Daniel Kane

Exercise Physiology @stfxuniversity

[Daniel Kane @mitokanedria]

“...Time is the fire in which we burn.” -Delmore Schwartz

🪡 🧵 thread about #lactate oxidation and metabolic heat 🔥. /1

https://t.co/1GtHz17z5e

[Cameron A. Schmidt, PhD @CAS_ReproLab]

Wonderful to have played a small role in this effort. This century of biochemistry will place the staggering numeracy in the systems we study at the forefront of our science. Looking forward to more thinking like this👏 #Biochemistry #Redox #Bioenergetics

[Cameron A. Schmidt, PhD @CAS_ReproLab]

Here's the link to the paper. Download in the next 50 days for free! @ECU_Biology @ECUResearch @EastCarolinaDOI https://t.co/tMDmqGSyfI

[Daniel Kane @mitokanedria]

@jwhitfie @brianglancylab @LBruceGladden Naked mole rats are awesome!

[Benjamin Bikman @BenBikmanPhD]

New publication from my lab about the metabolic (mitochondrial) effects of Yerba Mate (YM). We found disparate effects of YM in fat tissue and muscle tissue. In fat, YM increased metabolic rate (via greater mitochondrial uncoupling). However, in muscle, YM had no such effect--mitochondria were as efficient as ever. Overall, a uniquely beneficial series of changes that helps explain the general observations of YM facilitating weight loss and exercise performance. @dan_hues @Unicity https://t.co/vYSQ4zYpkn

[Daniel Kane @mitokanedria]

@ChrisPerryMito @dhood_york @MHRC_YorkU Congratulations!! Excellent news!!

[Daniel Kane @mitokanedria]

@Xin_Cai_ @UTSWNews @UTSW_RadOnc Interesting!

Might the increased rate of oxygen consumption with lactate be due to its potential electrogenic accrual in mitos, as recently reported (https://t.co/nQz54oC1CQ)?

[Feng Zhang @zhangf]

Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in @Nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. https://t.co/aKLMMEBRkk

[Daniel Kane @mitokanedria]

🔥thread alert: origins of the Crabtree effect

[Lydia Finley @lydfinley]

Time for summer fun 🌞⛱️: let's talk about the Crabtree effect 🦀🦀, an ultimate #metabolismclassic, describing the ability of glucose to represses mitochondrial respiration https://t.co/JSqyd1et3p 1/n

[Daniel Kane @mitokanedria]

@lydfinley Thank you for this🔥thread!

Do you think it would be fair(er) to say the Crabtree effect = inhibition by glycolysis, rather than by glucose?

Experiments in which respiration is rescued by poisoning glycolysis (e.g., with iodoacetate) seem to support.

https://t.co/p9ZZfuM6yw

[Daniel Kane @mitokanedria]

The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat.

By P.W. Stacpoole and C.E. McCall.

2023.

🔥

https://t.co/a4Jm1NapSK

[Daniel Kane @mitokanedria]

@WeightInnovate Interesting!

Perhaps related(?): https://t.co/oJRqPSI9JK

https://t.co/fxENHZ9os5

[Daniel Kane @mitokanedria]

“In conclusion, lactate is less effective than glucose and potentially detrimental during neural network rhythms featuring high energetic costs, likely through the lack of some obligatory ATP synthesis by aerobic glycolysis at excitatory and inhibitory synapses.”

[Iñigo San Millán @doctorinigo]

Lactate as a supplemental fuel for synaptic transmission and neuronal network oscillations: Potentials and limitations - PubMed https://t.co/KZyrMnSZaz

[Daniel Kane @mitokanedria]

@DrMarkBurnley No perfectly accurate terminology, but this seems quite close.

[Daniel Kane @mitokanedria]

Ruh-roh! Concentration dependent?

[Joachim Goedhart @joachimgoedhart]

Dramatic change in the shape of mitochondria after addition of digitonin

[Kelsey Fisher-Wellman, PhD @KFW_Lab]

Excited to announce our group's latest preprint led by @IlyaNBoykov + @Mcmontgomery11
https://t.co/6ugOG5Vm1Q

In it we compared OXPHOS expression/function, across various murine tumor types, matched normal tissues and other organs -- all normalized to mito content.

🧵below

[Daniel Kane @mitokanedria]

@oval_MetFlex And as if the plot weren’t already thick enough, there’s this: https://t.co/UCRc4yXgZs

[Daniel Kane @mitokanedria]

@BobbyRaeburn Took me a second 😂

[Daniel Kane @mitokanedria]

The periodic table of elements came to Mendeleev in a dream?! https://t.co/TlIHEKaNWl

[Daniel Kane @mitokanedria]

A mechanistic link between the hyperglycemia of T2D and Alzheimer’s Disease involving KATP channels 👇