LOCOMOTIVE ENGINEER
Saved by the Blood of Jesus Husband to @SmileysWife82 Full Patch @SOAMCSC 1-21 INF Army Veteran / Drill SGT Musician & Public Figure
Prayerfully consider supporting our Motorcycle Club, the Seed of Abraham MC obtain a 501C3 so we can perform the charitable giving and ministry we have been called to do.
The SOAMC is a Christian Motorcycle Club, our chapter being located in Columbia, SC. https://t.co/U2phHud47y
🚨🇸🇾 Esclavas sexuales a la venta en mercados locales de Siria. Keir Starmer y el rey Carlos recibieron recientemente en el Reino Unido al presidente sirio Ahmed al-Sharaa. Incluso dijeron que hay mucho que aprender de la cultura islámica.
A new shot literally regrows knee cartilage.
Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA).
The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration.
In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage.
This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes.
The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain.
Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation.
Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery.
[Agarwal, P., Su, S., Ancel, S., et al. (2025). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science. DOI: 10.1126/science.adx6649]
They made a new kind of weapon. And they’re testing it on us.
Buckle up for Adam Wingard’s super soldier slasher ONSLAUGHT, starring Adria Arjona, Alex Pereira, Dan Stevens, and more. In theaters Sept 4.
The Marine Corps is poised to say goodbye to one of its hallmark historic aircraft, the AV-8B Harrier II, the British-designed "jump jet" that became a key weapon in battlefronts across four decades.
https://t.co/BnPi4gcINt