Mette Q Ludwig

Research Scientist @NovoNordisk | Using single-cell omics and human genetics to study central control of metabolism 🧠🍔 | Funky-jazzaholic 🥁

[Mette Q Ludwig @metteludwig]

What cell populations in the brainstem regulate appetite? Our single-cell study of the dorsal vagal complex identifies a role of GLP-1 and calcitonin receptor neurons and is out now in @NatMetabolism! https://t.co/OLgml0fOIv

Tweetorial:

[Mette Q Ludwig @metteludwig]

Checking in at Obesity Week #OW2022 in San Diego. Excited to be presenting our work on the Transcriptional states underlying cagrilintide signaling in the dorsal vagal complex on Friday (32AB 1.45 pm PDT). With @tunepers, Martin G. Myers, and @novonordisk.
@Metabolcenter

[Mette Q Ludwig @metteludwig]

Happy to have contributed to this review with @tunepers, @seeleyrj and Martin G. Myers! 👇

[Daniel J Drucker @DanielJDrucker]

After decades in the limelight, the hypothalamus shares the stage with the hindbrain and circuits controlling food intake @NatMetabolism https://t.co/rEA8DUgckY

[Daniel J Drucker @DanielJDrucker]

More data in mice highlighting anti-aversive GIP action via brainstem GIPR circuits-GIPR neurons project locally and selectively inhibit nausea-related GFRAL neurons @CellReports https://t.co/FMtg13PUOV

[Daniel J Drucker @DanielJDrucker]

More insight into GABAergic LepRbGlp1r neuronal populations and crucial roles in the control of food intake and body weight by #leptin in mice @biorxivpreprint #obesity https://t.co/Mq1YcpoHZv

[Javier Santoyo @jsantoyo]

Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data. #scRNAseq #CellSubpopulations
https://t.co/NVoz3j4IhQ @NatureBiotech

[Daniel J Drucker @DanielJDrucker]

Preclinical studies of GIP action on aversive pathways lead to the prediction that "combinatorial pharmaceutical targeting of GLP-1R and GIPR will increase efficacy in treating #obesity and #diabetes by reducing nausea and vomiting"
https://t.co/12lAaupBaZ

[Mette Q Ludwig @metteludwig]

The brainstem may be important for the effects of GLP-1 and GIP receptor agonists on body weight. How can advancing single-cell techniques be applied to study incretin action in the brainstem?🕵️We wrote a review on this. https://t.co/wwbRlRHtxq @tunepers @pvtodorov @Metabolcenter

[From the Labs at Baylor College of Medicine @BCMFromtheLabs]

Are you interested in #GIP, a gut #hormone with broad effects on #appetite, #satiety, #obesity and #insulin secretion? Don't miss Drs. @MakotoFukuda5 @bcmhouston and @tunepers @uni_copenhagen talk at the upcoming @ADA_DiabetesPro meeting: https://t.co/1rZS5gNRM2

[Mette Q Ludwig @metteludwig]

Excited for this 👇💻

[NNF Center for Basic Metabolic Research (CBMR) @Metabolcenter]

📢#AIM2021 speakers on June 16:

🔵Hillary Finucane 🏫@broadinstitute
🔵@aiden1doherty 🏫@bdi_oxford

Read more about their presentations, and register for free, now! 👇

https://t.co/wyPCA82tor

[Samuel J. Walker @walkersamuelj]

Absolutely foundational work from my pioneering labmate Ken Tao and @AUGCsoup, figuring out the wiring logic of vagus motor neurons:

https://t.co/x9oBgKdlft

[NNF Center for Basic Metabolic Research (CBMR) @Metabolcenter]

#AIM2021 kicks off today! 🎉

Tune in from 16:00-17:30 CET for @pedrobeltrao
& @Prof_Lundberg.

Read more about their presentations, and register for free, on our website!

👇

https://t.co/wyPCA82tor

[Center for Integrated Cellular Analysis @cegs_ica]

Fantastic paper from @icclarker @CrisGV85 @mwheeler0 and @QuintanaLabHMS introducing RABID-seq, which virally barcodes connecting cells in the CNS, and investigates the effects of cellular interactions on single-cell gene expression https://t.co/2eDfnTSj2A

[Tore Christiansen @TBergishagen]

Mapping of cell populations in the brainstem bodes well for future obesity treatment
@metteludwig @DDA_Denmark & @Metabolcenter funded phd student. https://t.co/TGLHwsGLhu of international publication in @NatMetabolism Congrats. @tunepers
https://t.co/CF8Tobfqjt

[UCPH Healthscience @UCPH_health]

The scientists believe the approach will unlock more secrets about the neurological control of appetite and energy balance #dkforsk https://t.co/0FQqTr9VZd

[John Morris @johnomix]

Delighted to share work from my postdoc, co-advised by @nevillesanjana and @tuuliel! It began with wanting to identify target genes for GWAS with CRISPR screens and single-cell seq. Brief look below, with shout-outs to my amazing co-authors!

Link: https://t.co/uPe3qVSspS

[Lundbeckfonden @lundbeckfonden]

Danske forskere har dirket hjernens fedmeboks op. Studiet er publiceret i @NatMetabolism og åbner for ny viden om celler der er med til at regulere fedme. Peger på nye former for medicin mod overvægt.
https://t.co/CsaGdtIAYa

@tunepers
@metteludwig
@metabolcenter
@novonordiskfond

[Tune H. Pers @tunepers]

Mapping brainstem cell types relevant to obesity 🌿

https://t.co/9rEjbgPw0J

Thx to @metteludwig @metabolcenter for the hard work & thx to Martin G. Myers @UMich, @lotte_bjerre & collaborators for their inputs, and @novonordiskfond @lundbeckfonden for financial support.

[NNF Center for Basic Metabolic Research (CBMR) @Metabolcenter]

'A #genetic map of the mouse dorsal vagal complex and its role in #obesity' in @NatMetabolism

CBMR's @tunepers and @metteludwig used an unbiased approach to characterize brainstem cell population that anti-obesity drugs likely act to reduce appetite.

🌐https://t.co/jDO40skyCo

[Mette Q Ludwig @metteludwig]

This has been an enjoyable team effort between the Martin Myers lab, Charles Pyke, @lotte_bjerre, Anna Secher and their team at @novonordisk, and my amazing colleagues at the @tunepers lab at the @Metabolcenter. Looking forward to future collaborations! (7/7)

[Mette Q Ludwig @metteludwig]

What cell populations in the brainstem regulate appetite? Our single-cell study of the dorsal vagal complex identifies a role of GLP-1 and calcitonin receptor neurons and is out now in @NatMetabolism! https://t.co/OLgml0fOIv

Tweetorial:

[Mette Q Ludwig @metteludwig]

Thus, dorsal vagal complex cell populations associated with obesity predisposition suppress feeding and may represent therapeutic targets for obesity. (6/7)