A promising drug target for regenerating functional β-cell mass in diabetes!
@WorthamLab, @msanderlab & team @UCSanDiego discover the deacetylase SIRT2 restrains proliferation of pancreatic β-cells in a glucose-dependent manner: https://t.co/7pmUrXyfl7
The image shows labeling of SIRT2 (red), insulin (green), and nuclei staining (blue) in mouse pancreatic islet sections.
We are recruiting a postdoctoral researcher @MDC_Berlin
iPSC islet cell models
High throughput screens in iPSC models
Organ-on-a-chip
Genomics and computation
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https://t.co/CkXXSIWwEp
Join us for a talk by Maike Sander on "Understanding and Treating Diabetes with Islet Stem Cell Models" April 29, 2024 16:00, BioQuant, SR41
@UniHeidelberg@uniklinik_hd@msanderlab@MDC_Berlin
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On March 1, our Scientific Director Maike Sander (@msanderlab) will take up her appointment as professor for "Pancreatic Organoid Research and Disease Modeling" at @ChariteBerlin. Dean Joachim Spranger presented her with the certificate. Congratulations!
https://t.co/FkNh6664ic
Congratulations to @WorthamLab and the many other contributors. The study identifies Sirtuin-2 as a glucose-dependent regulator of beta cell proliferation.
I’m excited to share our discovery of a novel regulator of adaptive beta cell proliferation–the protein deacetylase SIRT2–from work in @msanderlab together with many key contributors including Bastian Ramms, Chun Zeng, Jackie Benthuysen, and @someshtweet https://t.co/0fCdwfOx6b
Thrilled to announce that registration and abstract submission for European Islet Study Group meeting in Helsinki, Finland, 18-20 June 2024 is NOW OPEN! https://t.co/kk5ealxGZS
🚨Early-bird registration is March 15th, limited seats available🚨
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@reNEW_Global I am deeply saddened. Palle has been my scientific companion for 30 years. Always generous and genuine. He integrated me into the NIH Beta Cell Bio Consortium when I was a junior prof in Germany. This grant was pivotal for me to return to US - I owe my career to him.
Very much look forward to my upcoming visit to @CRGenomica - to learn about the outstanding science and to visit our @EULIFE_news partner institution. Of course, also to experience beautiful Barcelona.
Out today @NatureGenet our work on mechanisms of beta cell dysfunctions in type 2 diabetes (T2D) combining single-cell genomics and Patch-seq. Congratulations to @GaoweiW@JoshChiou, Chun Zeng. Big thanks to @kjgaulton@seb11pr@bcellorg, F Kandeel, S Kim.
https://t.co/mFreaSVooE