ms2lda

MS2LDA discovers substructure patterns in metabolomics data! Register on to try it out! #metabolomics #massspec #datamining

[ms2lda @ms2lda]

@AnaiaAdam Hello, we have/had some issues with the web service recently. Could you please try to login again and redo your analysis? If it keeps failing, could you contact us through the issues at GitHub? https://t.co/CFxJwF692z

[Lucy D’Agostino McGowan @LucyStats]

📣Our 🆕 paper Causal Inference is Not Just a Statistics Problem is out! @malco_barrett, @travisgerke, and I show that you can have 4 data sets with identical summary stats & visuals but very different data generating mechanisms-statistics alone can't tell you what to adjust for!

[ZiemertLab @ZiemertLab]

@NadineZiemert just delivered a talk at #cmfi2023 describing the work done in the @ZiemertLab ! Want to hear more? Check out the group's posters P35 & P99!

[ms2lda @ms2lda]

Following our earlier message, the job system was successfully restored! Please note that all jobs submitted since September 25 have failed, so you can remove them from your pending items and resubmit them (once!) - thanks for your patience! #substructure search #CompMetabolomics

[ms2lda @ms2lda]

As some of you may have noticed, the #MS2LDA was temporarily out of air due to a server migration. As a result, it looks like the job running system is not functioning as it should be. Hold on your submissions until we found the root cause of this.... #CompMetabolomics

[Robin Schmid @rschmid1789]

On my train ride to the DGMS Young Scientist meeting from Prague-Hünfeld. Thanks to @DgmsYngSct for the invite. I will present computational tools and their application to #MassSpectrometry #metabolomics. Based on work with many collaborators and friends...

[MetaboNews @MetaboNews]

The August issue of #MetaboNews is emailed to subscribers' inbox. #MetaboInterview with Dr. Justin van der Hooft
@jjjvanderhooft
Subscribe at: …https://t.co/uC4hqAcPP8…

@EMN_MetSoc
@TMIC_Canada
#metabolomics

[Justin van der Hooft @jjjvanderhooft]

It was nice to introduce @ms2lda to the participants of the summer school in Copenhagen! 😎 #CompMetabolomics After explaining the motivation and concept, I provided tips and advice on how to use MS2LDA. A recording will be available later!

[Justin van der Hooft @jjjvanderhooft]

Always a pleasure to return to CPH! 😎 Even the weather prepared itself well for the summer school! 🌞 Looking forward to a week full of #metabolomics #CompMetabolomics including @mzmine_project, @GNPS_UCSD, @ms2lda, #SIRIUS, #matchms, #MS2Query, and much more!

[The Cultural Tutor @culturaltutor]

We're so used to seeing and hearing about the pyramids that it's easy to forget how strange and extraordinary they really are.

So, just to remind you:

When woolly mammoths went extinct the Pyramids of Giza were already more than 500 years old.

Cleopatra and Julius Caesar are closer in time to the present day — to the Burj Khalifa — than to the construction of the Pyramids of Giza.

Where are they and who built them?

There are three pyramids on the Giza Plateau, which is on the west bank of the River Nile, in northern Egypt. They aren't far from Memphis, which was the capital of Ancient Egypt when they were constructed.

The largest and oldest was built in less than thirty years around 2570 BC for the Pharaoh Khufu. The second was built for Khufu's son, Khafre, and is only a few metres shorter. The third and smallest was then built for Menkaure, Khafre's son. Three monumental tombs for three generations of the same family.

Nearby are many more tombs for various members of the royal court, the Sphinx, several more temples, and the remains of a sort of workers' town including houses, workshops, bakeries, kitchens, breweries, a hospital, and a necropolis.

Khufu's Pyramid, known as the Great Pyramid, was the tallest building in the world for over 3,800 years — that is, until the spire of Lincoln Cathedral in England was constructed in 1311.

And at more than 6 million tonnes it was the heaviest manmade structure ever built, and is still third behind only the Great Wall of China and the Three Gorges Dam.

The mortar used in constructing the Great Pyramid alone weighs over half a million tons, which is more than the total weight of the Burj Khalifa.

See, the Great Pyramid is almost entirely solid — there are only a few narrow shafts and three small chambers inside. It was largely built from huge blocks of local Giza limestone, although its exterior was once covered in polished white limestone transported there from nearby Tura, and its interior includes blocks of granite weighing up to 80 tonnes transported from Aswan, over 500 miles away.

The *precision* of the pyramids is also remarkable. On a technical level their masonry is astonishingly accurate, but even more amazing is that the four sides of the Great Pyramid are all almost exactly the same length — they have a variation of no more than 60 millimetres.

Not to forget that all three pyramids are aligned according to the points of the compass — within one tenth of a degree of perfect geographical accuracy.

And if these facts weren't impressive enough, the actual construction of the pyramids — the specifics of how the blocks were quarried, transported, and lifted into place — remains a marvel we have yet to fully understand.

But those are merely the facts of the Pyramids of Giza; perhaps more interesting is what they really mean.

After all, you can learn a lot about any society from its architecture. What we say about ourselves can rarely be trusted — but what we do and what we leave behind is always truthful. In other words, that which we build expresses our priorities, how our society works, and who has the most power.

Think of it this way: what are the biggest buildings in the modern world?

By volume it is factories (the Boeing Everett Factory is number one right now) and distribution centres.

By total floor space it is airports and malls.

By height it is mixed-used skyscrapers, though they are usually dominated by offices, especially relating to finance. The Pentagon was the world's largest office building until this year; it has been overtaken by the Surat Diamond Bourse in India.

