MDMA plus high-dose psilocybin was the hardest psychological work Andrew Huberman has ever done.
He is explicit: no one should try this without clinical support, and many people should not take these compounds at all. He has only done the combination twice.
MDMA first created the empathogen effect that made difficult material approachable. Psilocybin alone at four to five grams of dried mushrooms had been terrifying and physically harsh.
Together, the MDMA allowed him to stay with the hardest childhood material instead of pushing it away. He also reported no typical post-MDMA drop.
Both compounds increase neuroplasticity in different ways, MDMA primarily through elevated serotonin and oxytocin systems, psilocybin through 5-HT2A receptor activation, which may explain why the sequence felt uniquely intense and why the usual comedown was absent.
Huberman has a rare ability to describe extreme personal experiences with precision, honesty, and strong caveats. That combination is what makes his accounts trustworthy.
falls jemand mal wieder ein aktuelles beispiel dafür benötigt warum so viele menschen mittlerweile einen scheiß auf irgendwelche "studien" geben https://t.co/lUPWs5BBhn
"wir labern zwar seit jahren davon dass us tech scheiße ist, aber wenn ihr bald euer alter im internet nachweisen wollt, dann müsst ihr android oder ios benutzen"
ich hab keine lust mehr mich von kernbehinderten bevormunden zu lassen https://t.co/jqNCgf7l7R
gut, es funktioniert so zu 90% wie ich es mir vorgestellt habe, aber hat mich umgerechnet 540 gigabyte vpn-traffic gekostet.. genug mit vibe-coding fürs erste
ich brauch tree-view diff ansicht für 2 registry snapshots
"probier das oder das"
probiere halbe stunde, beides ist komplette affenscheiße und halluziniert
"ja oh sorry die beiden tools können das doch nicht"
WILLST DU MICH VERARSCHEN DU GOTTVERFICKTER CLANKER HURENSOHN?????
mein vpn anbieter hat aus irgendwelchen gründen auch ein OpenWebUI mit paar LLMs und das GLM-5.2 dort hat mir das jetzt einfach first-try gescriptet anstatt die selbe scheiße wie grok und gemini zu halluzinieren. bin baff
Twitch and Amazon are apparently planning to use streams to train Generative AI.
Multiple sources tell me it will be announced in the coming months, despite some internal friction against it. Creators may be able to opt out of some training data.
dhl bote scannt vor mir mein paket, es erscheint "Paket vor dem Eingang ablegen" auf seinem display. er erzählt mir danach, dass das falsch ist und so nicht stimmt?????
ich hab so kein bock mehr in jedem bereich meines alltags mit gestig behinderten mongokindern reden zu müssen
NEW - Europol releases a EU Terrorism Situation and Trend Report showing that left wing terrorism completed 11 attacks out of 12, jihadism 9 out of 24 - with these attacks accounting for the majority of injuries, and there was 1 right wing attack completed out of 5.
hab seit ner stunde feierabend aber kann nicht gehen weil der rechner den ich fertigmachen muss seit stunden kumulative windows updates installiert. fick mein leben
jeden tag so viele lustige edits die ich nicht reposten kann, weil hier selbst bei katzenvideos irgenwelche swastikas und sonnenräder reineditiert sind.
das leben als brd-cuck ist großartig!
It's happening: Windows 11 is getting a modern Properties sheet, replacing decades-old legacy code.
File Explorer’s classic Properties window, which still traces back to the Windows 95-era property sheet system, is now being rebuilt with WinUI 3.
And yes, it supports dark mode.
This is not a cheap WebView2 shell either. The new Properties dialog appears to be native WinUI, with modern tabs, accent indicators, rounded checkboxes, and updated controls.
The current Properties dialog is ancient. It still comes from the old Win32 Common Controls world, and while it has been visually touched up over the years, the underlying system has barely changed.
But this is also why Windows modernization is hard.
Third-party apps like 7-Zip, Dropbox, antivirus tools, and codec packs can inject their own tabs into the Properties dialog using legacy shell extensions.
Microsoft cannot just replace the old host without preserving those integrations. Microsoft is now modernizing a 30-year-old Windows surface without breaking decades of apps.
Windows is so back!
hab grad 180€ für ne füllung gelatzt während ich seit 1-2 jahren regelmäßig solche meldungen sehe.
entweder ist das alles bullshit oder die zahnarzt lobby ist mächtiger als gedacht
Researchers at the University of Nottingham in the UK have developed a groundbreaking protein-based gel that leverages calcium and phosphate ions, naturally abundant in human saliva, to repair and regenerate damaged tooth enamel.
This innovation, detailed in a study published in Nature Communications, represents a potential shift away from traditional "drill and fill" dentistry toward true enamel restoration.
The gel mimics the natural proteins that guide enamel formation during infancy. When applied to teeth, it forms a thin, robust layer that seeps into cracks and eroded areas.
Acting as a scaffold, it attracts and organizes calcium and phosphate from saliva (or even donated saliva samples), promoting "epitaxial mineralization"—a process where new enamel crystals grow in perfect alignment with the existing tooth structure, restoring its hardness and architecture.
Lab tests showed the regenerated enamel withstands real-world stresses like brushing, chewing, and acidic exposure (e.g., soda) as well as—or better than—natural enamel. It remained intact for weeks in simulated oral environments.
[Hasan, A. et al. Biomimetic supramolecular protein matrix restores structure and properties of human dental enamel. Nat Commun 16, 9434 (2025). DOI: 10.1038/s41467-025-64982-y]