Interesting review on updated systemic treatment strategies for #metastatic#colorectalcancer according to molecular alterations and genetic profiles of colorectal malignancies.
https://t.co/f2lo7Hcn8n
One of our brilliant residents showed me this case. Supraclavicular lymph node. No other clinical information at the moment.
Micropapillary to papillary structures, some mitoses, some mucin production.
(Short thread follows):
44-year-old underwent radical hysterectomy for cervical mass extending to parametrium. She is alive 34 years after the surgery. Pick your diagnosis: A. Squamous cell carcinoma; B. Epithelioid leiomyosarcoma;C. Epithelioid trophoblastic tumor;D. Placental site trophoblastic tumor.
This week's s/o is getting more & more interesting. Look what I found in this "gastric polyp". Another zebra! Hint: Patient has a history in head&neck. Anyone care to guess? #PathTwitter#gastric#stomach
4/ In 2016, the Peritoneal Surface Oncology Group International (PSOGI) codified their definition of LAMN, which I like. First, it has to be an epithelial neoplasm. This rules out many mimics in the differential diagnosis (which I’ll discuss later). Ref: https://t.co/9ty5f3fVWo
Endoscopic fine needle aspiration of a mass in the head of the pancreas. What is the diagnosis? Answer: https://t.co/SawDaUvCEp #CytoPath#PathTwitter#PathArt#Cytology
7/ ⚠️A pitfall to beware of is that MDM2 IHC can be positive in histiocytes (including multinucleated giant cells)⚠️
8/ That’s said, FISH should come to the rescue ….
https://t.co/9D0lFLzRE3