Rob Grant

A medical oncologist interested in optimizing cancer care using multimodal models

[Rob Grant @ml4onc]

New research: https://t.co/yU9SdVujO9. We developed and validated a deep learning system to predict survival after pancreatic cancer surgery from pathology slides. Congrats to Avelyn and the team. Thanks to @CDNCancerTrials, PRODIGE, @OICR_news, @pmcancercentre

[Rob Grant @ml4onc]

New research on PSC-associated biliary tract cancer. Amazing work by Kevin, Felix, and the LeGresley Biliary Registry team. Collaboration is key in this rare disease, and it was wonderful to collaborate with Dr. Lee, Javle, and the MD Anderson team https://t.co/DDiN8CtDfS

[Princess Margaret Cancer Centre Research @PMResearch_UHN]

New strategy involving immunotherapy improved progression-free survival for patients with biliary tract cancers, derived from inflamed and scarred bile ducts.

Discovered by team @ml4onc at @UHN @pmcancercentre @OICR_news & @MDAndersonNews.

@CCR_AACR: https://t.co/nDaiAT4c4D

[Princess Margaret Cancer Centre Research @PMResearch_UHN]

New strategy involving immunotherapy improved progression-free survival for patients with biliary tract cancers, derived from inflamed and scarred bile ducts.

Discovered by team @ml4onc at @UHN @pmcancercentre @OICR_news & @MDAndersonNews.

@CCR_AACR: https://t.co/nDaiAT4c4D

[Rob Grant @ml4onc]

New research out today: ML can predict future symptoms during cancer treatment from EHR data. Congrats to Noke for his first paper during his PhD.👏 Great to collaborate with @PM_CDI and the rest of the team. @JCOCCI_ASCO @PMResearch_UHN. https://t.co/hRgqccA11x

[Grainne O'Kane @graokane]

PASS-01:ph II mFFX v GnP;#PDAC
denovo met ds; excl gBRCA/PALB2
➡️no clinically sig diff GnP v mFFX
➡️basal-like poor OS-mPFS on mFFX 3 mths
➡️54% receive 2nd line; mOS<6mths
➡️PDOs/ctDNA to come @AmberHabowski
1st-line biomarkers essential-RAS &🤞subtype
https://t.co/bZ1TCzTYiK

[Anirban Maitra @Aiims1742]

Terrific preprint by @hartjackson using imaging mass cytometry (IMC) & matched genomics for building multimodality prediction models:
Integrated spatial proteomics of human PDAC uncovers an expanded tumour–immune– stroma spectrum with genomic associations
https://t.co/zb4njVsBId

[Grainne O'Kane @graokane]

Final COMPASS trial data advanced #PDAC
➡️268 WGS& 253RNA-seq
➡️basal-like& hi GRIm-S ⬇️OS, both unique TME inc CD8 variation,NB primaries vs mets
➡️LTS :HRD, KRAS WT
➡️KRAS major enriches basal, >type II DM
➡️LAPC≠intact SMAD4
➡️47% receive 2nd line tx
https://t.co/wXcQY1kPvR

[JAMA Oncology @JAMAOnc]

Study demonstrated cisplatin treatment was followed by a predictable decrease in the estimated glomerular filtration rate (eGFR), placing patients with a lower baseline eGFR at the highest risk of CKD. https://t.co/paWMDkYMEV

[Rob Grant @ml4onc]

Sharing our research in @JAMAOnc predicting chronic kidney disease after cisplatin treatment. Thanks to @KevinJCHe, @onconeph, @MarzyehGhassemi, and the rest of the team, as well as @ICESOntario, @PMResearch_UHN, @thePMCF, and @OICR_news for their support

https://t.co/5zetfVUe48

[Rob Grant @ml4onc]

Congrats to PhD student Noke's team for winning the @UofT_TCAIREM Health Datathon! https://t.co/YABgTS25No

[Rob Grant @ml4onc]

Inspiring to see the international community come together at the PRECEDE Annual Meeting to figure out how to prevent pancreatic cancer! Our screening program at @pmcancercentre contributes to this important initiative

[Diane M. Simeone, MD @MadameSurgeon]

