Updated VISTA Enhancer Browser, 7 years in the making, out in @NAR_Open! >4,500 transgenic in vivo enhancer experiments for all your developmental biology, human variation and #evodevo needs. https://t.co/fE861VE3r7 #enhancers#embryos https://t.co/QxQDzGzBlf
1/🧵Excited to re-introduce Memento in (https://t.co/mxycmsOTkr), a scalable method for differential analysis of scRNA-seq data. It provides first-in-class performance in statistical power and calibration for comparing differences in mean, variability, and gene correlation.👇
Thinking about a PhD using computational power to answer pressing problems in biology and health? @UCSF Biological and Medical Informatics PhD program is recruiting for Fall 2025! Join our info session next Monday Oct 21: https://t.co/jLMUwigeI1.
Beautiful work by @KarissaLHansen and @ElphegeNoraLab on the role of cohesin in enhancer-promoter interactions.
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function https://t.co/9kMAY5T3iP
Beyond stoked to share our latest, entitled “Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording” !
https://t.co/8BtGh7th6P
Incredibly proud to share that I recently joined @UCSF_BTS@UCSF as an Assistant Professor! This means that the Calderon Lab is now open!
Or, more accurately, in the process of opening as I am still unboxing equipment and unraveling giant posters (a last @JSHendure lab gift) 🥳
Our paper describing a scalable method for Multiplex, single cell CRISPRa screening for cell-type specific regulatory elements is now published!
https://t.co/XSq2c5rPY8
https://t.co/ENt5kQ3zJz
Thank you to @KathyGiacomini, Christof Fellmann, David Schaffer, Francine Gregoire, @M_Kyle_Cromer, Emil Kakkis, Andrew Carroll, David Kelley, Danny Wells, Tony Capra, Christina Fan, Andrew Farmer, Wenjun Ouyang, and @YinShenLab for their outstanding 2024 IHG Symposium talks!
An experimental census of retrons, now published in @NatureBiotech. We synthesized more than a hundred new retrons and put them through their paces, improved recombineering rates and precise editing in human cells up to 40%. https://t.co/OoJWUMC9MU
We are recruiting two computational biologists/bioinformaticians with ML expertise and a focus on genomics, variant effects and gene regulatory sequences in staff scientist and postdoc roles in Lübeck, Germany. Please find details here: https://t.co/GbfuDN3gha
Excited to share the white paper for the IGVF Consortium, supported by @genome_gov
Deciphering the impact of genomic variation on function
https://t.co/RxudNoG4QG
Four last days to register! Symposium on 9/9. We have a great lineup of speakers, plenty of time to network and registration is free.
https://t.co/7WF2FPO7aM
Another beautiful story by Ari Daniel (@mesoplodon) @NPR on the Belize bat-a-thon and our work on how fruit eating bats can eat so much sugar and not get diabetes. Amazing work by @GreatWeiShark and Mai Nobuhara!
https://t.co/JPWkCx9hEY
Thrilled to share that I'll be starting a tenure-track assistant professor position at the Department of Genetics, Washington University in St. Louis, in January 2025! @WashUGenetics
I am recruiting lab members at all levels. For more details, visit our lab website or check flyer