Museer A. Lone

sphingolipids, rare diseases, breaking lipid pathways

[Cells MDPI @Cells_MDPI]

🔬 𝙉𝙚𝙬 𝙋𝙖𝙥𝙚𝙧 𝙋𝙪𝙗𝙡𝙞𝙨𝙝𝙚𝙙 𝙞𝙣 𝘾𝙚𝙡𝙡𝙨 𝙅𝙤𝙪𝙧𝙣𝙖𝙡

🎯 Intersection of Sphingolipid and Sterol Metabolism at the Level of Orm Proteins in Yeast

👥 Corresponding Author:
🧑Museer A. Lone (@MuseerSphinx)

🔗 Read the Full Article:
https://t.co/47QSaEGwow

[Museer A. Lone @MuseerSphinx]

Yeast Orm1/2 proteins regulate sterol levels. A new twist to membrane homeostasis and lipid regulation #cholesterol#sphingolipids

[Cells MDPI @Cells_MDPI]

🔬 𝙉𝙚𝙬 𝙋𝙖𝙥𝙚𝙧 𝙋𝙪𝙗𝙡𝙞𝙨𝙝𝙚𝙙 𝙞𝙣 𝘾𝙚𝙡𝙡𝙨 𝙅𝙤𝙪𝙧𝙣𝙖𝙡

🎯 Intersection of Sphingolipid and Sterol Metabolism at the Level of Orm Proteins in Yeast

👥 Corresponding Author:
🧑Museer A. Lone (@MuseerSphinx)

🔗 Read the Full Article:
https://t.co/47QSaEGwow

[Museer A. Lone @MuseerSphinx]

Pre-print alert! we try to understand how mutations in Serine-plamitoyltransferase (SPT) subunits shape sphingolipid metabolism in #sensoryneuropathy #ALS n #sensorymotor neuropathy.
Sphingolipid remodelling in SPT-related neuropathies https://t.co/dSpyMe7KSx

[Scott Summers @ScottSummers339]

Excited to share my invited JLR Lectureship article — a big-picture, and somewhat provocative, take on why evolution chose sphingolipids…and the costs that choice carries. https://t.co/LFPK5ir4fz

[Museer A. Lone @MuseerSphinx]

Fully funded PhD (3y)
I’m recruiting a PhD student in lipid metabolism & ALS at University Hospital Zurich/ University of Zurich.
Lipidomics • MS • neurons
🇨🇭/🇪🇺 only · immediate start
DM for details. @SL_Biology @Lipids_IdISBa @lipidmaps

[Museer A. Lone @MuseerSphinx]

@DrAltafAhmad Thanks Dr Altaf

[Museer A. Lone @MuseerSphinx]

Impact factors rarely capture groundbreaking work. In a study led by X-less Michele Visentin and myself, we identify acylome switching as early marker of chronic kidney disease with HFD.
Check it out! #KidneyResearch #Metabolism #Lipidomics

https://t.co/Lz7YUqeBoZ

[Museer A. Lone @MuseerSphinx]

@_PAHS_ Thank you Haseeb

[Andreas Hülsmeier @ahulsmeier]

Glycosphingolipids in neurodegeneration? 🧠 Lipids may hold the key to understanding Alzheimer's, Parkinson's, and beyond. Discover how glycosphingolipids influence neurodegeneration and explore their potential as therapeutic targets in this latest review.
https://t.co/0umP6Hc3kd

[Unispital_USZ @Unispital_USZ]

In einer Studie im @NatureMedicine zeigen Forschende von @ETH, @UZH_ch, @UniSpitalBasel und KSBL einen neuen, vielversprechenden Ansatz: Digoxin löst Klümpchen von zirkulierenden Krebszellen im Blut auf und reduziert so die Gefahr von Metastasenbildung.

https://t.co/yAEDMzhGm2

[Museer A. Lone @MuseerSphinx]

@TehsildarCharar @BiotechFida @OfficeOfLGJandK @DC_Budgam @akshaylabroo @ECISVEEP Glad to see the amazing work you are doing

[ALS News Today @alsnewstoday]

The therapy’s developer is now planning a new Phase 3b trial that it hopes will pave the way toward approval. It’s expected to enroll about 200 people with ALS. Learn more: https://t.co/aKVNY2GRQE

#AmyotrophicLateralSclerosis #ALSDisease #ALSTreatment #ALSResearch #ClinicalTrial

[Luciano Abriata @labriataphd]

What is happening? HandMol is happening!
Coming soon, multiuser, immersive, interactive simulations.

[Fabio Cortes @fabiojcortes]

Molecular dynamics simulations in mixed reality!

With @labriataphd and @lucien_krapp we’re scaling our multi-user WebXR platform to enable immersive molecular simulations, fully based on web technologies.

Stay tuned, lots of cool stuff coming soon!

@threejs #WebXR #Quest3

[Daniel J Drucker @DanielJDrucker]

Age related impairments in muscle function arise due to a reduction in CERS1, thereby underlining the importance of the sphingolipid biosynthesis pathway in age-related muscle homeostasis https://t.co/WAaDMLgt82

[Museer A. Lone @MuseerSphinx]

Prof. Lavade, absolutely a pioneer in the field!

[VanniLab @LabVanni]

Happy to share that our #lipidtime work on the conformational dynamics of lipid transport proteins by @sriraksha616 @AndreaDiLuca7 @dani_alv4 and @ATJohnPeter is now out in @PLOSBiology! Big thanks to collaborators @Gio_Dangel0 @GehinCharlotte @MuseerSphinx for the support!

[Museer A. Lone @MuseerSphinx]

@DrAltafAhmad @shaha_kash @KhalifaUni Thanks dear dr. Altaf

[Museer A. Lone @MuseerSphinx]

Thank you @shaha_kash and @KhalifaUni UAE for the invitation. We had a great conference.

[Shab Hassan @shaha_kash]

Dr @MuseerSphinx delivering a Keynote on “Decoding the sphingolipid enigma: bridging neurodegeneration, metabolism, and therapeutic frontiers” at the 3rd UAE Anatomy & Cellular Biology Conference #acbc held at @KhalifaUni

[Journal of Neurology, Neurosurgery and Psychiatry @JNNP_BMJ]

Authors of this study show that recurrent de novo SPTLC2 variant causes childhood-onset amyotrophic lateral sclerosis (ALS) by excess sphingolipid synthesis
https://t.co/Ki0sNIMGl8
@MuseerSphinx