The @PrecedeStudy, the nation’s largest pancreatic cancer early detection initiative, is holding its annual meeting in San Diego on Nov 7-8. We aim to improve early detection and increase the 5-year survival rate to 50% in the next decade! https://t.co/3DQFkyj4lz

[Diane M. Simeone, MD @MadameSurgeon]

The @PrecedeStudy, the nation’s largest pancreatic cancer early detection initiative, is holding its annual meeting in San Diego on Nov 7-8. We aim to improve early detection and increase the 5-year survival rate to 50% in the next decade! https://t.co/3DQFkyj4lz

[Rob Grant @ml4onc]

Congrats to David, Kevin (co-supervised with @bhaibeka), and Yuanchang (with PanCuRx at @oicr_news and @LabNotta) ! And huge thank you to MOHCCN for the support!

[Marathon of Hope Cancer Centres Network @marathonofhope]

The winners are:

📸🔼 Julia Nguyen (UHN), Yuanchang Fang (UHN), Dr. David Henault (UHN), Xin Kevin Wang (UHN), Ali Khajegili Mirabadi (UBC), Xindi Zhang (OICR)

📸🔽Jorge Pinzón-Mejía (Dal), Hyojin Song (UCalgary), Caralyn Reisle (BC Cancer), Andrew Garvin (Queen's University)

[Rob Grant @ml4onc]

Thank you to TD Ready Commitment. We are honoured and appreciate the responsibility that comes with this incredible gift. Our team is already hard at work to realize our vision of using AI to improve cancer care.

[The Princess Margaret Cancer Foundation @thePMCF]

Thank you to TD Ready Commitment for their generous gift. You’re making it possible for Dr. Robert Grant and his team to improve cancer patients’ lives with AIM2REDUCE, an AI-based early warning system for patients who would be more likely to face adverse cancer events.

[Rob Grant @ml4onc]

Great summary of our recent study on the performance of LLMs on medical oncology exams in @JAMANetworkOpen.
Amazing effort from @IanHirsch3 and the team!
Thanks to @thePMCF @pmcancercentre @PM_CDI @OICR_news @ICESOntario

[Ian Hirsch @IanHirsch3]

1/
Large Language Models (LLMs) contain extensive medical knowledge despite not being specifically trained for it; but, their performance on standardized tests across various subspecialties is inconsistent.

[Grainne O'Kane @graokane]

PASS-01 trial #PDAC #ASCO24
➡️rand ph2 mFFX vs.GnP
➡️WGS/RNA/PDO/CTCs/ctDNA
✅PP PFS 5.5 (GnP) vs. 4.0mths (mFFX)
➡️PP ❌gBRCA/PALB2 >KRASWT in GnP
➡️MTB directed 2nd line
➡️ GnP remains a backbone for drug dvp
➡️basal-like unmet need
Proud @AmberHabowski as translational leads

[Arndt Vogel @ArndtVogel]

🌞Great sunny day in Toronto, just starting the Cholangiocarcinoma in PSC Symposium at @UHN
🤩Looking forward to great talks and discussion on new strategies for prevention and treatment of cancer in PSC
@myESMO @EASLedu @ILCAnews @curecc #livertwitter @sapisochin

[FACIT @FACITca]

REACT is an AI chatbot to help healthcare workers triage care for patients with cancer. Looking forward to Robert Grant @pmcancercentre @UHN_Research pitching his innovation at Falcons' Fortunes this Thursday. #FF2024
https://t.co/96lHDs5NKw

[Rob Grant @ml4onc]

🔥Great summary by @KevinJCHe of his study! 👏👏

[Kevin He @KevinJCHe]

1/
Palliative care (PC) can significantly improve outcomes for advanced cancer patients. But limited capacity often delays or prevents access. Our latest study from Ontario, 🇨🇦, explores using machine learning to address this gap. @JCO_ASCO https://t.co/QdUL99f5lo

[ICES @ICESOntario]

🎉 Welcome to the team Robert Grant! Dr. Grant's research focuses on using machine and deep learning to integrate multimodal data to improve clinical decision-making for people with cancer https://t.co/S1zCMxm8TC