Benefits plateau around 10,000 steps, with no minimum threshold observed. Incidental steps help, but purposeful, brisk ones yield stronger reductions. Followed for 7 years, data from wrist accelerometers. Published in JAMA Internal Medicine, 2022.
https://t.co/LpTBe9zDOH
A UK study of 78,500 adults (avg. age 61) found that up to 10,000 daily steps cuts all-cause death risk by 40-50%. Cancer mortality dropped by up to 40%, and CVD by 50%, with similar gains. Higher step intensity (peak cadence) added extra protection beyond total volume.
Men face a steeper rise than women, with effects peaking in early/middle career stages.
Risk hits hardest in the first 10 years post-unemployment, then eases—suggesting acute stress drives early deaths.
https://t.co/OvmJmsBUdb
Unemployment boosts all-cause mortality risk by 63% among working-age adults, per a meta-analysis of 42 studies (20M+ people).
This hazard ratio (HR 1.63) holds after adjusting for age and covariates, signaling a strong link beyond chance.
Elevated cystatin C levels raise cardiovascular death risk by 174% in the general population over age 40. A meta-analysis of 9 studies (38,854 participants) found highest vs. lowest cystatin C categories linked to 72% higher all-cause mortality (HR 1.72, 95% CI 1.37-2.16).
High cardiorespiratory fitness cuts all-cause mortality risk by 45% compared to low fitness levels.
A meta-analysis of 37 studies with over 2 million people found that top vs bottom tertiles of CRF had a relative risk of 0.55.
Psoriasis patients with severe disease face a staggering 297% higher risk of death from liver disease compared to the general population. This comes from a 2019 systematic review and meta-analysis that pooled data from 12 cohort studies.
https://t.co/F7FjRpbBkV
Highest soy intake was linked to 31% lower overall cancer risk (RR 0.69).
This comes from a 2024 meta-analysis in Nutrients.
It pooled data from 52 observational studies worldwide.
Total population: 861,372 adults, with 44,932 cancer cases.
Soymilk showed the greatest protection: +30 g/day → 46% lower risk.
Tofu also protective: highest intake → 22% lower risk.
Dose–response was clear: every +54 g/day soy → 11% risk reduction.
The effect was consistent across Asia, USA, and Europe.
https://t.co/SXt4MMn4IP
Animal protein intake linked to +11% cardiovascular mortality (highest vs lowest).
Systematic review/meta-analysis of 12 cohorts, 483,615 adults, 68,876 deaths.
Where: North America, Europe, Asia, plus one multi-country cohort.
Plant protein (highest vs lowest): −8% all-cause mortality.
Plant protein (highest vs lowest): up to −10% CVD mortality (borderline).
Total protein: no clear association with all-cause/CVD/cancer mortality.
Dose–response: each +3% energy from plant protein → −3% all-cause, −5% CVD.
Each +3% energy from animal protein → ~+2% CVD (not significant).
https://t.co/sIo6uG0Dy0
Eating less than 8 hours a day was linked to a 135% higher risk of cardiovascular death compared to 12-14 hours.
This study analyzed 19,831 US adults from NHANES surveys.
It was conducted in the United States.
Eating duration <8h showed HR 2.35 (95% CI 1.39-3.98) for CV mortality, but no significant link for all-cause (HR 1.40) or cancer (HR 1.27).
The lowest risk was in the 12-14 hour eating duration group, used as reference with no elevated mortality.
Other durations like 8-10h (HR 1.11 for CV) and >16h (HR 0.89 for CV) showed no significant increases.
https://t.co/5vDm9lmH2b
Short telomeres raise cardiovascular mortality risk by 29%.
A study of 12,199 adults examined leukocyte telomere length and mortality.
The research combined data from cohorts in the US and Germany.
Shortest telomeres linked to 23% higher all-cause mortality risk.
They also increased cardiovascular mortality risk by 29%.
Cancer mortality risk rose by 10%.
Follow-up spanned up to 21 years.
https://t.co/VBZjIQZw0K
Drinking up to 4 cups of coffee per day reduces all-cause mortality risk by 14%.
This dose-response meta-analysis included 31 studies with 1,610,543 individuals.
All-cause mortality risk decreased (RR=0.86, 95% CI=0.82-0.89) up to 4 cups/day.
Cardiovascular mortality risk dropped (RR=0.85, 95% CI=0.77-0.93) up to 4 cups/day.
Among non-smokers, each cup reduced all-cause risk by 6% (RR=0.94, 95% CI=0.93-0.96).
https://t.co/16PS3BbyPG