By capacity? Well, there are sports stadiums, the biggest of which is the Narendra Modi Stadium in India, with an official capacity of 132,000. That being said, no single complex can hold a greater number of people than the Masjid al-Haram in Mecca, which has a capacity of 4 million.

So the largest buildings in the 21st century are almost all related to industry, finance, retail, transport, and leisure — with religious worship something of an outlier. This is a technologically advanced, industrial, highly consumerist society in which businesses hold a great deal of power, and in which the wants and demands of the public are very important.

For comparison, during the Middle Ages nothing came remotely close to cathedrals in size or complexity, though castles and fortresses were also far bigger than everything else. We can draw the basic conclusion that religion was of immense and central importance, that the church as an institution was very wealthy, and that power was actually spread out among the hereditary nobility rather than being entirely concentrated in the monarch alone, not to mention the political and spiritual power also held by the church.

So, what about the Pyramids?

The Ancient Greek historian Herodotus remarked that the Pyramids of Giza were proof of how tyrannical a ruler Khufu — or Cheops, as the Greeks called him — must have been. In his native Greece the largest buildings were temples for public worship; the Great Pyramid was a monument to but one man alone, and this shocked Herodotus.

The biggest buildings of the 21st century are all useful. They have a clear and immediate purpose, and usually one which benefits — in some sense — lots of people. A factory produces things we all use, a distribution centre organises our online shopping, an office is a place of work, and a stadium is where we go for entertainment. Our largest buildings are intimately and inseparably related to employment and consumption.

What about the Pyramids? They were tombs for the Pharaohs and they were supposed to last forever. In other words, they had no immediate use or purpose, at least for the living. They served only one person: the Pharaoh — plus his family and closest supporters, though they were buried nearby rather than inside — in his journey through the Afterlife.

So this is not the same as a large and lavish royal or presidential palace; such buildings are designed to be used as a seat of power and administration — by several succeeding generations or leaders.

Meanwhile, all the resources and labour that went into building the Pyramids, which were literally manmade mountains, were for the benefit of one Pharaoh alone, after his life had ended — and, to a lesser extent, those lucky enough to have been buried nearby at the time.

Does that mean Khufu and his descendants were tyrants? In some sense, yes. But there is evidence that those who built the Pyramids were not, as Herodotus thought, slaves, and were instead closer to conscripted workers and freely employed craftsmen who were fairly remunerated for their labour.

See, it wasn't just that Khufu held total political power; he was also the spiritual leader of his subjects, such that their work was fundamentally religious in nature — it might have even helped them achieve a better afterlife.

There was nobody who could refuse Khufu's desire to build the largest tomb in human history, because he was a divinely appointed intermediary between gods and humans; no regulation to stop him, because his will was the law; no limits to his expenditure, because he collected the taxes and owned all the land in the kingdom.

However powerful the world's richest and most influential people might now seem, none of it compares to the power wielded by Pharaohs like Khufu; a power that was political, financial, legal, military, and spiritual — absolute.

And so the Pyramids are a glimpse into a society fundamentally and almost irreconcilably different from that in which we now live, to the earliest epochs of human civilisation, long before democracy and the rule of law, when one man could rule as a god and have mountains built to serve as his personal, eternal monument on earth.

[David Elser @DavidElser3]

I'm happy to share with you the pre-print of Mass2SMILES. Many thanks to @me_datapoint for guidance in computational questions and to my supervisor @e_gaquerel for giving me the freedom to explore my ideas.
https://t.co/y1IoV3D7uj

[Aaron Wiedemer (he/him) @aaron_wiedemer]

Learning @ms2lda today -

[Michael Witting @wittingmichael1]

New article alert: https://t.co/BfuG2LE8S5
Happy to present @liesasalzer latest article on CE-MS for #celegans #metabolomics published in @metabolomics! @ChemBioSys_muc @Schmitt_Kopplin #MetClassNet

[Madeleine Ernst @ernst_Madeleine]

There's still time to apply for our Summer School on Non-Targeted Metabolomics Data Mining for Biomedical Research @SSI_dk, 21-25 August 2023 in Copenhagen!
Don't miss it, deadline for sign-up is May 30th!
#computational #metabolomics #preprocessing #annotation #interpretation

[Helena Mannochio Russo @helenamrusso2]

I’m happy to share my most recent publication in Journal of Natural Products! In this work we describe nitropropanoyl glycosides from #Malpighiaceae with larvicidal activity https://t.co/AND6V4JBoT

[NimwegenLab @NimwegenLab]

Come join our lab! We're looking for a post-doc with a strong quantitative background and interest in the function and evolution of gene regulatory networks. The specific project is flexible and will be defined jointly with the candidate.
https://t.co/qlLybG80V2
Please RT.

[ms2lda @ms2lda]

@allijjackson That is a statement! You will not come back anytime soon I take it....

[Emma Schymanski @ESchymanski]

Latest PubChemLite (Jan 2023 edition) is out!
#OpenScience #exposome #cheminformatics

PubChemLite for Exposomics https://t.co/z5OOGPOgYx

[Nikiforos Alygizakis @nikiforosgr]

I believe that this is a huge step for bringing #NTS closer to regulation. A #machinelearning based identification point scoring system, which allows automation, reproducibility and transparency in confidence communication.

Link: https://t.co/NYUcBxQFme

#NTA #nontarget #masspec

[Florian Huber @me_datapoint]

Got an edited article back that I reviewed. And the 2nd reviewer only commented with "No changes required".

Feels like yet another sign of the academic system being in trouble. I learned that such answers usually mean "had no time, probably fine".

#academicchatter #publishing