Adrian Chek

🇲🇾@🇯🇵
Structural biologist interested in enzymology and enzyme biochemistry.
New hobby into protein engineering to enhance the performance of the enzymes.

[NAISTバイオサイエンス領域 @NAIST_BS]

First crystal structure of full-length PHA synthase (PhaC) — key to bioplastic production! See Chek et al., Angew. Chem. Int. Ed. e202504626. A NAIST–Kaneka collaboration.

#PHAsynthase
#Biodegradable
#Hotpaperinenzymemechanisms
#環境微生物学研究室 #吉田昭介研 #NAISTバイオ

[Isomorphic Labs @IsomorphicLabs]

How could #AlphaFold 3 transform drug discovery?

Most drugs are small molecules known as ligands that bind to proteins to change how they interact in human health and disease.

AlphaFold 3 can predict these interactions to atomic accuracy.

[nature @Nature]

Surgeons in Japan have transplanted kidney tissue from one rat fetus to another, while the recipient was still in its mother's womb https://t.co/vfObVYFdPi

[Institute for Protein Design @UWproteindesign]

RF Diffusion was developed by a team of computational biologists from @UWProteinDesign, @Columbia & @AIHealthMIT.

Our thanks to @sokrypton for implementing it onto the ColabFold platform.

https://t.co/BRLdZaObq1

[The FEBS Journal @FEBSJournal]

🗣️Words of advice: teaching #MacromolecularCrystallography🗣️
🖋️By Bharath Srinivasan @bharath_IGC
A comprehensive guide for teachers & students, including a detailed history & overview of #crystallography, & textbook & software/programs recommendations.
➡️https://t.co/QufsU1Vooc

[NAISTバイオサイエンス領域 @NAIST_BS]

奈良先端大での秋、美しい紅葉を満喫しました！

We enjoyed stunning fall foliage at NAIST this autumn!

#NAISTバイオ　#環境微生物学研究室　#紅葉

[Structural Biology @ActaCrystD]

At local resolutions worse than 2.5 Å, model-building, refinement and validation procedures break down and do not ensure reliably correct models. How can this be addressed? #OverfittingAtLowResolution #MachineLearningPredictions #CaBLAMValidation https://t.co/TR67zQ4jTR

[Adrian Chek @MFChek]

How the coronavirus infects cells — and why Delta is so dangerous https://t.co/AcojPL3HuP

[Structural Biology @ActaCrystD]

Karan Wangpaiboon et al.: A GH13 α-glucosidase from Weissella cibaria uncommonly acts on short-chain maltooligosaccharides #AmylaseFamily #Glucosidase #CovalentIntermediate ... #IUCr https://t.co/2mr6k9DR9L

[LaunchStuff @LaunchStuff]

Chang'e 5 rendezvous, first robotic lunar docking, sample capsule transfer to return capsule.
📸：CNSA/CLEP
ℹ：https://t.co/xP7FULCtp4

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The 2020 #NobelPrize in Physiology or Medicine has been awarded jointly to Harvey J. Alter, Michael Houghton and Charles M. Rice “for the discovery of Hepatitis C virus.”

[Adrian Chek @MFChek]

https://t.co/QhM7n3l5I9

[Adrian Chek @MFChek]

Nine Nobel Prize Predictions for 2020 https://t.co/pTFORbwUxF

[Adrian Chek @MFChek]

Young ones should dream big with actions. If the youth of a nation have no dreams and ambitions, we should be worry. Success or fail, it doesn't mean everything. Just do it.

[Syed Saddiq @SyedSaddiq]

Terima kasih Tun.

Kami terima kritikan dengan hati yang terbuka.

This is a party led by Youths FOR ALL MALAYSIANS.

Majoriti yang akan memimpin adalah golongan teknokrat, profesional, usahawan, Petani moden, civil society leaders dll

We may be Young, but we love Malaysia 🇲🇾💪🏻

[Adrian Chek @MFChek]

Interesting!

[Laura Kiessling @ChemicalBiology]

The latest from the Schultz lab @scrippsresearch: introduction of a single noncanonical amino acid leads to drastic increase in thermostability for a key enzyme in the methionine biosynthetic pathway. Mutant protein has a melting temp of 76 C! https://t.co/slDDtxl5yI

[iScience journal @iScience_CP]

Scientific Editor, @RituChakra, selected a few articles on the topic of molecular and chemical structures that she finds particularly interesting, and we're sharing them with you! Check out the selection: https://t.co/srhPgAWHNT

[iScience journal @iScience_CP]

And a bonus blog post from @RituChakra about her own research journey and the importance of interdisciplinary training! @CellMentor

https://t.co/c8z2uOlgvT

#ECRs #interdisciplinary

[rcsb pdb 💉🧬💻🔬💊🌱🧠🦠 @buildmodels]

New article at PDB-101 by @dsgoodsell looks at Passive Immunization with Convalescent Antibodies. Purified antibodies may be used to treat infection by coronavirus
https://t.co/vNStgOYtuW

[Dr Mahathir Mohamad @chedetofficial]

MY RESIGNATION

1. Today we have a Government with the slimmest majority – just 2.

2. How did this happen?

[Adrian Chek @MFChek]

https://t.co/rO29NI2jCE