Professor, University of California, San Francisco
Director, Diabetes Center at UCSF @AtUcsf
President, Fed of Clinical Immunology Societies @FOCISimmunology
LUCKY when one can combine work with friendship. I am very lucky @ucsfhealth w. friends @immunox@UCSFAging & friendly relationships with @UCSF leadership. Excited how this "group of friends" imagined a 2017 dream & very grateful to Bakar family and others to make this reality.
Early in the pandemic, kids were hospitalized with a mysterious disease, MIS-C. A team led by @DrAaron14@MAndersonUCSF@czbiohub discovered how mild COVID led to MIS-C, hinting at what might go wrong in autoimmune diseases like #MS. @BCH_InTheNews@stjude https://t.co/MNJTXkhd37
Microglia can be manipulated to impact CNS control of weight gain and glucose control. But what do hypothalamic microglia do? We now explore this in newborn mice, with fascinating results. Congrats to @MValdearcos and our outstanding team! @AtUcsf@NorcUcsf@UCSF
Insights: @DrCindyMa & @stutangye discuss new study from @MACattackLab (https://t.co/4LLX8joriS) that proposes a role for dysregulated IL-22 production by Th17 cells in causing some aspects of immune-mediated skin inflammation in #STAT3GOF syndrome. https://t.co/oFtMQJ4cjs
Excited to share some new collaborative work with the Kappler lab on how thymic tolerance to insulin is maintained in a model of T1 Diabetes.
Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones | PNAS https://t.co/G4ieFy98hb
Excited to be part of a team that identified a rare family with a defect in PDL1 that has a strong link to type 1 diabetes and other immune dysregulation. https://t.co/h6C98kWQpz
Finalize & Submit your abstract ahead of time ✔️ There's only 3 days remaining to submit your research and be a part of the FOCIS 2024 Annual Meeting!
Don't wait - submit today ⏳: https://t.co/m2pdB6hPDI
Congrats to Mianmian and Tony on this important collaborative work on thymic selection of autoreactive T cells!
Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model | PNAS https://t.co/9x2bWOFLbK
New in @Nature: #COVID patients with specific mutations in NFKB2 gene develop antibodies to type I interferons, which are associated with a severe disease course, often involving hospitalization and ICU care. 🧵 1/5