Ross Hardison

Biochemist, genome scientist, teacher at Penn State Univ. Genomic approaches to understand regulation of gene expression. Enjoy guitar and hiking.

[Ross Hardison @rosshardison]

My article "Mechanisms of Globin Gene Regulation in Mammals" in #AnnualReviewofGenetics is available at https://t.co/grOfQdBVaV. It summarizes chromatin architecture, #RegulatoryElements, #TranscriptionFactors, etc., with a theme of similarity of mechanisms. Hope it is useful.

[Ross Hardison @rosshardison]

Faculty positions open in Genetics, Cell, and Developmental Biology at PSU; https://t.co/4zFABBzWei

[Ross Hardison @rosshardison]

We used the epigenetic state “alphabet” for many analyses of candidate regulatory elements, motifs, etc. between species. The paper is freely available at: https://t.co/u53R1GYgVm.
Some authors @Guanjue, @mahonylab, @KellerCaponePhD, @rajivmccoy, @yuefeng_1, @ychengsy.

[Ross Hardison @rosshardison]

Excited that we have a paper coming out in @genomeresearch exploring comparisons of epigenetic landscapes between species to find and better understand gene regulatory elements. https://t.co/u53R1GYgVm

[Ross Hardison @rosshardison]

Our sets of candidate cis-regulatory elements (cCREs) in human and mouse blood cells are powerful resources for further research. Their high enrichment in genetic variants associated with blood cell traits suggests they play roles in developing those traits.

[Ross Hardison @rosshardison]

@sroyyors @genomeresearch Thanks - and thank for your encouragement on the NMF approach!

[Ross Hardison @rosshardison]

Our sets of candidate cis-regulatory elements (cCREs) in human and mouse blood cells are powerful resources for further research. Their high enrichment in genetic variants associated with blood cell traits suggests they play roles in developing those traits.

[Ross Hardison @rosshardison]

Focusing on NMF factor 3, associated with positive gene regulation in erythroid cells, brings out the distal element as well as the well-known proximal regulatory elements in the mouse GATA1 gene.

[Ross Hardison @rosshardison]

@wilson_md @PSUScience @PSUStatistics @PSUresearch @BMB_PSU @huckinstitutes Thanks Michael. Hope you like it!

[Ross Hardison @rosshardison]

Got genomic data on > 2 conditions or cell types? Use CLIMB to leverage the power of joint analysis for greater precision and finding meaningful clusters in data. Work from Hillary Koch in Qunhua Li's lab collaborating w/ @KellerCaponePhD @rosshardison https://t.co/GU8HLXUenL

[Ross Hardison @rosshardison]

Love that medley of “Jack Straw”, “China Cat Sunflower”, and “I Know You Rider”.

[Bede Portz @YSPTSPS]

@rosshardison That album is just remarkable, and while it was modified in the studio, that it was essentially a live album is amazing. ‘He’s gone’ from that album is just perfect.

[Ross Hardison @rosshardison]

This is a great paper!

[Prof Kate Quinlan @KateGQuinlan]

Our paper, led by PhD student @SarahTopfer_ is out today in @BloodJournal (https://t.co/jRqENNdLYJ) with a commentary by @rosshardison (https://t.co/CplPUkN1sv), a podcast (https://t.co/E41vHOkg0j) and a great press release by @isadubach!
https://t.co/frU9K9IW2e
@UNSWBABS @UNSW

[Ross Hardison @rosshardison]

One of my favorite "things I was wrong about": When I served on @dermitzakis 's PhD committee, I thought variation in gene expression among individuals was just noise in the measurements. Manolis thought they were genetically determined. He was right!. Now you have eQTLs!!

[Ross Hardison @rosshardison]

Congratulations to Manolis Dermitzakis @dermitzakis for his Outstanding Science Alumni Award from @PSUScience. He got his Ph.D. here with Andy Clark, with some of the earliest description of variation in gene expression among individuals. Pic with Manolis and Steve Schaeffer.