Mary Prahl, MD

Pediatric Infectious Disease Physician-Scientist | Parent | Avid hand-washer | Translational Immunology

[UCSF Pediatrics @UCSFPediatrics]

Meet Dr. Victoria Chu, @UCSF Pediatrics' new faculty member in infectious diseases. From leading @CDCgov #COVID19 response teams to pioneering research on neonatal infections, she’s advancing public health & pediatric care.

@NIAIDNews
https://t.co/LKQokKnwic

[ISSCR @ISSCR]

🎉Congratulations to ISSCR Education Committee Member Carolyn Sangokoya, MD, PhD for being honored as a 2024 Chancellor Award for Diversity recipient! @RnaHelix @UCSF

[JAMA Pediatrics @JAMAPediatrics]

Juvenile Onset Recurrent Respiratory Papillomatosis (JORRP) incidence has decreased since the introduction of HPV vaccination. https://t.co/SB3fzRyw4z

[Prof. Christina Pagel - @chrischirp.bsky.social @chrischirp]

Important 🧵on our new peer-reviewed paper:

The pandemic is as bad as it ever was for babies - in year to Aug 2023, 6,300 babies under 1 were admitted to hospital wholly or partly BECAUSE of Covid.

They are ONLY age group where admissions have NOT gone down over time 1/17

[JAMA Network Open @JAMANetworkOpen]

#SARSCoV2 infection during pregnancy was not associated with changes in neurodevelopmental scores through 24-months of age, in this study of >2k mother-child dyads. https://t.co/WpfTUEEYbh

[RNAHɛʟɨӼ🩺🔬 @RnaHelix]

excited to announce the release of this preprint “Coordinate post-transcriptional regulation by microRNAs and RNA binding proteins is critical for early embryonic cell fate decisions” on bioRxiv! 🧵 https://t.co/r3dYkMTdjB

[Natasha Spottiswoode @NSpottiswoodeMD]

https://t.co/1G4Tw13OCh Amazing work by my colleagues and friends Victoria Chu, Abigail Glascock, @annieluet and Chaz Langelier (et wonderful al's) characterizing the effects of Doxy-PEP on the gut microbiome and AMR risk!

[Viki Male @VikiLovesFACS]

🇺🇸 Between Oct 2022 and April 2024, babies under 6 months were as likely to be hospitalised with COVID as 65-75yo.

💉 Of babies hospitalised with COVID, only 5% had mothers vaccinated during pregnancy…

1/

https://t.co/0Jp3xHwFMm

[Allison Bond @AllisonRBond]

Button batteries are so scary - this one caused an esophageal-carotid fistula. Luckily, the kid was ok https://t.co/R6hwjhr1cT

[Eric Topol @EricTopol]

Young children (< 5 years) have a distinct adaptive immune response to #SARSCoV2 infection compared with adults
https://t.co/lQkW6eWfqq @ScienceTM @FillatreauSimon

[Viki Male @VikiLovesFACS]

🇬🇧 53,320 who received at least one dose of #CovidVaccine up to 12 months before #pregnacy vs 133,670 unvaccinated.

👉🏻 Either mRNA or adenovirus (AZ) vaccines reduce risk of very preterm birth by 16%

👉🏻 mRNA vaccines reduce risk of stillbirth by 28%

[Carrie Byington, MD, FAAP, FIDSA @carrie_byington]

NY Paid Family Leave and Prevention of Acute Respiratory Infections in Young Infants

“controlled time series analysis found acute care encounters for ARTI were 18% lower after the introduction of paid family leave than in the absence of the policy.”

https://t.co/Ad2m0HylRc

[Gabrielle Rizzuto @GlycoGabi]

Recruiting a postdoc to study mechanisms of tolerance & immunity in the pregnant host. If you are passionate about this understudied area and excited to discover mechanisms of humoral tolerance to the placenta & fetus, do get in touch. (1/2)

[JAMA Pediatrics @JAMAPediatrics]

Among live-born infants, first-trimester mRNA COVID-19 vaccine exposure was not associated with an increased risk for selected major structural birth defects, finds multisite cohort study. https://t.co/5RP9yaG76f

[Mary Prahl, MD @mkprahl]

@stephanielangel @CWRUSOM Wow, very interesting study. Such an innovative approach

[Carrie Byington, MD, FAAP, FIDSA @carrie_byington]

Health and Economic Benefits of Routine Childhood Immunizations🇺🇸1994–2023

"childhood vaccinations prevented ~508M illnesses, 32M hospitalizations, and 1,129,000 deaths, resulting in direct savings of $540 billion and societal savings of $2.7 trillion."
https://t.co/mBiI0S5HCu

[Eric Topol @EricTopol]

Cracking the case for MIS-C, the multisystem inflammatory in children, a potentially fatal sequelae of Covid: a nucelocapsid proteins mimics a self-protein, unleashing an autoimmune crisis @Nature @UCSFMedicine
https://t.co/FRBaIXky3n

[Carrie Byington, MD, FAAP, FIDSA @carrie_byington]

Molecular mimicry in MIS-C

From @UCSF and others across 🇺🇸: "findings suggest patients w/ MIS-C develop characteristic immune response to SARS-CoV-2 nucleocapsid protein associated w/cross-reactivity to self-protein SNX8 demonstrating mechanistic link."

https://t.co/ms7f80ouxQ

[UC San Francisco @UCSF]

Early in the pandemic, kids were hospitalized with a mysterious disease, MIS-C. A team led by @DrAaron14 @MAndersonUCSF @czbiohub discovered how mild COVID led to MIS-C, hinting at what might go wrong in autoimmune diseases like #MS. @BCH_InTheNews @stjude https://t.co/MNJTXkhd37

[Andres Cardenas @cardenaasca]

We observed greater #epigenetic age acceleration in multiple clocks decades later among children of mothers who performed #agricultural fieldwork during their pregnancy, independent of socioeconomic and environmental influences. Highlights the need to protect #farmworkers health