Michael Polansky

@outerbio · Hawktail · @parkerici · @bunsenstudio · @hauslabs

[Michael Polansky @michaelpolansky]

@OuterBio Read the bioRxiv preprint here: https://t.co/lHr3D2j5JR

[Michael Polansky @michaelpolansky]

I'm excited to introduce @OuterBio and Yuna, the ex vivo human skin platform our team has been building for the past several years. Yuna keeps living, full-thickness human skin viable and observable for four weeks, with native tissue architecture preserved.

Innovation in skin health has been slow for decades, and part of the reason is that outside the body, human skin has only stayed usable for about a week. Yet key biological processes such as collagen rebuilding, inflammation resolution and damage accumulation take far longer than that. The field has been reading the opening days of a process that plays out over a month.

Yuna extends that window and pairs it with machine learning in a closed loop, so every experiment sharpens the next prediction.

Our bioRxiv preprint shows Yuna holding three distinct skin biologies across four weeks: psoriasis-like inflammation, senescence in aged donor tissue, and UVB stress response. In each case it returned the known answer when challenged with an established intervention.

Thank you to KJ Jang, Chris Hinojosa, Stan King, and the rest of the incredible Outer Bio team.

https://t.co/DJqS0VHfYQ

[Michael Polansky @michaelpolansky]

Read the bioRxiv preprint here: https://t.co/lHr3D2j5JR