is measurably worse, in ONE HOUR.
They tried the opposite — myopic defocus. Same 60 minutes. Same subjects.
Axial length decreased by −13 µm. -> Vision measurably improves, with eyeball LENGTH reducing.
One blur grows your eye. The other shrinks it. p < 0.0001. (Read et al., IOVS 2010)
Your optometrist lens subscription seller gives you full correction for distance. You wear that same prescription to look at a phone 30 cm from your face.
Your eyes under-accommodate. Research confirms myopes have ~2× the accommodative lag of emmetropes — about 0.6 D of hyperopic defocus at near. (PMC9544228)
That's the same signal that made the +8 µm happen. Every screen session. Every year.
In 2023, a JAMA Pediatrics RCT (n=263) found that naked-eye 3D vision training — creating myopic defocus — reduced axial elongation by 24%. With high adherence, 40%. (Xie et al., JAMA Pediatr 2024)
A 2025 study (n=208) showed visual training dropped axial elongation from 0.38 mm/year to 0.23 mm/year — 39.5% reduction. And it was additive — it worked on top of orthokeratology, atropine, and defocus lenses with no statistically significant difference between combinations. (Xu et al., Clin Optom 2025)
In 2025, a preprint documented full reversal of −6.00 D myopia in an adult in 5 months — using only myopic defocus and consciously triggered accommodation. n=1, not peer-reviewed. But the trajectory is suggestive. (Martinez-Saito, OSF 2025)
The industry has known since 2002 that passive undercorrection backfires. The Chung study showed giving kids −0.75 D blur with no training made things worse. Critics cite this endlessly. They ignore that it tested passive blur — not differential lenses + active focus. Apples and hand grenades.
The endmyopia approach is different:
Wear differential lenses (1.5–2.0 D weaker aka "computer glasses") for close work — eliminates the hyperopic defocus stimulus entirely
Wear normalized lenses (slightly weaker) for distance — creates mild myopic defocus
Active focus — consciously clear the blur, retraining the ciliary muscle
Two roads. One is a lifetime lens subscription sold by retail optometry, the other is you taking back control.
Keep feeding your eyes the signal that says "grow longer, clearer" — 8 hours a day, every day.
Or fix the signal.
Nobody is coming to tell you this. They make 150 billion dollars a year counting on you not figuring it out.
@bryan_johnson I think so, and lot of misinformation about UV sunglasses and melanin production. Although eye parameters are the basis for David Sinclair's anti aging study
UV is the prime risk factor for macular degeneration, cataracts, ugly pinguecula, and nasty lesions around the eyelids
👀 We see upside down on the retina because light bends when it passes through the eye’s lens.
The lens makes light rays cross, flipping the image vertically and horizontally.
This upside-down image falls on the retina at the back of the eye.
The brain receives this information through the optic nerve.
It automatically turns the image upright, so we perceive the world normally.
In anticipation of the first epigenetic age reversal drug candidate ER-100 going into humans, here is our latest collab review:
"Oculomics and AI: The eye as a biomarker for health span" https://t.co/nO9ONjOX5a
@paulsaladinomd During the morning while the UV index is low, yes. After ~10am, your risks of macular degeneration, cataracts, pinguecula,etc not to mention aging, wrinkles around the eyes all go dramatically up. Poor advice.
The simplest defense against digital eye strain (DES) is
the 20-20-20 rule:
Every 20 min of near-work, look at something ≥ 20 ft away for ≥ 20 s.
The rule has been around since the 90s and endorsed by the American Optometric Association.
A 2025 study found that taking 20 second breaks from reading on screens for 40 mins cut self-reported eye irritation/strain scores, versus continuous viewing. And it halved near-work-induced transient myopia persistence (p < 0.05).
@paulsaladinomd During the morning while the UV index is low, yes. After ~10am, your risks of macular degeneration, cataracts, pinguecula,etc not to mention aging, wrinkles around the eyes all go dramatically up. Poor advice.
If you focus on the central spot, the others vanish
This phenomenon is called 'motion-induced blindness' losing sight of stimuli that are in plain view. The dots don’t actually vanish your mind just perceives it that way.