Yin Shen

Professor @ UCSF l Functional genomics: gene regulation in 3D, CRISPR screens, and neuroepigneomics l Opinions are my own.

[Yin Shen @YinShenLab]

Delighted to share our latest work, part of the @ENCODE_NIH project, now published in Nature Communications: https://t.co/D4ys53LLZe
We uncover an enhancer-mediated allelic compensation mechanism that safeguards transcriptional stability of dosage-sensitive genes.

[Xingjie Ren @Xingjie_Ren]

We @YinShenLab are excited to share our work on the functional characterization of enhancers of neuropsychiatric risk genes in human iPSC-induced excitatory neurons using CRISPR tiling deletion screening. https://t.co/sZjg1qkRSo 1/20

[Yin Shen @YinShenLab]

@YangEricLi @WashUGenetics Thank you for hosting me. I truly appreciated the opportunity to engage with both faculty and trainees, and thoroughly enjoyed the visit.

[Yin Shen @YinShenLab]

@rushika_perera @UCSF @Stanford @longlabstanford Exciting! Congratulations!

[Fusion Conferences @Fusion_Conf]

🚨 Don’t forget to register for #Neuroepi25!
⏳ The deadline is fast approaching - Thursday 7th August 2025.
This is your last chance to join; don't miss out on a fantastic meeting!
Click here to register➡️ https://t.co/zLWjCyxTG8
#FusionNeuro #FusionAgingResearch #FusionEpigenetics

[Yin Shen @YinShenLab]

@rushika_perera @Nature @GillesRademaker Congratulations, Rushika and the team! Important findings!

[Yin Shen @YinShenLab]

Excited to see our work on HARs highlighted by @TrendsGenetics—appreciate the feature!

[Trends in Genetics @TrendsGenetics]

The impact of human accelerated regions on neuronal development https://t.co/HsGzRfszFb

[UC San Francisco @UCSF]

How did we evolve brains capable of learning and complex language? @IHG_at_UCSF found that parts of our DNA evolved at hyperspeed, making our brains more complex than apes’, but possibly raising the risk of human brain disorders. https://t.co/QtP0XrcUwm

[Yin Shen @YinShenLab]

Our latest research on human accelerated regions has just been published with @SpringerNature https://t.co/xKCXjjTni0. Congratulations to @MarkTransposon @HanYang_Henry and the team! In this study, we characterize genome variants to function through the lens of evolution.

[Xiekui Cui @MarkTransposon]

How did humans develop unique traits despite sharing nearly identical genomes with other primates like chimpanzees? Together with Han Yang (@HanYang_Henry), our new study on human accelerated regions (HARs) sheds light on this question @ https://t.co/B4yHNIm7ho. 1/12

[Yin Shen @YinShenLab]

Join us for GRC/GRS: Genome Architecture in Cell Fate and Disease this June in Ventura, CA!

[Fusion Conferences @Fusion_Conf]

🌟 SAVE THE DATE! 🌟
The 4th Neuroepigenetics & Neuroepitranscriptomics Conference is returning with its 4th edition! 🎉
Join us for this incredible event, chaired by Hongjun Song (University of Pennsylvania) and Li-Huei Tsai (MIT), in beautiful sunny St Julians, Malta! ☀️
💥 Save the date and stay updated on all the details!
👉 Sign up for updates by clicking here: https://t.co/3Es4M2LblW

[William Allen @weallen1]

In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.

Check it out!
https://t.co/iJ8hi3ddz4

[QBI @QBI_UCSF]

It was both inspiring and enriching to have this remarkable and synergistic group come together for the QBI Chromatin Symposium today!

[Yin Shen @YinShenLab]

@JianXuLab @JunhuaLyu @GuZhimin @YuannyuZhang @MinNiLab_stjude @RJDLab @CRI_UTSW @LilyHuangLab @NIDDKgov @StJudeResearch Congratulations, Jian!

[QBI @QBI_UCSF]

Join us on Nov 18 at @UCSF for the QBI Chromatin Symposium, led by Drs. Vijay Ramani & Yin Shen. This event will showcase the latest in chromatin regulation, from bench to bedside. We look forward to seeing you there next week!

Register now: https://t.co/XUyGw6NYiq

[Yin Shen @YinShenLab]

@martinowk @ENCODE_NIH Thank you, Keri!

[Yin Shen @YinShenLab]

New @ENCODE_NIH preprint from the lab! Through CRISPR screens, we identify functional enhancers for neuropsychiatric disease risk genes in iPSC-derived neurons. We revealed an exciting allelic compensation effect (ACE) on transcription for the dosage-sensitive gene SIN3A.

[Xingjie Ren @Xingjie_Ren]

We @YinShenLab are excited to share our work on the functional characterization of enhancers of neuropsychiatric risk genes in human iPSC-induced excitatory neurons using CRISPR tiling deletion screening. https://t.co/sZjg1qkRSo 1/20

[Yin Shen @YinShenLab]

@hsiung_chris @Xingjie_Ren Thank you, Chris, for the shout-out!

[Yin Shen @YinShenLab]

@afhuming @ENCODE_NIH Thank you, Ming!

[Yin Shen @YinShenLab]

@Katz_Lab @emorygmb @angalus_d @BrainJZhou Thank you for the invitation. It was a pleasure meeting with the students and faculty at Emory. The GMB class model is truly unique—I wish I had experienced a course like that during my graduate studies.

[Yin Shen @YinShenLab]

@FeixiongCheng @NIHAging @CCLRI Congratulations, Feixiong and the team!