This is a diagnostic immunohistochemistry app that I have been working on:
https://t.co/l2sqmLj6CR
It is very much a work in progress and comes with all the usual caveats: there are almost certainly omissions, errors, and oddities that need fixing.
Traditional serrated adenoma (TSA) and tubular adenoma (TA) in the same biopsy cup. The nuclei in the TSA are much smaller and paler than those in the TA, even in the proliferation zones (the ectopic crypt formations).
Chat with our residents & leaders, hear about life as a Buckeye, and learn what it’s like to train at one of the nation’s largest cancer centers & top 3 children’s hospitals.
We can’t wait to meet you!
#pathmatch26#GoBucks@OhioStatePath
🥷 GLI1 strikes again!
🧬 Check out this article describing GLI amplification in 85% Low grade OS 🦴
🆕 New fusion partner described
🔬 No morphologic overlap with GLI altered mesenchymal tumours in this study, but may be too soon to tell!
Read more to find out https://t.co/UzFEYwKKuG
Amazing - @WendyFrankelMD, Distinguished Professor Emeritus in Pathology at @OhioStateMed, received @TheUSCAP F.K. Mostofi Award Distinguished Service Award! This prestigious award is given annually to a member of the Academy in recognition of their outstanding service. Kudos!
Solitary liver lesion. No history
The IHC markers are SMA and HMB45
I know you're meant to call it PEComa (first three letters capitals, remainder not); but I decided to sign it out as PECOMA (all capitals)
That's the sort of rebellious thing you do when you're a pathologist!
Infarct necrosis important to separate from true tumour necrosis in NETs.2 show true necrosis(abrupt transition, karyorrhectic debris, comedo-like)& 2 show infarct(gradual transition, zonal granulation tissue/myobroblasts)
If you think easy -> retweet
If you think hard -> like
Dear @IARCWHO, I reviewed the Breast Tumors Committee. Only 1 out of 17 members (~6%) is from the Global South. Does IARC believe breast cancer predominantly occurs in developed countries?
The reality: most breast cancers occur in the Global South, with significantly worse outcomes than in the developed world. Remarkably, India—soon to be the world’s most populous country—has no representation across the Breast, Digestive, or GYN committees.
I can easily name dozens of brilliant Indian pathologists who could meaningfully contribute. Representation matters. Outcomes matter. We must do better. #GlobalHealth #Equity #PathTwitter
The Atlas of Medical Foreign Bodies (https://t.co/yMDuhSVAHW) continues to grow thanks to contributions by fellow tweeples. It now contains 555 images with descriptions and is searchable. If you haven't visited the site recently please have a look.
Papillary immature squamous metaplasia in anal transitional mucosa. It is essentially "AIN0.5"; it seems not to progress (although progression in AIN1/LSIL is rare) and is related low low-risk HPV. At low magnification it can mimic AIN2/HSIL. #UMiamiPath
PMID: 26551619.
Fascinating example of gallbladder with heterotopic pancreas. Dropped off on my desk by Prof. Young. Originally a consult to Prof. Scully. PS so glad to see tissue folds from the 1980s - some things never change! #GIpath
I am a huge proponent of educational webinars for learning 🧠 #PathWebinarPearls
👇👇👇is a compiled list of societies that regularly host educational webinars- many of which I have listened to myself! Most of these are FREE for residents, you may need to register as a member.
A tweetorial on p53 in Barrett's esophagus
P53 immunohistochemistry for the diagnosis of Barrett’s dysplasia.
There are believers…
And lots and lots of non-believers
(I was a non-believer, but I have reached the promised land)
What changed my mind?
Dr Zen:
Last WHO accepted 2 iCCA subtypes: small and large duct.
Supported by molecular studies.
IDH1 and FGFR fusions only seen in iCCA small duct type, while large duct resembles eCCA and pCCA.
Morphology correlates with genetics.
#USCAP2024