Michael Mints

MD PhD, Computational Biologist @weizmannscience. Exploring head and neck cancer one cell at a time when not shredding pow.

[Michael Mints @micmints]

Experimentalist, computational biologist or jack-of-all trades looking for a great postdoc opportunity in Sweden? I can really recommend @SchlisioSusanne at @karolinskainst , where you can study intra-tumour heterogeneity in neuroblastoma
https://t.co/sMFaW5mwuz

[Michael Mints @micmints]

@Asfyxi @avoforever Ta en tur förbi Hervey Bay om du har tid, kan simma med valar och dyka där!

[Tirosh Lab @TiroshLab]

We’re excited to share our preprint on spatial organization in glioblastoma: https://t.co/OTaanCDDXG. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal a five-layer organization of cellular states and highlight a role of hypoxia as tissue organizer. 1/

[Tirosh Lab @TiroshLab]

1. Excited to share our new paper in @Nature! With over 1000 tumors analyzed by scRNA-seq, we provide a systematic pan-cancer characterization of transcriptional intra-tumor heterogeneity (ITH)
https://t.co/u1aHEatzVz

[Michael Mints @micmints]

@Asfyxi Jamen dåså, kör hårt!

[Michael Mints @micmints]

So that figure had a transparent background.. new version here

[Michael Mints @micmints]

Happy to share our latest work (https://t.co/5sCKzouUAv), published in @NatureGenet, where we show that HPV is repressed in a subset of cancer cells in HPV-driven oropharyngeal cancer, making them more resistant to chemo/radiation treatment! 1/8

[Michael Mints @micmints]

Cell line studies showed that HPVon cells are preferentially killed by chemo/radiation, while HPVoff cells are resistant due to their non-proliferative state. We also showed that HPV DNA copy numbers are not affected, suggesting epigenetic regulation. 6/8

[Michael Mints @micmints]

@TalalZarif1 @NatureGenet Thanks! No, the patient numbers are too small to do proper group (rather than intra-tumour) comparisons, but we are working on a larger bulk cohort where this is a very relevant question!

[Michael Mints @micmints]

And thanks for previous support from @sls_sv ,@karolinskainst ,@umeauniversity !

[Michael Mints @micmints]

Here's a link to the full text:
https://t.co/W5b2VpSDIH
#SingleCell
#Headandneck
#CancerResearch
#HPV
#Genomics